Sample overview

Project Name	TCGA-PRAD
GSE ID	GSE237602
GSM ID	GSM7634635
Cell Line	PC44
Tissue type	None
Disease Type	prostate cancer
PMID	\
Initial gene number	36601
Initial cell number	10806
Post-QC gene number	11060
Post-QC cell number	1437

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	BMP7_ligand	Epithelial,cells(Nos)_target	ACVR1_BMPR2_receptor	7.606e-06	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	BMP7_ligand	Epithelial,cells(Nos)_target	BMPR1B_BMPR2_receptor	5.520e-05	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	GDF15_ligand	Epithelial,cells(Nos)_target	TGFBR2_receptor	2.549e-04	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_receptor	1.886e-06	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Nos)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_ERBB2_receptor	2.571e-06	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Nos)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	4.808e-05	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	VTN_ligand	Epithelial,cells(Nos)_target	ITGAV_ITGB1_receptor	3.374e-05	VTN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	VTN_ligand	Epithelial,cells(Nos)_target	ITGAV_ITGB5_receptor	1.280e-05	VTN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	1.145e-04	THBS	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	4.207e-06	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	CD47_receptor	2.052e-04	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	CADM1_ligand	Epithelial,cells(Nos)_target	CADM1_receptor	1.056e-04	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	1.199e-06	CD46	Cell-Cell Contact	PMID: 23086448
Epithelial,cells(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	3.940e-02	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH2_ligand	Epithelial,cells(Nos)_target	CDH2_receptor	1.195e-07	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	3.871e-04	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	6.065e-04	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	2.900e-04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	JAG1_ligand	Epithelial,cells(Nos)_target	NOTCH1_receptor	2.738e-09	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG1_ligand	Epithelial,cells(Nos)_target	NOTCH3_receptor	6.931e-09	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	1.053e-08	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	SEMA4D_ligand	Epithelial,cells(Nos)_target	PLXNB1_receptor	1.573e-09	SEMA4	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA4D_ligand	Epithelial,cells(Nos)_target	PLXNB2_receptor	1.106e-10	SEMA4	Cell-Cell Contact	PMID: 27533782