Sample overview

Project Name	TCGA-PRAD
GSE ID	GSE215943
GSM ID	GSM6647954
Cell Line	LNCaP
Tissue type	prostate
Disease Type	prostate adenocarcinoma
PMID	36382181
Initial gene number	36601
Initial cell number	6890
Post-QC gene number	12331
Post-QC cell number	3183

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	WNT4_ligand	Epithelial,cells(Nos)_target	FZD3_LRP5_receptor	6.748e-04	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	WNT7B_ligand	Epithelial,cells(Nos)_target	FZD3_LRP5_receptor	2.338e-03	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	WNT4_ligand	Epithelial,cells(Nos)_target	FZD3_LRP6_receptor	1.205e-03	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	WNT7B_ligand	Epithelial,cells(Nos)_target	FZD3_LRP6_receptor	4.171e-03	0.0	WNT	Secreted Signaling	KEGG: hsa04310; PMID: 23209147
Epithelial,cells(Nos)_source	COL6A1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.091e-02	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMA3_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	7.120e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMA3_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	9.128e-07	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA5_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	9.136e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.954e-02	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.983e-02	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	1.283e-01	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	2.076e-02	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	2.195e-02	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	DSC2_ligand	Epithelial,cells(Nos)_target	DSG2_receptor	3.851e-02	0.0	DESMOSOME	Cell-Cell Contact	PMID: 27298358
Epithelial,cells(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA3_receptor	2.389e-03	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA3_ligand	Epithelial,cells(Nos)_target	EPHA3_receptor	3.273e-03	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	EFNA5_ligand	Epithelial,cells(Nos)_target	EPHA3_receptor	3.446e-03	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	6.998e-03	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	JAG2_ligand	Erythrocytes(Nos)_target	NOTCH1_receptor	1.295e-06	0.02	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	3.515e-02	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	SEMA4A_ligand	Erythrocytes(Nos)_target	NRP1_PLXNA1_receptor	1.237e-05	0.03	SEMA4	Cell-Cell Contact	PMID: 27533782
Erythrocytes(Nos)_source	SEMA4A_ligand	Erythrocytes(Nos)_target	NRP1_PLXNA1_receptor	4.185e-08	0.04	SEMA4	Cell-Cell Contact	PMID: 27533782