Sample overview
| Project Name | TCGA-PRAD |
| GSE ID | GSE237602 |
| GSM ID | GSM7634627 |
| Cell Line | PC35-1 |
| Tissue type | None |
| Disease Type | prostate cancer |
| PMID | \ |
| Initial gene number | 36601 |
| Initial cell number | 6587 |
| Post-QC gene number | 10304 |
| Post-QC cell number | 5665 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Epithelial,cells(Nos)_source | BMP2_ligand | Epithelial,cells(Nos)_target | BMPR1B_ACVR2B_receptor | 2.154e-03 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Epithelial,cells(Nos)_source | BMP2_ligand | Epithelial,cells(Nos)_target | BMPR1B_BMPR2_receptor | 4.707e-03 | 0.0 | BMP | Secreted Signaling | KEGG: hsa04350; PMID:26893264 |
| Epithelial,cells(Nos)_source | GDF11_ligand | Epithelial,cells(Nos)_target | TGFBR1_ACVR2B_receptor | 2.600e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | GDF11_ligand | Epithelial,cells(Nos)_target | ACVR1B_ACVR2B_receptor | 8.604e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Erythrocytes(Nos)_source | NAMPT_ligand | Epithelial,cells(Nos)_target | INSR_receptor | 1.911e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Epithelial,cells(Nos)_source | NAMPT_ligand | Erythrocytes(Nos)_target | INSR_receptor | 1.744e-05 | 0.01 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Erythrocytes(Nos)_source | NAMPT_ligand | Erythrocytes(Nos)_target | INSR_receptor | 9.457e-07 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Neurons(Nos)_source | NAMPT_ligand | Erythrocytes(Nos)_target | INSR_receptor | 5.153e-06 | 0.01 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Epithelial,cells(Nos)_source | NAMPT_ligand | Neurons(Nos)_target | INSR_receptor | 1.268e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Erythrocytes(Nos)_source | NAMPT_ligand | Neurons(Nos)_target | INSR_receptor | 6.875e-06 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Erythrocytes(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 3.204e-07 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 2.493e-06 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Erythrocytes(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | SDC2_receptor | 2.370e-07 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | SDC2_receptor | 1.844e-06 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 4.342e-04 | 0.01 | MK | Secreted Signaling | PMID: 28356350 |
| Erythrocytes(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | ITGA6_ITGB1_receptor | 1.806e-06 | 0.02 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | ITGA6_ITGB1_receptor | 1.407e-05 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Neurons(Nos)_target | ITGA6_ITGB1_receptor | 1.321e-04 | 0.01 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Epithelial,cells(Nos)_target | NCL_receptor | 1.108e-03 | 0.01 | MK | Secreted Signaling | PMID: 28356350 |
| Erythrocytes(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | NCL_receptor | 5.236e-06 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | NCL_receptor | 4.086e-05 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | MDK_ligand | Neurons(Nos)_target | NCL_receptor | 3.449e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Neurons(Nos)_source | GRN_ligand | Epithelial,cells(Nos)_target | SORT1_receptor | 2.514e-04 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Neurons(Nos)_source | GRN_ligand | Erythrocytes(Nos)_target | SORT1_receptor | 3.000e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Epithelial,cells(Nos)_source | GRN_ligand | Neurons(Nos)_target | SORT1_receptor | 6.989e-04 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Erythrocytes(Nos)_source | GRN_ligand | Neurons(Nos)_target | SORT1_receptor | 2.094e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Neurons(Nos)_source | GRN_ligand | Neurons(Nos)_target | SORT1_receptor | 3.700e-04 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Neurons(Nos)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 2.274e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | ITGA6_ITGB1_receptor | 7.359e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Neurons(Nos)_target | ITGA6_ITGB1_receptor | 6.917e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 2.653e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 5.808e-07 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | SDC1_receptor | 3.743e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Epithelial,cells(Nos)_target | CD47_receptor | 3.524e-03 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Erythrocytes(Nos)_target | CD47_receptor | 1.307e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Neurons(Nos)_target | CD47_receptor | 1.108e-03 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | AGRN_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 3.101e-05 | 0.0 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | AGRN_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 7.627e-07 | 0.0 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | AGRN_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 8.649e-06 | 0.0 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | AGRN_ligand | Neurons(Nos)_target | DAG1_receptor | 1.145e-04 | 0.04 | AGRN | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | DAG1_receptor | 3.790e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 7.475e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Erythrocytes(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 1.749e-06 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Erythrocytes(Nos)_target | DAG1_receptor | 3.327e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | LAMC1_ligand | Neurons(Nos)_target | DAG1_receptor | 1.232e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Neurons(Nos)_source | CADM1_ligand | Neurons(Nos)_target | CADM1_receptor | 2.956e-05 | 0.0 | CADM | Cell-Cell Contact | PMID: 24503895 |
| Epithelial,cells(Nos)_source | CD226_ligand | Epithelial,cells(Nos)_target | NECTIN2_receptor | 2.858e-03 | 0.0 | CD226 | Cell-Cell Contact | PMID: 24440149 |
| Epithelial,cells(Nos)_source | CD226_ligand | Erythrocytes(Nos)_target | NECTIN2_receptor | 7.500e-05 | 0.0 | CD226 | Cell-Cell Contact | PMID: 24440149 |
| Epithelial,cells(Nos)_source | CD226_ligand | Neurons(Nos)_target | NECTIN2_receptor | 8.118e-04 | 0.0 | CD226 | Cell-Cell Contact | PMID: 24440149 |
| Epithelial,cells(Nos)_source | CD99_ligand | Epithelial,cells(Nos)_target | CD99_receptor | 5.040e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | CD99_ligand | Epithelial,cells(Nos)_target | CD99_receptor | 1.410e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CD99_ligand | Erythrocytes(Nos)_target | CD99_receptor | 1.410e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH2_ligand | Epithelial,cells(Nos)_target | CDH2_receptor | 1.151e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH2_ligand | Erythrocytes(Nos)_target | CDH2_receptor | 4.015e-05 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CDH2_ligand | Neurons(Nos)_target | CDH2_receptor | 1.151e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | CDH2_ligand | Neurons(Nos)_target | CDH2_receptor | 4.015e-05 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH2_ligand | Neurons(Nos)_target | CDH2_receptor | 6.278e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | EFNB2_ligand | Epithelial,cells(Nos)_target | EPHB2_receptor | 1.654e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB2_ligand | Erythrocytes(Nos)_target | EPHB2_receptor | 4.923e-08 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB2_ligand | Neurons(Nos)_target | EPHB2_receptor | 5.022e-07 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB3_ligand | Epithelial,cells(Nos)_target | EPHB2_receptor | 4.809e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB3_ligand | Erythrocytes(Nos)_target | EPHB2_receptor | 1.431e-07 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB3_ligand | Neurons(Nos)_target | EPHB2_receptor | 1.460e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Neurons(Nos)_source | L1CAM_ligand | Epithelial,cells(Nos)_target | L1CAM_receptor | 3.829e-08 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| Erythrocytes(Nos)_source | L1CAM_ligand | Erythrocytes(Nos)_target | L1CAM_receptor | 1.120e-10 | 0.02 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| Neurons(Nos)_source | L1CAM_ligand | Erythrocytes(Nos)_target | L1CAM_receptor | 1.192e-09 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| Epithelial,cells(Nos)_source | L1CAM_ligand | Neurons(Nos)_target | L1CAM_receptor | 3.829e-08 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| Erythrocytes(Nos)_source | L1CAM_ligand | Neurons(Nos)_target | L1CAM_receptor | 1.192e-09 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| Neurons(Nos)_source | L1CAM_ligand | Neurons(Nos)_target | L1CAM_receptor | 1.268e-08 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| Epithelial,cells(Nos)_source | NCAM1_ligand | Epithelial,cells(Nos)_target | NCAM1_receptor | 9.443e-03 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | NCAM1_ligand | Epithelial,cells(Nos)_target | L1CAM_receptor | 3.332e-05 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | NCAM1_ligand | Erythrocytes(Nos)_target | L1CAM_receptor | 1.037e-06 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | NCAM1_ligand | Neurons(Nos)_target | L1CAM_receptor | 1.104e-05 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | NECTIN3_ligand | Epithelial,cells(Nos)_target | NECTIN2_receptor | 4.410e-05 | 0.03 | NECTIN | Cell-Cell Contact | PMID: 23027581 |
| Erythrocytes(Nos)_source | NECTIN3_ligand | Erythrocytes(Nos)_target | NECTIN2_receptor | 1.157e-06 | 0.04 | NECTIN | Cell-Cell Contact | PMID: 23027581 |
| Erythrocytes(Nos)_source | NECTIN3_ligand | Neurons(Nos)_target | NECTIN2_receptor | 1.252e-05 | 0.03 | NECTIN | Cell-Cell Contact | PMID: 23027581 |
| Epithelial,cells(Nos)_source | NECTIN2_ligand | Epithelial,cells(Nos)_target | CD226_receptor | 2.858e-03 | 0.0 | NECTIN | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | NECTIN2_ligand | Epithelial,cells(Nos)_target | CD226_receptor | 7.500e-05 | 0.0 | NECTIN | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | NECTIN2_ligand | Epithelial,cells(Nos)_target | CD226_receptor | 8.118e-04 | 0.0 | NECTIN | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | OCLN_ligand | Epithelial,cells(Nos)_target | OCLN_receptor | 7.842e-10 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | OCLN_ligand | Epithelial,cells(Nos)_target | OCLN_receptor | 5.466e-09 | 0.01 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | OCLN_ligand | Erythrocytes(Nos)_target | OCLN_receptor | 7.842e-10 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | OCLN_ligand | Erythrocytes(Nos)_target | OCLN_receptor | 3.726e-11 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | OCLN_ligand | Erythrocytes(Nos)_target | OCLN_receptor | 2.597e-10 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | OCLN_ligand | Neurons(Nos)_target | OCLN_receptor | 5.466e-09 | 0.01 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Erythrocytes(Nos)_source | OCLN_ligand | Neurons(Nos)_target | OCLN_receptor | 2.597e-10 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | OCLN_ligand | Neurons(Nos)_target | OCLN_receptor | 1.810e-09 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | SEMA6A_ligand | Erythrocytes(Nos)_target | PLXNA2_receptor | 8.778e-06 | 0.01 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Epithelial,cells(Nos)_source | SEMA6A_ligand | Neurons(Nos)_target | PLXNA2_receptor | 1.330e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Erythrocytes(Nos)_source | SEMA6A_ligand | Neurons(Nos)_target | PLXNA2_receptor | 2.275e-06 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |