Sample overview

Project Name	TCGA-PRAD
GSE ID	GSE206962
GSM ID	GSM6267382
Cell Line	None
Tissue type	prostate
Disease Type	prostate cancer
PMID	\
Initial gene number	33694
Initial cell number	4891
Post-QC gene number	4670
Post-QC cell number	1524

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Mesangial,cells(Nos)_source	WNT5A_ligand	Endothelial,cells(Nos)_target	FZD4_receptor	3.568e-05	0.0	ncWNT	Secreted Signaling	KEGG: hsa04310
Mesangial,cells(Nos)_source	WNT5A_ligand	Mesangial,cells(Nos)_target	FZD4_receptor	1.256e-04	0.0	ncWNT	Secreted Signaling	KEGG: hsa04310
Erythrocytes(Nos)_source	MIF_ligand	Epithelial,cells(Nos)_target	CD74_CD44_receptor	7.212e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Mesangial,cells(Nos)_source	MIF_ligand	Epithelial,cells(Nos)_target	CD74_CD44_receptor	9.607e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Endothelial,cells(Nos)_source	MIF_ligand	Macrophages(Nos)_target	CD74_CD44_receptor	1.500e-05	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Epithelial,cells(Nos)_source	MIF_ligand	Macrophages(Nos)_target	CD74_CD44_receptor	3.757e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Erythrocytes(Nos)_source	MIF_ligand	Macrophages(Nos)_target	CD74_CD44_receptor	3.311e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Macrophages(Nos)_source	MIF_ligand	Macrophages(Nos)_target	CD74_CD44_receptor	1.742e-05	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Mesangial,cells(Nos)_source	MIF_ligand	Macrophages(Nos)_target	CD74_CD44_receptor	4.411e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Epithelial,cells(Nos)_source	NAMPT_ligand	Endothelial,cells(Nos)_target	INSR_receptor	1.205e-04	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Erythrocytes(Nos)_source	NAMPT_ligand	Endothelial,cells(Nos)_target	INSR_receptor	8.143e-05	0.01	VISFATIN	Secreted Signaling	PMID: 28490838
Macrophages(Nos)_source	NAMPT_ligand	Endothelial,cells(Nos)_target	INSR_receptor	1.436e-05	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Mesangial,cells(Nos)_source	NAMPT_ligand	Endothelial,cells(Nos)_target	INSR_receptor	1.299e-04	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	1.022e-03	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Erythrocytes(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	6.906e-04	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Macrophages(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	1.222e-04	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Mesangial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	INSR_receptor	1.103e-03	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Erythrocytes(Nos)_source	MDK_ligand	Erythrocytes(Nos)_target	SDC2_receptor	1.813e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Erythrocytes(Nos)_target	SDC2_receptor	2.278e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	SDC2_receptor	4.876e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	SDC2_receptor	4.888e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	SDC2_receptor	6.153e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.161e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.187e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.748e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Macrophages(Nos)_target	SDC4_receptor	2.321e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Macrophages(Nos)_target	SDC4_receptor	2.917e-04	0.01	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Endothelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.203e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Endothelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.215e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Endothelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.786e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Erythrocytes(Nos)_target	ITGA6_ITGB1_receptor	5.514e-04	0.01	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	ITGA6_ITGB1_receptor	1.178e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	ITGA6_ITGB1_receptor	1.196e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	ITGA6_ITGB1_receptor	1.501e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Endothelial,cells(Nos)_target	NCL_receptor	2.555e-04	0.04	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Endothelial,cells(Nos)_target	NCL_receptor	2.564e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Endothelial,cells(Nos)_target	NCL_receptor	3.227e-04	0.0	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	NCL_receptor	2.865e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Mesangial,cells(Nos)_source	MDK_ligand	Mesangial,cells(Nos)_target	NCL_receptor	3.601e-03	0.01	MK	Secreted Signaling	PMID: 28356350
Erythrocytes(Nos)_source	PTN_ligand	Epithelial,cells(Nos)_target	SDC2_receptor	1.443e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Erythrocytes(Nos)_target	SDC2_receptor	1.759e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Mesangial,cells(Nos)_target	SDC2_receptor	4.873e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Epithelial,cells(Nos)_target	SDC4_receptor	2.115e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Macrophages(Nos)_target	SDC4_receptor	2.251e-05	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Mesangial,cells(Nos)_target	SDC4_receptor	1.136e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Endothelial,cells(Nos)_target	NCL_receptor	2.547e-05	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Epithelial,cells(Nos)_target	NCL_receptor	1.385e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Erythrocytes(Nos)_target	NCL_receptor	1.891e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Macrophages(Nos)_target	NCL_receptor	1.286e-05	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Erythrocytes(Nos)_source	PTN_ligand	Mesangial,cells(Nos)_target	NCL_receptor	2.794e-04	0.0	PTN	Secreted Signaling	PMID: 28356350; PMID: 25620911
Endothelial,cells(Nos)_source	APP_ligand	Endothelial,cells(Nos)_target	CD74_receptor	1.848e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	Endothelial,cells(Nos)_target	CD74_receptor	1.097e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Erythrocytes(Nos)_source	APP_ligand	Endothelial,cells(Nos)_target	CD74_receptor	1.829e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Mesangial,cells(Nos)_source	APP_ligand	Endothelial,cells(Nos)_target	CD74_receptor	2.708e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Endothelial,cells(Nos)_source	APP_ligand	Epithelial,cells(Nos)_target	CD74_receptor	2.049e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
Erythrocytes(Nos)_source	APP_ligand	Epithelial,cells(Nos)_target	CD74_receptor	2.001e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Mesangial,cells(Nos)_source	APP_ligand	Epithelial,cells(Nos)_target	CD74_receptor	2.975e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Endothelial,cells(Nos)_source	APP_ligand	Macrophages(Nos)_target	CD74_receptor	3.079e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	Macrophages(Nos)_target	CD74_receptor	1.823e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Erythrocytes(Nos)_source	APP_ligand	Macrophages(Nos)_target	CD74_receptor	3.044e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Mesangial,cells(Nos)_source	APP_ligand	Macrophages(Nos)_target	CD74_receptor	4.510e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	CD46_ligand	Endothelial,cells(Nos)_target	JAG1_receptor	1.073e-08	0.01	CD46	Cell-Cell Contact	PMID: 23086448
Erythrocytes(Nos)_source	CD46_ligand	Endothelial,cells(Nos)_target	JAG1_receptor	9.197e-09	0.01	CD46	Cell-Cell Contact	PMID: 23086448
Mesangial,cells(Nos)_source	CD46_ligand	Endothelial,cells(Nos)_target	JAG1_receptor	9.712e-09	0.02	CD46	Cell-Cell Contact	PMID: 23086448
Erythrocytes(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	1.153e-07	0.03	CD46	Cell-Cell Contact	PMID: 23086448
Erythrocytes(Nos)_source	CD46_ligand	Erythrocytes(Nos)_target	JAG1_receptor	8.936e-08	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Erythrocytes(Nos)_source	CD46_ligand	Mesangial,cells(Nos)_target	JAG1_receptor	1.254e-07	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Endothelial,cells(Nos)_source	CD99_ligand	Endothelial,cells(Nos)_target	CD99_receptor	4.892e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CD99_ligand	Endothelial,cells(Nos)_target	CD99_receptor	4.489e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Endothelial,cells(Nos)_target	CD99_receptor	4.024e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Macrophages(Nos)_source	CD99_ligand	Endothelial,cells(Nos)_target	CD99_receptor	4.585e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CD99_ligand	Endothelial,cells(Nos)_target	CD99_receptor	4.977e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CD99_ligand	Epithelial,cells(Nos)_target	CD99_receptor	4.489e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	4.024e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	3.234e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	3.990e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CD99_ligand	Macrophages(Nos)_target	CD99_receptor	4.585e-05	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Endothelial,cells(Nos)_source	CD99_ligand	Mesangial,cells(Nos)_target	CD99_receptor	4.977e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	Mesangial,cells(Nos)_target	CD99_receptor	3.990e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	CDH1_ligand	Mesangial,cells(Nos)_target	CDH1_receptor	5.265e-05	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Mesangial,cells(Nos)_source	DSC2_ligand	Mesangial,cells(Nos)_target	DSG2_receptor	1.119e-04	0.0	DESMOSOME	Cell-Cell Contact	PMID: 27298358
Mesangial,cells(Nos)_source	OCLN_ligand	Mesangial,cells(Nos)_target	OCLN_receptor	8.861e-10	0.01	OCLN	Cell-Cell Contact	KEGG: hsa04514