Sample overview

Project Name	TCGA-UCEC
GSE ID	GSE212217
GSM ID	GSM6514140
Cell Line	None
Tissue type	Peripheral blood
Disease Type	MMRd Endometrial Adenocarcinoma
PMID	36301137
Initial gene number	36601
Initial cell number	10676
Post-QC gene number	6809
Post-QC cell number	400

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
HSC(Nos)_source	TGFB1_ligand	CD4+,T-cells(Nos)_target	TGFbR1_R2_receptor	2.628e-04	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
NK,cells(Nos)_source	TGFB1_ligand	CD4+,T-cells(Nos)_target	TGFbR1_R2_receptor	2.110e-04	0.02	TGFb	Secreted Signaling	KEGG: hsa04350
CD4+,T-cells(Nos)_source	TGFB1_ligand	HSC(Nos)_target	TGFbR1_R2_receptor	5.831e-05	0.04	TGFb	Secreted Signaling	KEGG: hsa04350
HSC(Nos)_source	TGFB1_ligand	HSC(Nos)_target	TGFbR1_R2_receptor	2.853e-05	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
NK,cells(Nos)_source	TGFB1_ligand	HSC(Nos)_target	TGFbR1_R2_receptor	2.308e-05	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
HSC(Nos)_source	TGFB1_ligand	NK,cells(Nos)_target	TGFbR1_R2_receptor	5.917e-05	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
NK,cells(Nos)_source	TGFB1_ligand	NK,cells(Nos)_target	TGFbR1_R2_receptor	4.753e-05	0.03	TGFb	Secreted Signaling	KEGG: hsa04350
CD4+,T-cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CD44_receptor	6.318e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
NK,cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CD44_receptor	1.233e-03	0.02	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD4+,T-cells(Nos)_source	TNFSF10_ligand	CD4+,T-cells(Nos)_target	TNFRSF10A_receptor	1.631e-04	0.0	TRAIL	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	CD40LG_ligand	CD4+,T-cells(Nos)_target	ITGA5_ITGB1_receptor	4.434e-04	0.0	CD40	Secreted Signaling	PMID: 28676852
CD4+,T-cells(Nos)_source	CD40LG_ligand	HSC(Nos)_target	ITGA5_ITGB1_receptor	4.886e-05	0.0	CD40	Secreted Signaling	PMID: 28676852
CD4+,T-cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGA5_ITGB1_receptor	1.156e-04	0.0	CD40	Secreted Signaling	PMID: 28676852
CD4+,T-cells(Nos)_source	CD40LG_ligand	CD4+,T-cells(Nos)_target	ITGAM_ITGB2_receptor	5.025e-06	0.0	CD40	Secreted Signaling	PMID: 28676852
CD4+,T-cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGAM_ITGB2_receptor	3.369e-04	0.0	CD40	Secreted Signaling	PMID: 28676852
NK,cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGAM_ITGB2_receptor	8.794e-07	0.0	CD40	Secreted Signaling	PMID: 28676852
NK,cells(Nos)_source	GZMA_ligand	CD4+,T-cells(Nos)_target	F2R_receptor	1.797e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
NK,cells(Nos)_source	GZMA_ligand	HSC(Nos)_target	F2R_receptor	2.877e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
NK,cells(Nos)_source	GZMA_ligand	NK,cells(Nos)_target	F2R_receptor	6.242e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
HSC(Nos)_source	APP_ligand	CD4+,T-cells(Nos)_target	CD74_receptor	1.680e-04	0.04	APP	Cell-Cell Contact	PMID: 19849849
CD4+,T-cells(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	7.790e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
HSC(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	9.142e-05	0.01	APP	Cell-Cell Contact	PMID: 19849849
NK,cells(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	3.019e-05	0.01	APP	Cell-Cell Contact	PMID: 19849849
CD4+,T-cells(Nos)_source	CD48_ligand	CD4+,T-cells(Nos)_target	CD244_receptor	1.366e-05	0.0	CD48	Cell-Cell Contact	PMID: 26697006
CD4+,T-cells(Nos)_source	CD48_ligand	NK,cells(Nos)_target	CD244_receptor	2.241e-03	0.0	CD48	Cell-Cell Contact	PMID: 26697006
NK,cells(Nos)_source	CD48_ligand	NK,cells(Nos)_target	CD244_receptor	3.394e-04	0.0	CD48	Cell-Cell Contact	PMID: 26697006
HSC(Nos)_source	CD99_ligand	CD4+,T-cells(Nos)_target	CD99_receptor	3.907e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	CD4+,T-cells(Nos)_target	CD99_receptor	1.423e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	3.907e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	4.117e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	1.523e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	1.423e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	1.523e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	5.615e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CLEC2D_ligand	NK,cells(Nos)_target	KLRB1_receptor	6.296e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	CLEC2D_ligand	NK,cells(Nos)_target	KLRB1_receptor	2.537e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD4+,T-cells(Nos)_source	CLEC2B_ligand	NK,cells(Nos)_target	KLRB1_receptor	3.866e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	CLEC2B_ligand	NK,cells(Nos)_target	KLRB1_receptor	3.747e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD4+,T-cells(Nos)_source	CD69_ligand	NK,cells(Nos)_target	KLRB1_receptor	4.689e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	CD69_ligand	NK,cells(Nos)_target	KLRB1_receptor	8.638e-04	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD4+,T-cells(Nos)_source	ITGB2_ligand	HSC(Nos)_target	CD226_receptor	6.087e-04	0.01	ITGB2	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	ITGB2_ligand	HSC(Nos)_target	CD226_receptor	2.908e-04	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	LCK_ligand	NK,cells(Nos)_target	CD8 receptor_receptor	4.550e-03	0.0	LCK	Cell-Cell Contact	PMID: 25427562
HSC(Nos)_source	LCK_ligand	NK,cells(Nos)_target	CD8 receptor_receptor	7.814e-08	0.0	LCK	Cell-Cell Contact	PMID: 25427562
NK,cells(Nos)_source	LCK_ligand	NK,cells(Nos)_target	CD8 receptor_receptor	1.196e-03	0.0	LCK	Cell-Cell Contact	PMID: 25427562
HSC(Nos)_source	HLA-A_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	6.754e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	2.599e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	HSC(Nos)_target	CD8A_receptor	1.706e-04	0.04	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8A_receptor	1.137e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8A_receptor	7.667e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8A_receptor	2.966e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-B_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	6.590e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	2.584e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8A_receptor	1.168e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8A_receptor	7.499e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8A_receptor	2.950e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-C_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	5.666e-04	0.04	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	2.444e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	1.077e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	6.535e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	2.804e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-E_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	1.119e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	3.181e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-E_ligand	HSC(Nos)_target	CD8A_receptor	7.319e-05	0.02	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8A_receptor	1.485e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8A_receptor	1.194e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8A_receptor	3.556e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-F_ligand	CD4+,T-cells(Nos)_target	CD8A_receptor	1.736e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-F_ligand	HSC(Nos)_target	CD8A_receptor	1.142e-04	0.02	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8A_receptor	6.195e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8A_receptor	2.044e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	1.558e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	1.040e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	4.033e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8B_receptor	1.599e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8B_receptor	1.018e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8B_receptor	4.013e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	1.479e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	8.929e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	3.823e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	2.012e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	1.578e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	4.792e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8B_receptor	8.640e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8B_receptor	6.973e-05	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8B_receptor	2.820e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRK1_receptor	1.469e-02	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
HSC(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRK1_receptor	1.182e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRK1_receptor	3.519e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-DPA1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.768e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DPA1_ligand	NK,cells(Nos)_target	CD4_receptor	4.863e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-DPB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	2.390e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DPB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.686e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	HLA-DPB1_ligand	NK,cells(Nos)_target	CD4_receptor	6.585e-05	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DPB1_ligand	NK,cells(Nos)_target	CD4_receptor	4.636e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DQA1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	9.965e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DQA1_ligand	NK,cells(Nos)_target	CD4_receptor	2.745e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DQA2_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	4.712e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DQA2_ligand	HSC(Nos)_target	CD4_receptor	9.420e-07	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DQA2_ligand	NK,cells(Nos)_target	CD4_receptor	1.300e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DQB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.455e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DQB1_ligand	NK,cells(Nos)_target	CD4_receptor	4.004e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DRA_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	6.291e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DRA_ligand	NK,cells(Nos)_target	CD4_receptor	1.734e-04	0.01	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DRB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.112e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DRB1_ligand	NK,cells(Nos)_target	CD4_receptor	3.063e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DRB5_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.635e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-DRB5_ligand	NK,cells(Nos)_target	CD4_receptor	4.497e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	PECAM1_ligand	HSC(Nos)_target	PECAM1_receptor	8.599e-06	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	PECAM1_ligand	NK,cells(Nos)_target	PECAM1_receptor	8.599e-06	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	PECAM1_ligand	NK,cells(Nos)_target	PECAM1_receptor	2.366e-05	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514