Sample overview
| Project Name |
TCGA-READ
|
| GSE ID |
GSE199726
|
| GSM ID |
GSM5983198
|
| Cell Line |
None
|
| Tissue type |
metastasis: lymphatic metastasis
|
| Disease Type |
Colorectal cancer with lymph node metastasis
|
| PMID |
36805487
|
| Initial gene number |
33694
|
| Initial cell number |
9547
|
| Post-QC gene number |
10454
|
| Post-QC cell number |
770
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| Fibroblasts(Nos)_source |
TGFB1_ligand |
Fibroblasts(Nos)_target |
ACVR1_TGFbR_receptor |
1.461e-03 |
0.01 |
TGFb |
Secreted Signaling |
PMID: 29376829 |
| Fibroblasts(Nos)_source |
FGF2_ligand |
Fibroblasts(Nos)_target |
FGFR1_receptor |
2.114e-03 |
0.0 |
FGF |
Secreted Signaling |
PMC: 4393358 |
| Fibroblasts(Nos)_source |
FGF7_ligand |
Fibroblasts(Nos)_target |
FGFR1_receptor |
7.259e-03 |
0.0 |
FGF |
Secreted Signaling |
PMC: 4393358 |
| Fibroblasts(Nos)_source |
NAMPT_ligand |
Fibroblasts(Nos)_target |
INSR_receptor |
5.029e-04 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Fibroblasts(Nos)_source |
NAMPT_ligand |
Fibroblasts(Nos)_target |
ITGA5_ITGB1_receptor |
5.957e-02 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Fibroblasts(Nos)_source |
ANGPTL4_ligand |
Fibroblasts(Nos)_target |
ITGA5_ITGB1_receptor |
7.862e-03 |
0.0 |
ANGPTL |
Secreted Signaling |
PMID: 30049845 |
| Fibroblasts(Nos)_source |
ANGPTL4_ligand |
Fibroblasts(Nos)_target |
SDC2_receptor |
7.703e-04 |
0.0 |
ANGPTL |
Secreted Signaling |
PMID: 29017031 |
| Fibroblasts(Nos)_source |
ANGPTL4_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
2.760e-03 |
0.0 |
ANGPTL |
Secreted Signaling |
PMID: 29017031 |
| Fibroblasts(Nos)_source |
MDK_ligand |
Fibroblasts(Nos)_target |
SDC2_receptor |
1.031e-03 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Nos)_source |
MDK_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
3.693e-03 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Nos)_source |
MDK_ligand |
Fibroblasts(Nos)_target |
ITGA4_ITGB1_receptor |
3.834e-03 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Nos)_source |
MDK_ligand |
Fibroblasts(Nos)_target |
LRP1_receptor |
4.999e-03 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Nos)_source |
SEMA3C_ligand |
Fibroblasts(Nos)_target |
NRP1_PLXNA2_receptor |
8.831e-05 |
0.0 |
SEMA3 |
Secreted Signaling |
PMID: 27533782 |
| Fibroblasts(Nos)_source |
SEMA3C_ligand |
Fibroblasts(Nos)_target |
NRP2_PLXNA2_receptor |
4.960e-05 |
0.0 |
SEMA3 |
Secreted Signaling |
PMID: 27533782 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
1.449e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
1.550e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
3.342e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
3.410e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
1.171e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
1.105e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
1.086e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
1.643e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
1.754e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
3.871e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
3.949e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
1.335e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
1.261e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
1.240e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
ITGA4_ITGB1_receptor |
6.875e-02 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
ITGA5_ITGB1_receptor |
1.663e-01 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
6.646e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA2_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
1.801e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA4_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
2.958e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
3.895e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMC1_ligand |
Fibroblasts(Nos)_target |
ITGA1_ITGB1_receptor |
6.326e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
7.738e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA2_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
2.093e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA4_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
3.428e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
4.506e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMC1_ligand |
Fibroblasts(Nos)_target |
ITGA2_ITGB1_receptor |
7.285e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
ITGAV_ITGB1_receptor |
1.449e-01 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.089e-01 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.296e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.388e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
2.940e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
3.001e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.043e-01 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
9.834e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
9.658e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
5.825e-03 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA2_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
1.581e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMA4_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
2.601e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMB1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
3.429e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
LAMC1_ligand |
Fibroblasts(Nos)_target |
CD44_receptor |
5.590e-02 |
0.0 |
LAMININ |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
7.984e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL1A2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
8.595e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
1.721e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL4A2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
1.757e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
6.346e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
5.962e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
COL6A3_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
5.850e-02 |
0.0 |
COLLAGEN |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
FN1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
6.641e-02 |
0.0 |
FN1 |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS1_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
1.335e-02 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS2_ligand |
Fibroblasts(Nos)_target |
SDC4_receptor |
2.001e-02 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS1_ligand |
Fibroblasts(Nos)_target |
CD47_receptor |
7.537e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
THBS2_ligand |
Fibroblasts(Nos)_target |
CD47_receptor |
1.134e-02 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Fibroblasts(Nos)_source |
CD99_ligand |
Fibroblasts(Nos)_target |
CD99_receptor |
1.813e-01 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Fibroblasts(Nos)_source |
EFNB2_ligand |
Fibroblasts(Nos)_target |
EPHA4_receptor |
1.723e-06 |
0.0 |
EPHB |
Cell-Cell Contact |
PMID: 15114347 |
| Fibroblasts(Nos)_source |
EFNB2_ligand |
Fibroblasts(Nos)_target |
EPHB2_receptor |
1.092e-05 |
0.0 |
EPHB |
Cell-Cell Contact |
PMID: 15114347 |
| Fibroblasts(Nos)_source |
MPZL1_ligand |
Fibroblasts(Nos)_target |
MPZL1_receptor |
3.191e-03 |
0.03 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Fibroblasts(Nos)_source |
ITGA4_ITGB1_ligand |
Fibroblasts(Nos)_target |
VCAM1_receptor |
3.280e-03 |
0.0 |
VCAM |
Cell-Cell Contact |
KEGG: hsa04514 |