Sample overview

Project Name	TCGA-PRAD
GSE ID	GSE237602
GSM ID	GSM7634634
Cell Line	LuCaP 145.2
Tissue type	None
Disease Type	prostate cancer
PMID	\
Initial gene number	33538
Initial cell number	8343
Post-QC gene number	11181
Post-QC cell number	854

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	BMP7_ligand	Epithelial,cells(Nos)_target	ACVR1_ACVR2A_receptor	2.081e-07	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	BMP7_ligand	Erythrocytes(Nos)_target	ACVR1_ACVR2A_receptor	6.321e-08	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	BMP7_ligand	Epithelial,cells(Nos)_target	ACVR1_ACVR2B_receptor	3.035e-07	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	BMP7_ligand	Erythrocytes(Nos)_target	ACVR1_ACVR2B_receptor	2.315e-07	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	BMP7_ligand	Epithelial,cells(Nos)_target	ACVR1_BMPR2_receptor	2.238e-07	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	BMP7_ligand	Erythrocytes(Nos)_target	ACVR1_BMPR2_receptor	7.430e-08	0.0	BMP	Secreted Signaling	KEGG: hsa04350; PMID:26893264
Epithelial,cells(Nos)_source	INHBA_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2A_receptor	4.604e-08	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04350
Erythrocytes(Nos)_source	INHBA_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2A_receptor	3.046e-09	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	INHBA_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2A_receptor	5.492e-09	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	INHBA_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	6.713e-08	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04351
Erythrocytes(Nos)_source	INHBA_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	4.441e-09	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04351
Epithelial,cells(Nos)_source	INHBA_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2B_receptor	2.012e-08	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04351
Epithelial,cells(Nos)_source	INHBB_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2A_receptor	5.355e-07	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04352
Epithelial,cells(Nos)_source	INHBB_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2A_receptor	6.389e-08	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04352
Epithelial,cells(Nos)_source	INHBB_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	7.809e-07	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04353
Epithelial,cells(Nos)_source	INHBB_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2B_receptor	2.340e-07	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04353
Epithelial,cells(Nos)_source	INHBE_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2A_receptor	5.988e-07	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04360
Epithelial,cells(Nos)_source	INHBE_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2A_receptor	7.143e-08	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04360
Epithelial,cells(Nos)_source	INHBE_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	8.731e-07	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04361
Epithelial,cells(Nos)_source	INHBE_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2B_receptor	2.616e-07	0.0	ACTIVIN	Secreted Signaling	KEGG: hsa04361
Epithelial,cells(Nos)_source	Activin AB_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2A_receptor	1.570e-07	0.0	ACTIVIN	Secreted Signaling	PMID: 2457849; PMID: 22991378
Epithelial,cells(Nos)_source	Activin AB_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2A_receptor	1.873e-08	0.0	ACTIVIN	Secreted Signaling	PMID: 2457849; PMID: 22991378
Epithelial,cells(Nos)_source	Activin AB_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	2.290e-07	0.0	ACTIVIN	Secreted Signaling	PMID: 2457849; PMID: 22991378
Epithelial,cells(Nos)_source	Activin AB_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2B_receptor	6.861e-08	0.0	ACTIVIN	Secreted Signaling	PMID: 2457849; PMID: 22991378
Epithelial,cells(Nos)_source	WNT4_ligand	Epithelial,cells(Nos)_target	FZD3_LRP5_receptor	2.075e-05	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	WNT4_ligand	Epithelial,cells(Nos)_target	FZD6_LRP5_receptor	2.432e-05	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	WNT4_ligand	Epithelial,cells(Nos)_target	FZD3_LRP6_receptor	1.915e-06	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	WNT4_ligand	Epithelial,cells(Nos)_target	FZD6_LRP6_receptor	2.244e-06	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	FGF7_ligand	Epithelial,cells(Nos)_target	FGFR1_receptor	8.386e-06	0.0	FGF	Secreted Signaling	PMC: 4393358
Epithelial,cells(Nos)_source	FGF7_ligand	Erythrocytes(Nos)_target	FGFR1_receptor	6.074e-07	0.0	FGF	Secreted Signaling	PMC: 4393358
Epithelial,cells(Nos)_source	FGF9_ligand	Epithelial,cells(Nos)_target	FGFR1_receptor	1.668e-05	0.0	FGF	Secreted Signaling	PMC: 4393358
Erythrocytes(Nos)_source	FGF9_ligand	Epithelial,cells(Nos)_target	FGFR1_receptor	1.243e-06	0.02	FGF	Secreted Signaling	PMC: 4393358
Epithelial,cells(Nos)_source	FGF9_ligand	Erythrocytes(Nos)_target	FGFR1_receptor	1.208e-06	0.02	FGF	Secreted Signaling	PMC: 4393358
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	2.841e-06	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Erythrocytes(Nos)_target	INSR_receptor	2.310e-06	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	4.107e-05	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	1.830e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	1.933e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	8.805e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	NCL_receptor	4.008e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	NCL_receptor	1.872e-02	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	POMC_ligand	Epithelial,cells(Nos)_target	OPRD1_receptor	1.282e-07	0.0	OPIOID	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	POMC_ligand	Erythrocytes(Nos)_target	OPRD1_receptor	4.828e-07	0.0	OPIOID	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	1.178e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	1.485e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Erythrocytes(Nos)_target	PARD3_receptor	2.390e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	KITLG_ligand	Epithelial,cells(Nos)_target	KIT_receptor	8.382e-07	0.0	KIT	Secreted Signaling	KEGG: hsa04080
Erythrocytes(Nos)_source	KITLG_ligand	Epithelial,cells(Nos)_target	KIT_receptor	6.183e-08	0.0	KIT	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	KITLG_ligand	Erythrocytes(Nos)_target	KIT_receptor	9.119e-07	0.0	KIT	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	8.321e-05	0.0	GRN	Secreted Signaling	PMID: 29555433
Erythrocytes(Nos)_source	GRN_ligand	Epithelial,cells(Nos)_target	SORT1_receptor	1.121e-04	0.0	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	GRN_ligand	Erythrocytes(Nos)_target	SORT1_receptor	1.394e-05	0.01	GRN	Secreted Signaling	PMID: 29555433
Epithelial,cells(Nos)_source	COL4A2_ligand	Epithelial,cells(Nos)_target	CD44_receptor	2.446e-07	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL4A2_ligand	Erythrocytes(Nos)_target	CD44_receptor	5.780e-07	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL4A2_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	1.246e-06	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	CADM1_ligand	Epithelial,cells(Nos)_target	CADM1_receptor	1.312e-03	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Epithelial,cells(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	2.582e-07	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Erythrocytes(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	3.069e-07	0.01	CD46	Cell-Cell Contact	PMID: 23086448
Epithelial,cells(Nos)_source	CD46_ligand	Erythrocytes(Nos)_target	JAG1_receptor	9.154e-07	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Epithelial,cells(Nos)_source	CDH2_ligand	Epithelial,cells(Nos)_target	CDH2_receptor	1.361e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	9.356e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	2.742e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	2.742e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	DSC2_ligand	Epithelial,cells(Nos)_target	DSG2_receptor	2.437e-05	0.0	DESMOSOME	Cell-Cell Contact	PMID: 27298358
Epithelial,cells(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA7_receptor	1.558e-06	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Erythrocytes(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA7_receptor	1.105e-08	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA1_ligand	Erythrocytes(Nos)_target	EPHA7_receptor	1.273e-08	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA7_receptor	3.311e-07	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Erythrocytes(Nos)_source	EFNA4_ligand	Epithelial,cells(Nos)_target	EPHA7_receptor	2.318e-08	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA4_ligand	Erythrocytes(Nos)_target	EPHA7_receptor	2.705e-09	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	JAM3_ligand	Epithelial,cells(Nos)_target	JAM3_receptor	5.272e-07	0.0	JAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	5.569e-05	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	8.129e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Erythrocytes(Nos)_target	MPZL1_receptor	8.129e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	NCAM1_ligand	Epithelial,cells(Nos)_target	FGFR1_receptor	2.853e-05	0.0	NCAM	Cell-Cell Contact	PMID: 12791257
Epithelial,cells(Nos)_source	NCAM1_ligand	Epithelial,cells(Nos)_target	NCAM1_receptor	4.410e-05	0.0	NCAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	NEGR1_ligand	Epithelial,cells(Nos)_target	NEGR1_receptor	1.463e-05	0.0	NEGR	Cell-Cell Contact	KEGG: hsa04514