Sample overview
| Project Name | TCGA-READ |
| GSE ID | GSE205506 |
| GSM ID | GSM6213977 |
| Cell Line | None |
| Tissue type | colon |
| Disease Type | tumor |
| PMID | 37172580 |
| Initial gene number | 33538 |
| Initial cell number | 5067 |
| Post-QC gene number | 8691 |
| Post-QC cell number | 251 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Monocytes(Nos)_source | TGFB1_ligand | Monocytes(Nos)_target | TGFbR1_R2_receptor | 5.427e-06 | 0.02 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Monocytes(Poor)_source | TGFB1_ligand | Monocytes(Nos)_target | TGFbR1_R2_receptor | 1.215e-05 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Monocytes(Nos)_source | TGFB1_ligand | Monocytes(Poor)_target | TGFbR1_R2_receptor | 2.060e-05 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Monocytes(Poor)_source | TGFB1_ligand | Monocytes(Poor)_target | TGFbR1_R2_receptor | 4.609e-05 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Monocytes(Nos)_source | TGFB1_ligand | Monocytes(Nos)_target | ACVR1B_TGFbR2_receptor | 1.308e-06 | 0.01 | TGFb | Secreted Signaling | PMID: 27449815 |
| Monocytes(Poor)_source | TGFB1_ligand | Monocytes(Nos)_target | ACVR1B_TGFbR2_receptor | 2.929e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| Monocytes(Nos)_source | TGFB1_ligand | Monocytes(Poor)_target | ACVR1B_TGFbR2_receptor | 5.471e-06 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| Monocytes(Poor)_source | TGFB1_ligand | Monocytes(Poor)_target | ACVR1B_TGFbR2_receptor | 1.225e-05 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| Monocytes(Nos)_source | AREG_ligand | Monocytes(Good)_target | EGFR_ERBB2_receptor | 2.878e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Poor)_source | AREG_ligand | Monocytes(Good)_target | EGFR_ERBB2_receptor | 4.038e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | AREG_ligand | Monocytes(Nos)_target | EGFR_ERBB2_receptor | 1.305e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Poor)_source | AREG_ligand | Monocytes(Nos)_target | EGFR_ERBB2_receptor | 1.830e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | AREG_ligand | Monocytes(Poor)_target | EGFR_ERBB2_receptor | 1.342e-06 | 0.01 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Poor)_source | AREG_ligand | Monocytes(Poor)_target | EGFR_ERBB2_receptor | 1.883e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Epithelial,cells(Good)_target | EGFR_ERBB2_receptor | 9.238e-08 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Epithelial,cells(Nos)_target | EGFR_ERBB2_receptor | 3.330e-08 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Epithelial,cells(Poor)_target | EGFR_ERBB2_receptor | 6.959e-08 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Monocytes(Good)_target | EGFR_ERBB2_receptor | 3.060e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Monocytes(Nos)_target | EGFR_ERBB2_receptor | 1.387e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Monocytes(Poor)_target | EGFR_ERBB2_receptor | 1.427e-06 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | IL1B_ligand | Monocytes(Nos)_target | IL1R2_receptor | 2.069e-03 | 0.0 | IL1 | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Poor)_source | IL1B_ligand | Monocytes(Nos)_target | IL1R2_receptor | 8.853e-04 | 0.0 | IL1 | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Nos)_source | IL1B_ligand | Monocytes(Poor)_target | IL1R2_receptor | 1.680e-03 | 0.0 | IL1 | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Poor)_source | IL1B_ligand | Monocytes(Poor)_target | IL1R2_receptor | 7.157e-04 | 0.0 | IL1 | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Nos)_source | SPP1_ligand | Monocytes(Nos)_target | CD44_receptor | 4.368e-03 | 0.01 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Poor)_source | SPP1_ligand | Monocytes(Nos)_target | CD44_receptor | 1.180e-02 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Poor)_source | SPP1_ligand | Monocytes(Poor)_target | CD44_receptor | 8.553e-03 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Poor)_source | SPP1_ligand | Monocytes(Nos)_target | ITGAV_ITGB1_receptor | 7.604e-04 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Nos)_source | SPP1_ligand | Monocytes(Poor)_target | ITGAV_ITGB1_receptor | 7.970e-04 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Poor)_source | SPP1_ligand | Monocytes(Poor)_target | ITGAV_ITGB1_receptor | 2.306e-03 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Poor)_source | SPP1_ligand | Monocytes(Nos)_target | ITGAV_ITGB5_receptor | 3.055e-04 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Nos)_source | SPP1_ligand | Monocytes(Poor)_target | ITGAV_ITGB5_receptor | 3.507e-04 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Poor)_source | SPP1_ligand | Monocytes(Poor)_target | ITGAV_ITGB5_receptor | 1.022e-03 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Monocytes(Nos)_source | NAMPT_ligand | Monocytes(Good)_target | INSR_receptor | 2.895e-06 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Poor)_source | NAMPT_ligand | Monocytes(Good)_target | INSR_receptor | 2.556e-06 | 0.01 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | Monocytes(Nos)_target | INSR_receptor | 2.221e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Poor)_source | NAMPT_ligand | Monocytes(Nos)_target | INSR_receptor | 1.961e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | Monocytes(Poor)_target | INSR_receptor | 1.658e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Poor)_source | NAMPT_ligand | Monocytes(Poor)_target | INSR_receptor | 1.463e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Poor)_source | GRN_ligand | Monocytes(Nos)_target | SORT1_receptor | 7.031e-06 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Monocytes(Nos)_source | GRN_ligand | Monocytes(Poor)_target | SORT1_receptor | 7.405e-06 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Monocytes(Poor)_source | GRN_ligand | Monocytes(Poor)_target | SORT1_receptor | 2.827e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Epithelial,cells(Poor)_source | LGALS9_ligand | Monocytes(Good)_target | PTPRC_receptor | 3.759e-05 | 0.03 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| Monocytes(Poor)_source | LGALS9_ligand | Monocytes(Good)_target | PTPRC_receptor | 4.768e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| Monocytes(Poor)_source | LGALS9_ligand | Monocytes(Nos)_target | PTPRC_receptor | 8.937e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| Epithelial,cells(Poor)_source | LGALS9_ligand | Monocytes(Poor)_target | PTPRC_receptor | 1.903e-04 | 0.03 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| Monocytes(Poor)_source | LGALS9_ligand | Monocytes(Poor)_target | PTPRC_receptor | 2.422e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 30120235 |
| Monocytes(Poor)_source | LGALS9_ligand | Monocytes(Nos)_target | HAVCR2_receptor | 1.796e-04 | 0.04 | GALECTIN | Secreted Signaling | PMID: 27192565 |
| Epithelial,cells(Poor)_source | LGALS9_ligand | Monocytes(Poor)_target | HAVCR2_receptor | 6.656e-05 | 0.0 | GALECTIN | Secreted Signaling | PMID: 27192565 |
| Monocytes(Poor)_source | LGALS9_ligand | Monocytes(Poor)_target | HAVCR2_receptor | 8.561e-04 | 0.0 | GALECTIN | Secreted Signaling | PMID: 27192565 |
| Epithelial,cells(Poor)_source | LGALS9_ligand | Monocytes(Nos)_target | CD44_receptor | 2.467e-04 | 0.04 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| Monocytes(Poor)_source | LGALS9_ligand | Monocytes(Nos)_target | CD44_receptor | 3.117e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| Monocytes(Poor)_source | LGALS9_ligand | Monocytes(Poor)_target | CD44_receptor | 2.173e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| Monocytes(Poor)_source | FN1_ligand | Monocytes(Nos)_target | ITGAV_ITGB1_receptor | 9.355e-05 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | FN1_ligand | Monocytes(Poor)_target | ITGAV_ITGB1_receptor | 1.452e-05 | 0.04 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | FN1_ligand | Monocytes(Poor)_target | ITGAV_ITGB1_receptor | 2.871e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Good)_source | FN1_ligand | Monocytes(Nos)_target | ITGAV_ITGB8_receptor | 1.030e-08 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | FN1_ligand | Monocytes(Nos)_target | ITGAV_ITGB8_receptor | 4.893e-09 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | FN1_ligand | Monocytes(Nos)_target | ITGAV_ITGB8_receptor | 1.150e-08 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Good)_source | FN1_ligand | Monocytes(Nos)_target | ITGAV_ITGB8_receptor | 1.675e-07 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | FN1_ligand | Monocytes(Nos)_target | ITGAV_ITGB8_receptor | 5.614e-06 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | FN1_ligand | Monocytes(Nos)_target | ITGAV_ITGB8_receptor | 1.112e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | FN1_ligand | Monocytes(Nos)_target | CD44_receptor | 1.625e-03 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | FN1_ligand | Monocytes(Poor)_target | CD44_receptor | 1.126e-03 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | FN1_ligand | Monocytes(Nos)_target | SDC4_receptor | 3.877e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | FN1_ligand | Monocytes(Poor)_target | SDC4_receptor | 4.635e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Monocytes(Nos)_target | SDC4_receptor | 5.128e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | THBS1_ligand | Monocytes(Nos)_target | SDC4_receptor | 5.663e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Monocytes(Poor)_target | SDC4_receptor | 6.131e-05 | 0.01 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | THBS1_ligand | Monocytes(Poor)_target | SDC4_receptor | 6.771e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Monocytes(Good)_target | CD47_receptor | 5.931e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | THBS1_ligand | Monocytes(Good)_target | CD47_receptor | 6.549e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Monocytes(Nos)_target | CD47_receptor | 2.968e-05 | 0.02 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | THBS1_ligand | Monocytes(Nos)_target | CD47_receptor | 3.277e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Monocytes(Poor)_target | CD47_receptor | 9.088e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Poor)_source | THBS1_ligand | Monocytes(Poor)_target | CD47_receptor | 1.004e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Good)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 5.445e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 4.462e-05 | 0.01 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Poor)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 9.198e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Good)_source | ADGRE5_ligand | Monocytes(Poor)_target | CD55_receptor | 5.658e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | ADGRE5_ligand | Monocytes(Poor)_target | CD55_receptor | 4.635e-05 | 0.04 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Poor)_source | ADGRE5_ligand | Monocytes(Poor)_target | CD55_receptor | 9.554e-05 | 0.01 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 3.917e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Poor)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 3.720e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | CD99_ligand | Monocytes(Poor)_target | CD99_receptor | 3.720e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ITGB2_ligand | Monocytes(Nos)_target | ICAM1_receptor | 2.457e-04 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Poor)_source | ITGB2_ligand | Monocytes(Nos)_target | ICAM1_receptor | 6.674e-04 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ITGB2_ligand | Monocytes(Poor)_target | ICAM1_receptor | 2.302e-04 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Poor)_source | ITGB2_ligand | Monocytes(Poor)_target | ICAM1_receptor | 6.257e-04 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Good)_source | SEMA4D_ligand | Monocytes(Good)_target | PLXNB1_receptor | 2.953e-07 | 0.03 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Nos)_source | SEMA4D_ligand | Monocytes(Good)_target | PLXNB1_receptor | 8.669e-07 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Poor)_source | SEMA4D_ligand | Monocytes(Good)_target | PLXNB1_receptor | 1.478e-07 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Good)_source | SEMA4D_ligand | Monocytes(Nos)_target | PLXNB1_receptor | 9.526e-07 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Nos)_source | SEMA4D_ligand | Monocytes(Nos)_target | PLXNB1_receptor | 2.797e-06 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Poor)_source | SEMA4D_ligand | Monocytes(Nos)_target | PLXNB1_receptor | 4.769e-07 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Good)_source | SEMA4D_ligand | Monocytes(Poor)_target | PLXNB1_receptor | 7.242e-07 | 0.01 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Nos)_source | SEMA4D_ligand | Monocytes(Poor)_target | PLXNB1_receptor | 2.126e-06 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Poor)_source | SEMA4D_ligand | Monocytes(Poor)_target | PLXNB1_receptor | 3.625e-07 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Nos)_source | SEMA4D_ligand | Epithelial,cells(Good)_target | PLXNB2_receptor | 1.146e-09 | 0.02 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Good)_source | SEMA4D_ligand | Monocytes(Nos)_target | PLXNB2_receptor | 1.638e-09 | 0.01 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Nos)_source | SEMA4D_ligand | Monocytes(Nos)_target | PLXNB2_receptor | 4.807e-09 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Poor)_source | SEMA4D_ligand | Monocytes(Nos)_target | PLXNB2_receptor | 8.197e-10 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Good)_source | SEMA4D_ligand | Monocytes(Poor)_target | PLXNB2_receptor | 1.847e-09 | 0.02 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Nos)_source | SEMA4D_ligand | Monocytes(Poor)_target | PLXNB2_receptor | 5.422e-09 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Monocytes(Poor)_source | SEMA4D_ligand | Monocytes(Poor)_target | PLXNB2_receptor | 9.245e-10 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |