Sample overview
| Project Name |
TCGA-READ
|
| GSE ID |
GSE199726
|
| GSM ID |
GSM5983201
|
| Cell Line |
None
|
| Tissue type |
metastasis: not metastasized
|
| Disease Type |
Colorectal cancer with lymph node metastasis
|
| PMID |
36805487
|
| Initial gene number |
33694
|
| Initial cell number |
8488
|
| Post-QC gene number |
10201
|
| Post-QC cell number |
2339
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| Fibroblasts(Nos)_source |
TGFB1_ligand |
Fibroblasts(Nos)_target |
TGFbR1_R2_receptor |
8.546e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Fibroblasts(Nos)_source |
TGFB1_ligand |
Fibroblasts(Nos)_target |
ACVR1B_TGFbR2_receptor |
2.367e-04 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 27449815 |
| Fibroblasts(Nos)_source |
TGFB1_ligand |
Fibroblasts(Nos)_target |
ACVR1_TGFbR_receptor |
6.435e-04 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 29376829 |
| Fibroblasts(Nos)_source |
INHBA_ligand |
Fibroblasts(Nos)_target |
ACVR1B_ACVR2A_receptor |
1.859e-06 |
0.0 |
ACTIVIN |
Secreted Signaling |
KEGG: hsa04350 |
| Fibroblasts(Nos)_source |
FGF1_ligand |
Fibroblasts(Nos)_target |
FGFR4_receptor |
6.455e-05 |
0.0 |
FGF |
Secreted Signaling |
PMC: 4393358 |
| Fibroblasts(Nos)_source |
FGF5_ligand |
Fibroblasts(Nos)_target |
FGFR4_receptor |
1.418e-04 |
0.0 |
FGF |
Secreted Signaling |
PMC: 4393358 |
| Fibroblasts(Nos)_source |
ANGPTL4_ligand |
Fibroblasts(Nos)_target |
ITGA5_ITGB1_receptor |
6.493e-03 |
0.0 |
ANGPTL |
Secreted Signaling |
PMID: 30049845 |
| Fibroblasts(Nos)_source |
ANGPTL4_ligand |
Fibroblasts(Nos)_target |
SDC2_receptor |
5.207e-04 |
0.0 |
ANGPTL |
Secreted Signaling |
PMID: 29017031 |
| Fibroblasts(Nos)_source |
ANGPTL4_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
2.086e-03 |
0.0 |
ANGPTL |
Secreted Signaling |
PMID: 29017031 |
| Fibroblasts(Nos)_source |
PRSS3_ligand |
Fibroblasts(Nos)_target |
F2R_receptor |
2.605e-03 |
0.0 |
PARs |
Secreted Signaling |
KEGG: hsa04080 |
| Fibroblasts(Nos)_source |
SEMA3C_ligand |
Fibroblasts(Nos)_target |
NRP1_PLXNA2_receptor |
6.802e-05 |
0.0 |
SEMA3 |
Secreted Signaling |
PMID: 27533782 |
| Fibroblasts(Nos)_source |
SEMA3C_ligand |
Fibroblasts(Nos)_target |
NRP2_PLXNA2_receptor |
2.506e-05 |
0.0 |
SEMA3 |
Secreted Signaling |
PMID: 27533782 |
| Fibroblasts(Nos)_source |
GAS6_ligand |
Fibroblasts(Nos)_target |
AXL_receptor |
5.132e-03 |
0.0 |
GAS |
Secreted Signaling |
PMID: 27801848 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
8.435e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
9.553e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
2.340e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
2.438e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
7.031e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
6.645e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
6.751e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
8.571e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
9.705e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
2.380e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
2.480e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
7.146e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
6.754e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
6.862e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
ITGA4_ITGB1_receptor |
4.241e-02 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
ITGA5_ITGB1_receptor |
1.037e-01 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
2.601e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA4_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
3.198e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
1.931e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
4.280e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMC1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
3.795e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
2.647e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA4_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
3.253e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
1.964e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
4.356e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMC1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
3.860e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA2_ligand |
Fibroblasts(Nos)_target |
ITGA7_ITGB1_receptor |
1.840e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA4_ligand |
Fibroblasts(Nos)_target |
ITGA7_ITGB1_receptor |
2.284e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB1_ligand |
Fibroblasts(Nos)_target |
ITGA7_ITGB1_receptor |
1.373e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB2_ligand |
Fibroblasts(Nos)_target |
ITGA7_ITGB1_receptor |
3.029e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMC1_ligand |
Fibroblasts(Nos)_target |
ITGA7_ITGB1_receptor |
2.716e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
ITGAV_ITGB1_receptor |
8.831e-02 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
5.422e-02 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
5.876e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
6.682e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.594e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.662e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
4.872e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
4.599e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
4.674e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.759e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA4_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
2.186e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.314e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
2.897e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMC1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
2.599e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
3.899e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
4.448e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
1.040e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
1.085e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
3.220e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
3.036e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
3.087e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
3.592e-02 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
4.252e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
2.296e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS1_ligand |
Fibroblasts(Nos)_target |
CD47_receptor |
2.468e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS2_ligand |
Fibroblasts(Nos)_target |
CD47_receptor |
1.332e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
ADGRE5_ligand |
Fibroblasts(Nos)_target |
CD55_receptor |
4.553e-04 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| Fibroblasts(Nos)_source |
CD46_ligand |
Fibroblasts(Nos)_target |
JAG1_receptor |
3.345e-06 |
0.0 |
CD46 |
Cell-Cell Contact |
PMID: 23086448 |
| Fibroblasts(Nos)_source |
CD99_ligand |
Fibroblasts(Nos)_target |
CD99_receptor |
1.339e-01 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Fibroblasts(Nos)_source |
CDH2_ligand |
Fibroblasts(Nos)_target |
CDH2_receptor |
2.307e-07 |
0.0 |
CDH |
Cell-Cell Contact |
KEGG: hsa04514 |
| Fibroblasts(Nos)_source |
CLDN11_ligand |
Fibroblasts(Nos)_target |
CLDN11_receptor |
3.207e-02 |
0.0 |
CLDN |
Cell-Cell Contact |
KEGG: hsa04514 |
| Fibroblasts(Nos)_source |
EFNA4_ligand |
Fibroblasts(Nos)_target |
EPHA2_receptor |
6.457e-08 |
0.0 |
EPHA |
Cell-Cell Contact |
PMID: 15114347 |
| Fibroblasts(Nos)_source |
EFNA5_ligand |
Fibroblasts(Nos)_target |
EPHA2_receptor |
2.534e-07 |
0.0 |
EPHA |
Cell-Cell Contact |
PMID: 15114347 |
| Fibroblasts(Nos)_source |
EFNA5_ligand |
Fibroblasts(Nos)_target |
EPHB2_receptor |
1.475e-06 |
0.0 |
EPHA |
Cell-Cell Contact |
PMID:15107857; PMID: 15114347 |
| Fibroblasts(Nos)_source |
EFNB2_ligand |
Fibroblasts(Nos)_target |
EPHB2_receptor |
5.872e-06 |
0.0 |
EPHB |
Cell-Cell Contact |
PMID: 15114347 |
| Fibroblasts(Nos)_source |
EFNB2_ligand |
Fibroblasts(Nos)_target |
EPHB4_receptor |
1.895e-06 |
0.0 |
EPHB |
Cell-Cell Contact |
PMID: 15114347 |
| Fibroblasts(Nos)_source |
MPZL1_ligand |
Fibroblasts(Nos)_target |
MPZL1_receptor |
2.238e-03 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Fibroblasts(Nos)_source |
JAG1_ligand |
Fibroblasts(Nos)_target |
NOTCH2_receptor |
2.030e-06 |
0.0 |
NOTCH |
Cell-Cell Contact |
PMID: 22353464 |
| Fibroblasts(Nos)_source |
JAG1_ligand |
Fibroblasts(Nos)_target |
NOTCH3_receptor |
2.444e-08 |
0.0 |
NOTCH |
Cell-Cell Contact |
PMID: 22353464 |