Sample overview
| Project Name |
TCGA-UCEC
|
| GSE ID |
GSE212217
|
| GSM ID |
GSM6514137
|
| Cell Line |
None
|
| Tissue type |
Peripheral blood
|
| Disease Type |
MMRd Endometrial Adenocarcinoma
|
| PMID |
36301137
|
| Initial gene number |
36601
|
| Initial cell number |
11582
|
| Post-QC gene number |
7305
|
| Post-QC cell number |
107
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| NK,cells(Nos)_source |
MIF_ligand |
CD4+,T-cells(Nos)_target |
CD74_CXCR4_receptor |
2.818e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source |
MIF_ligand |
NK,cells(Nos)_target |
CD74_CXCR4_receptor |
3.886e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source |
MIF_ligand |
NK,cells(Nos)_target |
CD74_CXCR4_receptor |
6.437e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source |
MIF_ligand |
CD4+,T-cells(Nos)_target |
CD74_CD44_receptor |
1.662e-03 |
0.04 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source |
MIF_ligand |
CD4+,T-cells(Nos)_target |
CD74_CD44_receptor |
2.757e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source |
MIF_ligand |
NK,cells(Nos)_target |
CD74_CD44_receptor |
2.016e-03 |
0.03 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source |
MIF_ligand |
NK,cells(Nos)_target |
CD74_CD44_receptor |
3.346e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source |
GZMA_ligand |
HSC(Nos)_target |
F2R_receptor |
3.035e-03 |
0.0 |
PARs |
Secreted Signaling |
KEGG: hsa04080 |
| NK,cells(Nos)_source |
GZMA_ligand |
NK,cells(Nos)_target |
F2R_receptor |
2.365e-06 |
0.02 |
PARs |
Secreted Signaling |
KEGG: hsa04080 |
| CD4+,T-cells(Nos)_source |
FLT3LG_ligand |
CD4+,T-cells(Nos)_target |
FLT3_receptor |
2.319e-04 |
0.01 |
FLT3 |
Secreted Signaling |
PMID: 25992210 |
| HSC(Nos)_source |
THBS1_ligand |
HSC(Nos)_target |
CD36_receptor |
1.828e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| NK,cells(Nos)_source |
THBS1_ligand |
HSC(Nos)_target |
CD36_receptor |
3.460e-06 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| HSC(Nos)_source |
APP_ligand |
CD4+,T-cells(Nos)_target |
CD74_receptor |
7.110e-04 |
0.01 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| HSC(Nos)_source |
APP_ligand |
NK,cells(Nos)_target |
CD74_receptor |
1.923e-03 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| CD4+,T-cells(Nos)_source |
CD48_ligand |
CD4+,T-cells(Nos)_target |
CD244_receptor |
1.031e-06 |
0.03 |
CD48 |
Cell-Cell Contact |
PMID: 26697006 |
| CD4+,T-cells(Nos)_source |
CD48_ligand |
NK,cells(Nos)_target |
CD244_receptor |
1.868e-06 |
0.0 |
CD48 |
Cell-Cell Contact |
PMID: 26697006 |
| NK,cells(Nos)_source |
CD48_ligand |
NK,cells(Nos)_target |
CD244_receptor |
2.284e-06 |
0.0 |
CD48 |
Cell-Cell Contact |
PMID: 26697006 |
| NK,cells(Nos)_source |
CD86_ligand |
CD4+,T-cells(Nos)_target |
CD28_receptor |
1.204e-08 |
0.03 |
CD86 |
Cell-Cell Contact |
PMID: 23954143 |
| CD4+,T-cells(Nos)_source |
CD86_ligand |
NK,cells(Nos)_target |
CD28_receptor |
1.319e-08 |
0.0 |
CD86 |
Cell-Cell Contact |
PMID: 23954143 |
| NK,cells(Nos)_source |
CD86_ligand |
NK,cells(Nos)_target |
CD28_receptor |
2.239e-08 |
0.0 |
CD86 |
Cell-Cell Contact |
PMID: 23954143 |
| HSC(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
6.346e-03 |
0.02 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
1.132e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
CD99_ligand |
NK,cells(Nos)_target |
CD99_receptor |
1.132e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
CLEC2B_ligand |
CD4+,T-cells(Nos)_target |
KLRB1_receptor |
2.312e-03 |
0.0 |
CLEC |
Cell-Cell Contact |
PMID: 24223577 |
| CD4+,T-cells(Nos)_source |
CD69_ligand |
CD4+,T-cells(Nos)_target |
KLRB1_receptor |
1.287e-03 |
0.0 |
CLEC |
Cell-Cell Contact |
PMID: 24223577 |
| NK,cells(Nos)_source |
CD69_ligand |
CD4+,T-cells(Nos)_target |
KLRB1_receptor |
7.538e-04 |
0.02 |
CLEC |
Cell-Cell Contact |
PMID: 24223577 |
| HSC(Nos)_source |
ICAM2_ligand |
CD4+,T-cells(Nos)_target |
ITGAL_ITGB2_receptor |
4.239e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
ICAM2_ligand |
NK,cells(Nos)_target |
ITGAL_ITGB2_receptor |
7.268e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
NK,cells(Nos)_target |
ITGAL_ITGB2_receptor |
1.335e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
CD4+,T-cells(Nos)_target |
ITGAM_ITGB2_receptor |
1.815e-06 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
ICAM2_ligand |
NK,cells(Nos)_target |
ITGAM_ITGB2_receptor |
2.240e-06 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
NK,cells(Nos)_target |
ITGAM_ITGB2_receptor |
4.153e-06 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
CD226_receptor |
6.566e-04 |
0.02 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
CD226_receptor |
2.042e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ITGB2_ligand |
CD4+,T-cells(Nos)_target |
ICAM2_receptor |
1.772e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
ICAM2_receptor |
1.041e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
ICAM2_receptor |
3.213e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
LCK_ligand |
NK,cells(Nos)_target |
CD8 receptor_receptor |
2.286e-03 |
0.0 |
LCK |
Cell-Cell Contact |
PMID: 25427562 |
| NK,cells(Nos)_source |
LCK_ligand |
NK,cells(Nos)_target |
CD8 receptor_receptor |
5.102e-03 |
0.0 |
LCK |
Cell-Cell Contact |
PMID: 25427562 |
| CD4+,T-cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
8.040e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
6.512e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.358e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
8.746e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
7.242e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.453e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
8.342e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
6.812e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.390e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.023e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.126e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.748e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-F_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
3.772e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-F_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.191e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
9.856e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
7.966e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.661e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.071e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
8.841e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.775e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.022e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
8.326e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.700e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.248e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.360e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
2.128e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-F_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
4.662e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-F_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.460e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRC1_receptor |
4.976e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 24223577 |
| HSC(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRC1_receptor |
5.622e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 24223577 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRC1_receptor |
8.568e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 24223577 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRK1_receptor |
1.076e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| HSC(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRK1_receptor |
1.182e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRK1_receptor |
1.839e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD94:NKG2A_receptor |
6.923e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| HSC(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD94:NKG2A_receptor |
7.746e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD94:NKG2A_receptor |
1.189e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| NK,cells(Nos)_source |
HLA-DPA1_ligand |
NK,cells(Nos)_target |
CD4_receptor |
1.874e-03 |
0.03 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-DPB1_ligand |
NK,cells(Nos)_target |
CD4_receptor |
1.851e-03 |
0.03 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
SELPLG_ligand |
CD4+,T-cells(Nos)_target |
SELL_receptor |
6.285e-04 |
0.01 |
SELPLG |
Cell-Cell Contact |
PMC2431087; PMID: 8892633,PMID: 8896607 |
| NK,cells(Nos)_source |
SELPLG_ligand |
CD4+,T-cells(Nos)_target |
SELL_receptor |
1.228e-03 |
0.0 |
SELPLG |
Cell-Cell Contact |
PMC2431087; PMID: 8892633,PMID: 8896607 |