Sample overview
| Project Name | TCGA-PRAD |
| GSE ID | GSE237602 |
| GSM ID | GSM7634630 |
| Cell Line | PC35-2 |
| Tissue type | None |
| Disease Type | prostate cancer |
| PMID | \ |
| Initial gene number | 36601 |
| Initial cell number | 8557 |
| Post-QC gene number | 11013 |
| Post-QC cell number | 7621 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Neurons(Nos)_source | BMP2_ligand | Epithelial,cells(Nos)_target | BMPR1B_ACVR2A_receptor | 3.588e-04 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Neurons(Nos)_source | BMP2_ligand | Epithelial,cells(Nos)_target | BMPR1B_ACVR2B_receptor | 9.451e-04 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Neurons(Nos)_source | BMP2_ligand | Neurons(Nos)_target | BMPR1B_ACVR2B_receptor | 3.772e-04 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Epithelial,cells(Nos)_source | BMP2_ligand | Neurons(Nos)_target | BMPR1B_BMPR2_receptor | 2.087e-03 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Neurons(Nos)_source | BMP2_ligand | Neurons(Nos)_target | BMPR1B_BMPR2_receptor | 8.550e-04 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Epithelial,cells(Nos)_source | GDF11_ligand | Epithelial,cells(Nos)_target | TGFBR1_ACVR2A_receptor | 1.733e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | GDF11_ligand | Epithelial,cells(Nos)_target | TGFBR1_ACVR2B_receptor | 4.577e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | GDF11_ligand | Neurons(Nos)_target | TGFBR1_ACVR2B_receptor | 1.735e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | GDF11_ligand | Epithelial,cells(Nos)_target | ACVR1B_ACVR2B_receptor | 1.581e-03 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | GDF11_ligand | Neurons(Nos)_target | ACVR1B_ACVR2B_receptor | 6.218e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | INHBA_ligand | Epithelial,cells(Nos)_target | ACVR1B_ACVR2A_receptor | 2.163e-05 | 0.0 | ACTIVIN | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | INHBA_ligand | Neurons(Nos)_target | ACVR1B_ACVR2B_receptor | 2.248e-05 | 0.0 | ACTIVIN | Secreted Signaling | KEGG: hsa04351 |
| Erythrocytes(Nos)_source | TNFSF12_ligand | Epithelial,cells(Nos)_target | TNFRSF12A_receptor | 6.526e-07 | 0.02 | TWEAK | Secreted Signaling | KEGG: hsa04060 |
| Erythrocytes(Nos)_source | TNFSF12_ligand | Erythrocytes(Nos)_target | TNFRSF12A_receptor | 6.367e-09 | 0.02 | TWEAK | Secreted Signaling | KEGG: hsa04060 |
| Erythrocytes(Nos)_source | TNFSF12_ligand | Neurons(Nos)_target | TNFRSF12A_receptor | 1.917e-07 | 0.02 | TWEAK | Secreted Signaling | KEGG: hsa04060 |
| Neurons(Nos)_source | NAMPT_ligand | Epithelial,cells(Nos)_target | INSR_receptor | 1.870e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Neurons(Nos)_source | NAMPT_ligand | Neurons(Nos)_target | INSR_receptor | 1.364e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Neurons(Nos)_source | GRN_ligand | Epithelial,cells(Nos)_target | SORT1_receptor | 2.014e-04 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Epithelial,cells(Nos)_source | GRN_ligand | Erythrocytes(Nos)_target | SORT1_receptor | 1.677e-05 | 0.03 | GRN | Secreted Signaling | PMID: 29555433 |
| Erythrocytes(Nos)_source | GRN_ligand | Erythrocytes(Nos)_target | SORT1_receptor | 2.181e-07 | 0.02 | GRN | Secreted Signaling | PMID: 29555433 |
| Neurons(Nos)_source | GRN_ligand | Erythrocytes(Nos)_target | SORT1_receptor | 7.579e-06 | 0.02 | GRN | Secreted Signaling | PMID: 29555433 |
| Neurons(Nos)_source | GRN_ligand | Neurons(Nos)_target | SORT1_receptor | 7.583e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | ITGA3_ITGB1_receptor | 2.180e-07 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 6.564e-05 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 1.120e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | ITGA6_ITGB1_receptor | 7.151e-07 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Neurons(Nos)_target | ITGA6_ITGB1_receptor | 2.459e-05 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Neurons(Nos)_target | ITGA6_ITGB1_receptor | 4.194e-04 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 3.985e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 5.504e-08 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 1.495e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | THBS1_ligand | Epithelial,cells(Nos)_target | CD47_receptor | 2.185e-05 | 0.04 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | CD47_receptor | 2.281e-05 | 0.03 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | CD47_receptor | 3.148e-07 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Neurons(Nos)_target | CD47_receptor | 7.239e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | THBS1_ligand | Neurons(Nos)_target | CD47_receptor | 9.989e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | THBS1_ligand | Neurons(Nos)_target | CD47_receptor | 2.715e-04 | 0.02 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | AGRN_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 1.128e-05 | 0.0 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | AGRN_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 1.407e-07 | 0.0 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | AGRN_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 4.562e-06 | 0.0 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | AGRN_ligand | Neurons(Nos)_target | DAG1_receptor | 1.213e-04 | 0.03 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | AGRN_ligand | Neurons(Nos)_target | DAG1_receptor | 4.908e-05 | 0.0 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | DAG1_receptor | 7.509e-06 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 1.271e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 3.138e-07 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 5.334e-06 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Neurons(Nos)_target | DAG1_receptor | 3.383e-06 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Neurons(Nos)_target | DAG1_receptor | 5.740e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | CADM1_ligand | Epithelial,cells(Nos)_target | CADM1_receptor | 4.913e-04 | 0.0 | CADM | Cell-Cell Contact | PMID: 24503895 |
| Neurons(Nos)_source | CD99_ligand | Epithelial,cells(Nos)_target | CD99_receptor | 2.563e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CD99_ligand | Neurons(Nos)_target | CD99_receptor | 2.563e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CD99_ligand | Neurons(Nos)_target | CD99_receptor | 1.031e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CD99_ligand | Neurons(Nos)_target | CD99L2_receptor | 2.920e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CD99_ligand | Neurons(Nos)_target | CD99L2_receptor | 1.184e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CDH2_ligand | Epithelial,cells(Nos)_target | CDH2_receptor | 4.246e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | CDH1_ligand | Epithelial,cells(Nos)_target | CDH1_receptor | 4.869e-08 | 0.02 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CDH1_ligand | Erythrocytes(Nos)_target | CDH1_receptor | 4.869e-08 | 0.02 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | CDH1_ligand | Erythrocytes(Nos)_target | CDH1_receptor | 1.535e-09 | 0.02 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH1_ligand | Erythrocytes(Nos)_target | CDH1_receptor | 1.857e-08 | 0.02 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | CDH1_ligand | Neurons(Nos)_target | CDH1_receptor | 1.857e-08 | 0.02 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | F11R_ligand | Epithelial,cells(Nos)_target | F11R_receptor | 2.061e-05 | 0.03 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | F11R_ligand | Erythrocytes(Nos)_target | F11R_receptor | 2.061e-05 | 0.03 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | F11R_ligand | Erythrocytes(Nos)_target | F11R_receptor | 4.218e-07 | 0.03 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | F11R_ligand | Erythrocytes(Nos)_target | F11R_receptor | 7.720e-06 | 0.03 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | F11R_ligand | Neurons(Nos)_target | F11R_receptor | 7.720e-06 | 0.03 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | MPZL1_ligand | Epithelial,cells(Nos)_target | MPZL1_receptor | 6.472e-06 | 0.03 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | MPZL1_ligand | Erythrocytes(Nos)_target | MPZL1_receptor | 6.472e-06 | 0.03 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | MPZL1_ligand | Erythrocytes(Nos)_target | MPZL1_receptor | 1.410e-07 | 0.03 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | MPZL1_ligand | Erythrocytes(Nos)_target | MPZL1_receptor | 2.533e-06 | 0.03 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | MPZL1_ligand | Neurons(Nos)_target | MPZL1_receptor | 2.533e-06 | 0.03 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | NCAM1_ligand | Epithelial,cells(Nos)_target | NCAM1_receptor | 1.915e-02 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | NECTIN3_ligand | Epithelial,cells(Nos)_target | PVR_receptor | 2.950e-06 | 0.0 | NECTIN | Cell-Cell Contact | PMID: 23027581 |
| Erythrocytes(Nos)_source | NECTIN3_ligand | Erythrocytes(Nos)_target | PVR_receptor | 2.087e-08 | 0.03 | NECTIN | Cell-Cell Contact | PMID: 23027581 |
| Erythrocytes(Nos)_source | NECTIN3_ligand | Neurons(Nos)_target | PVR_receptor | 2.322e-06 | 0.0 | NECTIN | Cell-Cell Contact | PMID: 23027581 |
| Neurons(Nos)_source | OCLN_ligand | Epithelial,cells(Nos)_target | OCLN_receptor | 8.490e-09 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | OCLN_ligand | Erythrocytes(Nos)_target | OCLN_receptor | 1.408e-10 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | OCLN_ligand | Neurons(Nos)_target | OCLN_receptor | 8.490e-09 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | OCLN_ligand | Neurons(Nos)_target | OCLN_receptor | 1.408e-10 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | OCLN_ligand | Neurons(Nos)_target | OCLN_receptor | 4.358e-09 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | PTPRM_ligand | Erythrocytes(Nos)_target | PTPRM_receptor | 2.788e-09 | 0.01 | PTPRM | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | SEMA4D_ligand | Epithelial,cells(Nos)_target | PLXNB1_receptor | 2.585e-08 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Epithelial,cells(Nos)_source | SEMA4D_ligand | Erythrocytes(Nos)_target | PLXNB1_receptor | 1.529e-08 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Erythrocytes(Nos)_source | SEMA4D_ligand | Erythrocytes(Nos)_target | PLXNB1_receptor | 5.385e-09 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA4D_ligand | Erythrocytes(Nos)_target | PLXNB1_receptor | 7.130e-09 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Erythrocytes(Nos)_source | SEMA4D_ligand | Neurons(Nos)_target | PLXNB1_receptor | 1.206e-08 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA4D_ligand | Neurons(Nos)_target | PLXNB1_receptor | 1.597e-08 | 0.02 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Erythrocytes(Nos)_source | SEMA4D_ligand | Epithelial,cells(Nos)_target | PLXNB2_receptor | 8.372e-07 | 0.01 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Erythrocytes(Nos)_source | SEMA4D_ligand | Erythrocytes(Nos)_target | PLXNB2_receptor | 9.084e-09 | 0.01 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Erythrocytes(Nos)_source | SEMA4D_ligand | Neurons(Nos)_target | PLXNB2_receptor | 3.819e-07 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA4D_ligand | Neurons(Nos)_target | PLXNB2_receptor | 5.057e-07 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA6A_ligand | Neurons(Nos)_target | PLXNA2_receptor | 3.146e-05 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |