Sample overview

Project Name	TCGA-PRAD
GSE ID	GSE215943
GSM ID	GSM6647952
Cell Line	LNCaP
Tissue type	prostate
Disease Type	prostate adenocarcinoma
PMID	36382181
Initial gene number	36601
Initial cell number	11427
Post-QC gene number	12022
Post-QC cell number	1610

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Nos)_target	TGFBR1_ACVR2A_receptor	3.086e-06	0.0	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Erythrocytes(Nos)_target	TGFBR1_ACVR2A_receptor	5.127e-06	0.0	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Nos)_target	TGFBR1_ACVR2B_receptor	4.484e-06	0.0	GDF	Secreted Signaling	KEGG: hsa04350
Erythrocytes(Nos)_source	GDF11_ligand	Epithelial,cells(Nos)_target	TGFBR1_ACVR2B_receptor	5.709e-06	0.01	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Erythrocytes(Nos)_target	TGFBR1_ACVR2B_receptor	5.911e-06	0.0	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Epithelial,cells(Nos)_target	ACVR1B_ACVR2B_receptor	4.754e-06	0.0	GDF	Secreted Signaling	KEGG: hsa04350
Epithelial,cells(Nos)_source	GDF11_ligand	Erythrocytes(Nos)_target	ACVR1B_ACVR2B_receptor	8.218e-06	0.0	GDF	Secreted Signaling	KEGG: hsa04350
Erythrocytes(Nos)_source	IGF1_ligand	Epithelial,cells(Nos)_target	IGF1R_receptor	1.908e-07	0.0	IGF	Secreted Signaling	PMID: 14604834
Erythrocytes(Nos)_source	IGF1_ligand	Erythrocytes(Nos)_target	IGF1R_receptor	3.058e-07	0.03	IGF	Secreted Signaling	PMID: 14604834
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	2.142e-05	0.01	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	8.605e-06	0.03	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Erythrocytes(Nos)_target	INSR_receptor	3.600e-05	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	NAMPT_ligand	Erythrocytes(Nos)_target	INSR_receptor	1.446e-05	0.04	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	2.164e-03	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	8.719e-04	0.01	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Erythrocytes(Nos)_target	ITGA5_ITGB1_receptor	3.723e-03	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	PSAP_ligand	Epithelial,cells(Nos)_target	GPR37_receptor	2.380e-06	0.0	PSAP	Secreted Signaling	PMID: 23690594
Erythrocytes(Nos)_source	PSAP_ligand	Epithelial,cells(Nos)_target	GPR37_receptor	3.610e-06	0.02	PSAP	Secreted Signaling	PMID: 23690594
HSC(Nos)_source	PSAP_ligand	Epithelial,cells(Nos)_target	GPR37_receptor	1.041e-06	0.0	PSAP	Secreted Signaling	PMID: 23690594
Epithelial,cells(Nos)_source	PSAP_ligand	Erythrocytes(Nos)_target	GPR37_receptor	3.814e-06	0.0	PSAP	Secreted Signaling	PMID: 23690594
HSC(Nos)_source	PSAP_ligand	Erythrocytes(Nos)_target	GPR37_receptor	1.668e-06	0.03	PSAP	Secreted Signaling	PMID: 23690594
Erythrocytes(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	1.179e-03	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	FN1_ligand	Erythrocytes(Nos)_target	ITGA5_ITGB1_receptor	2.025e-03	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	FN1_ligand	HSC(Nos)_target	ITGA5_ITGB1_receptor	4.330e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	8.167e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.133e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	1.383e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMB2_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	7.002e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.737e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	2.937e-03	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	6.077e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	3.077e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB1_receptor	1.058e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMB2_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB1_receptor	5.356e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	1.296e-03	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB1_receptor	2.256e-03	0.03	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	ITGAV_ITGB1_receptor	8.805e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	FN1_ligand	Erythrocytes(Nos)_target	ITGAV_ITGB1_receptor	1.658e-03	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	FN1_ligand	HSC(Nos)_target	ITGAV_ITGB1_receptor	3.159e-04	0.02	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Erythrocytes(Nos)_target	SDC1_receptor	1.673e-04	0.02	FN1	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	FN1_ligand	Erythrocytes(Nos)_target	SDC1_receptor	4.278e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	FN1_ligand	Erythrocytes(Nos)_target	SDC4_receptor	3.413e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	2.349e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMB2_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	1.190e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB2_ligand	Erythrocytes(Nos)_target	DAG1_receptor	4.197e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMB2_ligand	Erythrocytes(Nos)_target	DAG1_receptor	2.126e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	DAG1_receptor	5.030e-04	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Erythrocytes(Nos)_target	DAG1_receptor	8.988e-04	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	CD46_ligand	Erythrocytes(Nos)_target	JAG1_receptor	2.646e-04	0.0	CD46	Cell-Cell Contact	PMID: 23086448
HSC(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	8.838e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	8.838e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	2.349e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.518e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	2.562e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	2.562e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	2.710e-03	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Erythrocytes(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.578e-03	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	ITGA2_ITGB1_receptor	4.596e-03	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	DSC2_ligand	Epithelial,cells(Nos)_target	DSG2_receptor	1.969e-03	0.0	DESMOSOME	Cell-Cell Contact	PMID: 27298358
Erythrocytes(Nos)_source	DSC2_ligand	Epithelial,cells(Nos)_target	DSG2_receptor	2.732e-03	0.01	DESMOSOME	Cell-Cell Contact	PMID: 27298358
Epithelial,cells(Nos)_source	DSC2_ligand	Erythrocytes(Nos)_target	DSG2_receptor	3.116e-03	0.0	DESMOSOME	Cell-Cell Contact	PMID: 27298358
Epithelial,cells(Nos)_source	EFNB2_ligand	Erythrocytes(Nos)_target	EPHB4_receptor	1.682e-04	0.0	EPHB	Cell-Cell Contact	PMID: 15114347
Erythrocytes(Nos)_source	EFNB2_ligand	Erythrocytes(Nos)_target	EPHB4_receptor	2.553e-04	0.01	EPHB	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	4.612e-04	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	7.435e-04	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Erythrocytes(Nos)_target	MPZL1_receptor	7.435e-04	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	DLL3_ligand	Erythrocytes(Nos)_target	NOTCH1_receptor	1.581e-05	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Erythrocytes(Nos)_source	DLL3_ligand	Erythrocytes(Nos)_target	NOTCH2_receptor	7.011e-04	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
HSC(Nos)_source	DLL3_ligand	Erythrocytes(Nos)_target	NOTCH2_receptor	1.966e-04	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Erythrocytes(Nos)_source	JAG1_ligand	Erythrocytes(Nos)_target	NOTCH2_receptor	1.574e-04	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG2_ligand	Erythrocytes(Nos)_target	NOTCH2_receptor	1.171e-04	0.01	NOTCH	Cell-Cell Contact	PMID: 22353464
Erythrocytes(Nos)_source	JAG2_ligand	Erythrocytes(Nos)_target	NOTCH2_receptor	2.254e-04	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	2.038e-03	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	2.340e-03	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	5.854e-04	0.01	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	OCLN_ligand	Erythrocytes(Nos)_target	OCLN_receptor	2.340e-03	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	OCLN_ligand	HSC(Nos)_target	OCLN_receptor	5.854e-04	0.01	OCLN	Cell-Cell Contact	KEGG: hsa04514