Sample overview

Project Name	TCGA-PRAD
GSE ID	GSE225021
GSM ID	GSM7037219
Cell Line	C4-2B
Tissue type	None
Disease Type	prostate cancer
PMID	\
Initial gene number	36601
Initial cell number	11242
Post-QC gene number	14123
Post-QC cell number	2334

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Erythrocytes(Nos)_source	IGF1_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	4.551e-06	0.0	IGF	Secreted Signaling	PMID: 28190785; PMID: 28873464
Epithelial,cells(Nos)_source	IGF1_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB4_receptor	4.445e-06	0.0	IGF	Secreted Signaling	PMID: 28190785; PMID: 28873464
Erythrocytes(Nos)_source	IGF1_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB4_receptor	3.248e-07	0.0	IGF	Secreted Signaling	PMID: 28190785; PMID: 28873464
Erythrocytes(Nos)_source	ANGPT2_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	4.200e-05	0.01	ANGPT	Secreted Signaling	PMID: 20651738; PMID: 25635707
Erythrocytes(Nos)_source	ANGPT2_ligand	Erythrocytes(Nos)_target	ITGA5_ITGB1_receptor	2.606e-06	0.0	ANGPT	Secreted Signaling	PMID: 20651738; PMID: 25635707
Epithelial,cells(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA1_ITGB1_receptor	2.123e-04	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA1_ITGB1_receptor	1.289e-05	0.04	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	2.444e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	1.485e-05	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB1_receptor	1.724e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB1_receptor	1.048e-05	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB4_receptor	4.820e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB4_receptor	2.930e-06	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	HSPG2_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	4.449e-05	0.04	HSPG	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	HSPG2_ligand	Erythrocytes(Nos)_target	DAG1_receptor	2.794e-06	0.03	HSPG	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	CADM1_ligand	Erythrocytes(Nos)_target	CADM1_receptor	8.554e-07	0.0	CADM	Cell-Cell Contact	PMID: 24503895
Erythrocytes(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	2.253e-04	0.01	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	2.253e-04	0.01	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	2.392e-05	0.01	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.588e-03	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	1.588e-03	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	8.971e-05	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	1.266e-03	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Erythrocytes(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	7.156e-05	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Erythrocytes(Nos)_source	F11R_ligand	Epithelial,cells(Nos)_target	F11R_receptor	1.804e-04	0.0	JAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	F11R_ligand	Erythrocytes(Nos)_target	F11R_receptor	1.804e-04	0.0	JAM	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	F11R_ligand	Erythrocytes(Nos)_target	F11R_receptor	2.458e-05	0.0	JAM	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	NRXN3_ligand	Erythrocytes(Nos)_target	NLGN1_receptor	1.346e-03	0.0	NRXN	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	NRXN3_ligand	Erythrocytes(Nos)_target	NLGN1_receptor	7.717e-05	0.03	NRXN	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	1.062e-04	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	OCLN_ligand	Erythrocytes(Nos)_target	OCLN_receptor	1.062e-04	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	OCLN_ligand	Erythrocytes(Nos)_target	OCLN_receptor	1.319e-05	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514