Sample overview

Project Name	TCGA-READ
GSE ID	GSE205506
GSM ID	GSM6213956
Cell Line	None
Tissue type	colon
Disease Type	tumor
PMID	37172580
Initial gene number	33538
Initial cell number	1666
Post-QC gene number	1361
Post-QC cell number	1125

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Adipocytes(Nos)_source	MIF_ligand	B-cells(Nos)_target	CD74_CD44_receptor	5.873e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
B-cells(Nos)_source	MIF_ligand	B-cells(Nos)_target	CD74_CD44_receptor	8.817e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	MIF_ligand	B-cells(Nos)_target	CD74_CD44_receptor	7.501e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Epithelial,cells(Nos)_source	MIF_ligand	B-cells(Nos)_target	CD74_CD44_receptor	5.681e-04	0.04	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Adipocytes(Nos)_source	MIF_ligand	CD4+,T-cells(Nos)_target	CD74_CD44_receptor	8.761e-05	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
B-cells(Nos)_source	MIF_ligand	CD4+,T-cells(Nos)_target	CD74_CD44_receptor	1.306e-04	0.04	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	MIF_ligand	CD4+,T-cells(Nos)_target	CD74_CD44_receptor	1.117e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Adipocytes(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	2.808e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
B-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	4.226e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	3.588e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Epithelial,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	2.725e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Adipocytes(Nos)_source	LGALS9_ligand	B-cells(Nos)_target	PTPRC_receptor	6.799e-04	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Epithelial,cells(Nos)_source	LGALS9_ligand	B-cells(Nos)_target	PTPRC_receptor	2.236e-03	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Adipocytes(Nos)_source	LGALS9_ligand	CD4+,T-cells(Nos)_target	PTPRC_receptor	3.285e-04	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Epithelial,cells(Nos)_source	LGALS9_ligand	CD4+,T-cells(Nos)_target	PTPRC_receptor	1.085e-03	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Adipocytes(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	PTPRC_receptor	7.863e-04	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Epithelial,cells(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	PTPRC_receptor	2.613e-03	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Adipocytes(Nos)_source	LGALS9_ligand	B-cells(Nos)_target	CD44_receptor	1.737e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	LGALS9_ligand	B-cells(Nos)_target	CD44_receptor	5.691e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Adipocytes(Nos)_source	LGALS9_ligand	CD4+,T-cells(Nos)_target	CD44_receptor	4.021e-05	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	LGALS9_ligand	CD4+,T-cells(Nos)_target	CD44_receptor	1.317e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Adipocytes(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	1.761e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	5.781e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Adipocytes(Nos)_source	APP_ligand	Adipocytes(Nos)_target	CD74_receptor	6.880e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	Adipocytes(Nos)_target	CD74_receptor	5.206e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Adipocytes(Nos)_source	APP_ligand	B-cells(Nos)_target	CD74_receptor	2.679e-03	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	B-cells(Nos)_target	CD74_receptor	2.041e-03	0.0	APP	Cell-Cell Contact	PMID: 19849849
Adipocytes(Nos)_source	APP_ligand	CD4+,T-cells(Nos)_target	CD74_receptor	2.726e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Adipocytes(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	6.354e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	4.636e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Adipocytes(Nos)_source	APP_ligand	Epithelial,cells(Nos)_target	CD74_receptor	3.476e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Adipocytes(Nos)_source	APP_ligand	HSC(Nos)_target	CD74_receptor	7.451e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	HSC(Nos)_target	CD74_receptor	5.548e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Adipocytes(Nos)_source	CD99_ligand	Adipocytes(Nos)_target	CD99_receptor	1.245e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
B-cells(Nos)_source	CD99_ligand	Adipocytes(Nos)_target	CD99_receptor	6.908e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	Adipocytes(Nos)_target	CD99_receptor	1.420e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CD99_ligand	Adipocytes(Nos)_target	CD99_receptor	6.704e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CD99_ligand	B-cells(Nos)_target	CD99_receptor	6.908e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	B-cells(Nos)_target	CD99_receptor	7.519e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.420e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
B-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	7.519e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.599e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	7.288e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Adipocytes(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	6.704e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	7.288e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514