Sample overview
| Project Name |
TCGA-UCEC
|
| GSE ID |
GSE212217
|
| GSM ID |
GSM6514136
|
| Cell Line |
None
|
| Tissue type |
Peripheral blood
|
| Disease Type |
MMRd Endometrial Adenocarcinoma
|
| PMID |
36301137
|
| Initial gene number |
36601
|
| Initial cell number |
12440
|
| Post-QC gene number |
7146
|
| Post-QC cell number |
117
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| Erythrocytes(Nos)_source |
TGFB1_ligand |
Erythrocytes(Nos)_target |
TGFbR1_R2_receptor |
2.578e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Erythrocytes(Nos)_source |
TGFB1_ligand |
NK,cells(Nos)_target |
TGFbR1_R2_receptor |
4.653e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| CD4+,T-cells(Nos)_source |
MIF_ligand |
NK,cells(Nos)_target |
CD74_CXCR4_receptor |
4.614e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source |
MIF_ligand |
CD4+,T-cells(Nos)_target |
CD74_CD44_receptor |
1.660e-03 |
0.03 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source |
MIF_ligand |
NK,cells(Nos)_target |
CD74_CD44_receptor |
3.722e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source |
IL16_ligand |
NK,cells(Nos)_target |
CD4_receptor |
8.359e-04 |
0.0 |
IL16 |
Secreted Signaling |
KEGG: hsa04060 |
| CD4+,T-cells(Nos)_source |
CD40LG_ligand |
Erythrocytes(Nos)_target |
ITGA5_ITGB1_receptor |
8.164e-07 |
0.02 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| CD4+,T-cells(Nos)_source |
CD40LG_ligand |
NK,cells(Nos)_target |
ITGAM_ITGB2_receptor |
1.576e-08 |
0.0 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| NK,cells(Nos)_source |
CD40LG_ligand |
NK,cells(Nos)_target |
ITGAM_ITGB2_receptor |
1.660e-08 |
0.02 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| CD4+,T-cells(Nos)_source |
THBS1_ligand |
Erythrocytes(Nos)_target |
CD36_receptor |
8.993e-07 |
0.02 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Erythrocytes(Nos)_source |
THBS1_ligand |
Erythrocytes(Nos)_target |
CD36_receptor |
2.024e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| NK,cells(Nos)_source |
THBS1_ligand |
Erythrocytes(Nos)_target |
CD36_receptor |
1.728e-06 |
0.02 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Erythrocytes(Nos)_source |
THBS1_ligand |
CD4+,T-cells(Nos)_target |
CD47_receptor |
1.198e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Erythrocytes(Nos)_source |
THBS1_ligand |
Erythrocytes(Nos)_target |
CD47_receptor |
2.905e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| NK,cells(Nos)_source |
THBS1_ligand |
Erythrocytes(Nos)_target |
CD47_receptor |
2.492e-06 |
0.04 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Erythrocytes(Nos)_source |
THBS1_ligand |
NK,cells(Nos)_target |
CD47_receptor |
7.102e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Erythrocytes(Nos)_source |
APP_ligand |
CD4+,T-cells(Nos)_target |
CD74_receptor |
6.540e-04 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Erythrocytes(Nos)_source |
APP_ligand |
Erythrocytes(Nos)_target |
CD74_receptor |
1.209e-04 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Erythrocytes(Nos)_source |
APP_ligand |
NK,cells(Nos)_target |
CD74_receptor |
1.839e-03 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| NK,cells(Nos)_source |
CD48_ligand |
NK,cells(Nos)_target |
CD244_receptor |
2.548e-06 |
0.02 |
CD48 |
Cell-Cell Contact |
PMID: 26697006 |
| Erythrocytes(Nos)_source |
CD99_ligand |
Erythrocytes(Nos)_target |
CD99_receptor |
4.451e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
CD99_ligand |
Erythrocytes(Nos)_target |
CD99_receptor |
1.302e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
CD99_ligand |
NK,cells(Nos)_target |
CD99_receptor |
1.302e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
CD99_ligand |
NK,cells(Nos)_target |
CD99_receptor |
3.736e-02 |
0.03 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
CLEC2D_ligand |
NK,cells(Nos)_target |
KLRB1_receptor |
1.829e-03 |
0.0 |
CLEC |
Cell-Cell Contact |
PMID: 24223577 |
| NK,cells(Nos)_source |
CLEC2B_ligand |
NK,cells(Nos)_target |
KLRB1_receptor |
7.275e-03 |
0.0 |
CLEC |
Cell-Cell Contact |
PMID: 24223577 |
| NK,cells(Nos)_source |
CD69_ligand |
NK,cells(Nos)_target |
KLRB1_receptor |
7.303e-03 |
0.0 |
CLEC |
Cell-Cell Contact |
PMID: 24223577 |
| NK,cells(Nos)_source |
ICAM1_ligand |
NK,cells(Nos)_target |
ITGAX_ITGB2_receptor |
2.056e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 16252253 |
| NK,cells(Nos)_source |
ICAM1_ligand |
NK,cells(Nos)_target |
ITGAL_ITGB2_receptor |
1.689e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
ICAM2_ligand |
CD4+,T-cells(Nos)_target |
ITGAL_ITGB2_receptor |
2.733e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
ICAM2_ligand |
NK,cells(Nos)_target |
ITGAL_ITGB2_receptor |
1.053e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ICAM1_ligand |
NK,cells(Nos)_target |
ITGAM_ITGB2_receptor |
4.616e-06 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
ICAM2_ligand |
CD4+,T-cells(Nos)_target |
ITGAM_ITGB2_receptor |
8.635e-07 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
ICAM2_ligand |
NK,cells(Nos)_target |
ITGAM_ITGB2_receptor |
2.904e-06 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ICAM1_ligand |
CD4+,T-cells(Nos)_target |
ITGAL_receptor |
3.020e-04 |
0.04 |
ICAM |
Cell-Cell Contact |
PMID: 23602662 |
| NK,cells(Nos)_source |
ICAM1_ligand |
NK,cells(Nos)_target |
ITGAL_receptor |
8.060e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 23602662 |
| NK,cells(Nos)_source |
ITGB2_ligand |
Erythrocytes(Nos)_target |
CD226_receptor |
2.092e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ITGB2_ligand |
NK,cells(Nos)_target |
ICAM1_receptor |
3.526e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
ITGB2_ligand |
Erythrocytes(Nos)_target |
ICAM2_receptor |
3.938e-04 |
0.01 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ITGB2_ligand |
Erythrocytes(Nos)_target |
ICAM2_receptor |
2.179e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
LCK_ligand |
NK,cells(Nos)_target |
CD8 receptor_receptor |
1.885e-03 |
0.04 |
LCK |
Cell-Cell Contact |
PMID: 25427562 |
| NK,cells(Nos)_source |
LCK_ligand |
NK,cells(Nos)_target |
CD8 receptor_receptor |
8.656e-03 |
0.0 |
LCK |
Cell-Cell Contact |
PMID: 25427562 |
| CD4+,T-cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.073e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
5.288e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
2.277e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.240e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
6.025e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
2.459e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.198e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
5.238e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
2.373e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.238e-02 |
0.01 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
9.571e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
2.788e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-F_ligand |
NK,cells(Nos)_target |
CD8A_receptor |
1.336e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.444e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
7.092e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-A_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
3.045e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.662e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
8.049e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-B_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
3.280e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.607e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
7.026e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-C_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
3.169e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.659e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.256e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
3.704e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-F_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
3.311e-03 |
0.02 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-F_ligand |
NK,cells(Nos)_target |
CD8B_receptor |
1.809e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRK1_receptor |
1.415e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| Erythrocytes(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRK1_receptor |
1.084e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
KLRK1_receptor |
3.175e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| CD4+,T-cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD94:NKG2A_receptor |
7.831e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| Erythrocytes(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD94:NKG2A_receptor |
6.199e-03 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| NK,cells(Nos)_source |
HLA-E_ligand |
NK,cells(Nos)_target |
CD94:NKG2A_receptor |
1.782e-02 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| NK,cells(Nos)_source |
HLA-DPA1_ligand |
NK,cells(Nos)_target |
CD4_receptor |
3.466e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-DPB1_ligand |
NK,cells(Nos)_target |
CD4_receptor |
3.376e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-DRA_ligand |
NK,cells(Nos)_target |
CD4_receptor |
1.278e-03 |
0.03 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-DRB1_ligand |
NK,cells(Nos)_target |
CD4_receptor |
2.461e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
HLA-DRB5_ligand |
NK,cells(Nos)_target |
CD4_receptor |
7.821e-04 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
PECAM1_ligand |
Erythrocytes(Nos)_target |
PECAM1_receptor |
2.467e-04 |
0.0 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |