Sample overview

Project Name	TCGA-READ
GSE ID	GSE205506
GSM ID	GSM6213995
Cell Line	None
Tissue type	rectum
Disease Type	tumor
PMID	37172580
Initial gene number	33538
Initial cell number	6785
Post-QC gene number	9101
Post-QC cell number	118

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
B-cells(Nos)_source	MIF_ligand	Monocytes(Nos)_target	CD74_CXCR4_receptor	7.011e-05	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
Epithelial,cells(Nos)_source	MIF_ligand	Monocytes(Nos)_target	CD74_CXCR4_receptor	1.273e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
Monocytes(Nos)_source	MIF_ligand	Monocytes(Nos)_target	CD74_CXCR4_receptor	8.123e-05	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
B-cells(Nos)_source	MIF_ligand	Monocytes(Nos)_target	CD74_CD44_receptor	4.087e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Epithelial,cells(Nos)_source	MIF_ligand	Monocytes(Nos)_target	CD74_CD44_receptor	7.409e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Monocytes(Nos)_source	MIF_ligand	Monocytes(Nos)_target	CD74_CD44_receptor	4.740e-04	0.01	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Monocytes(Nos)_source	IL1B_ligand	Epithelial,cells(Nos)_target	IL1R2_receptor	7.677e-06	0.01	IL1	Secreted Signaling	KEGG: hsa04060
Monocytes(Nos)_source	IL1B_ligand	Monocytes(Nos)_target	IL1R2_receptor	1.416e-03	0.0	IL1	Secreted Signaling	KEGG: hsa04060
Monocytes(Nos)_source	COL4A1_ligand	Epithelial,cells(Nos)_target	ITGA1_ITGB1_receptor	1.523e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A1_ligand	Monocytes(Nos)_target	ITGA1_ITGB1_receptor	3.169e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	Epithelial,cells(Nos)_target	ITGA1_ITGB1_receptor	1.516e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	Monocytes(Nos)_target	ITGA1_ITGB1_receptor	3.154e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.470e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A1_ligand	Monocytes(Nos)_target	ITGA2_ITGB1_receptor	3.208e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.463e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	Monocytes(Nos)_target	ITGA2_ITGB1_receptor	3.193e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A1_ligand	B-cells(Nos)_target	CD44_receptor	1.661e-04	0.02	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A1_ligand	Monocytes(Nos)_target	CD44_receptor	9.507e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	B-cells(Nos)_target	CD44_receptor	1.654e-04	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	Monocytes(Nos)_target	CD44_receptor	9.463e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A1_ligand	B-cells(Nos)_target	SDC1_receptor	8.548e-05	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	B-cells(Nos)_target	SDC1_receptor	8.508e-05	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A1_ligand	Monocytes(Nos)_target	SDC4_receptor	1.381e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Monocytes(Nos)_source	COL4A2_ligand	Monocytes(Nos)_target	SDC4_receptor	1.374e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	APP_ligand	B-cells(Nos)_target	CD74_receptor	4.018e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Monocytes(Nos)_source	APP_ligand	B-cells(Nos)_target	CD74_receptor	2.515e-04	0.01	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	Monocytes(Nos)_target	CD74_receptor	8.105e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Monocytes(Nos)_source	APP_ligand	Monocytes(Nos)_target	CD74_receptor	5.081e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Monocytes(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	7.959e-08	0.02	CD46	Cell-Cell Contact	PMID: 23086448
Monocytes(Nos)_source	CD46_ligand	Monocytes(Nos)_target	JAG1_receptor	1.853e-07	0.01	CD46	Cell-Cell Contact	PMID: 23086448
Monocytes(Nos)_source	CD99_ligand	Monocytes(Nos)_target	CD99_receptor	3.850e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	9.100e-09	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Monocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.015e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Monocytes(Nos)_target	CDH1_receptor	1.015e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Monocytes(Nos)_source	CDH1_ligand	Monocytes(Nos)_target	CDH1_receptor	1.131e-08	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.011e-06	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Monocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.127e-06	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	CDH1_ligand	Monocytes(Nos)_target	ITGA2_ITGB1_receptor	2.211e-06	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Monocytes(Nos)_source	CDH1_ligand	Monocytes(Nos)_target	ITGA2_ITGB1_receptor	2.465e-06	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	EFNA1_ligand	B-cells(Nos)_target	EPHA2_receptor	6.753e-09	0.02	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA2_receptor	1.129e-06	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Monocytes(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA2_receptor	3.569e-09	0.04	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	HSC(Nos)_target	EPHA2_receptor	5.987e-09	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	Monocytes(Nos)_target	EPHA2_receptor	2.608e-08	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	B-cells(Nos)_target	EPHA4_receptor	5.984e-10	0.02	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	7.684e-07	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
HSC(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	5.166e-10	0.03	EPHA	Cell-Cell Contact	PMID: 15114347
Monocytes(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	2.430e-09	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	HSC(Nos)_target	EPHA4_receptor	5.290e-10	0.04	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	Monocytes(Nos)_target	EPHA4_receptor	3.404e-09	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	B-cells(Nos)_target	EPHA2_receptor	1.071e-08	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA2_receptor	1.791e-06	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
HSC(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA2_receptor	1.318e-09	0.04	EPHA	Cell-Cell Contact	PMID: 15114347
Monocytes(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA2_receptor	9.112e-09	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	HSC(Nos)_target	EPHA2_receptor	9.497e-09	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	Monocytes(Nos)_target	EPHA2_receptor	4.137e-08	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	B-cells(Nos)_target	EPHA4_receptor	9.491e-10	0.04	EPHA	Cell-Cell Contact	PMID: 15114347
B-cells(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	1.452e-09	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	1.219e-06	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
HSC(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	8.969e-10	0.01	EPHA	Cell-Cell Contact	PMID: 15114347
Monocytes(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA4_receptor	6.202e-09	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	HSC(Nos)_target	EPHA4_receptor	8.390e-10	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	Monocytes(Nos)_target	EPHA4_receptor	5.399e-09	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Monocytes(Nos)_source	MPZL1_ligand	B-cells(Nos)_target	MPZL1_receptor	1.119e-07	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Monocytes(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	9.722e-08	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
B-cells(Nos)_source	MPZL1_ligand	Monocytes(Nos)_target	MPZL1_receptor	1.119e-07	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Monocytes(Nos)_target	MPZL1_receptor	9.722e-08	0.03	MPZ	Cell-Cell Contact	KEGG: hsa04514
Monocytes(Nos)_source	MPZL1_ligand	Monocytes(Nos)_target	MPZL1_receptor	3.028e-06	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	JAG1_ligand	Monocytes(Nos)_target	NOTCH1_receptor	6.425e-10	0.01	NOTCH	Cell-Cell Contact	PMID: 22353464
Monocytes(Nos)_source	JAG1_ligand	Monocytes(Nos)_target	NOTCH1_receptor	1.496e-09	0.01	NOTCH	Cell-Cell Contact	PMID: 22353464