Sample overview

Project Name	TCGA-PRAD
GSE ID	GSE205765
GSM ID	GSM6225771
Cell Line	LNCaP
Tissue type	prostate
Disease Type	prostate cancer
PMID	35905714
Initial gene number	33538
Initial cell number	10119
Post-QC gene number	9696
Post-QC cell number	1124

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Erythrocytes(Nos)_source	NAMPT_ligand	Keratinocytes(Nos)_target	INSR_receptor	3.608e-05	0.01	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	NAMPT_ligand	Keratinocytes(Nos)_target	INSR_receptor	2.450e-05	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Keratinocytes(Nos)_source	NAMPT_ligand	Keratinocytes(Nos)_target	INSR_receptor	6.568e-06	0.01	VISFATIN	Secreted Signaling	PMID: 28490838
HSC(Nos)_source	LAMC1_ligand	HSC(Nos)_target	ITGA6_ITGB1_receptor	9.681e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Keratinocytes(Nos)_source	LAMC1_ligand	HSC(Nos)_target	ITGA6_ITGB1_receptor	4.338e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Erythrocytes(Nos)_source	LAMC1_ligand	Keratinocytes(Nos)_target	ITGA6_ITGB1_receptor	6.958e-05	0.04	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMC1_ligand	Keratinocytes(Nos)_target	ITGA6_ITGB1_receptor	4.562e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Keratinocytes(Nos)_source	LAMC1_ligand	Keratinocytes(Nos)_target	ITGA6_ITGB1_receptor	2.044e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	FN1_ligand	HSC(Nos)_target	ITGAV_ITGB1_receptor	2.731e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Keratinocytes(Nos)_source	FN1_ligand	HSC(Nos)_target	ITGAV_ITGB1_receptor	1.665e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	FN1_ligand	Keratinocytes(Nos)_target	ITGAV_ITGB1_receptor	1.216e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Keratinocytes(Nos)_source	FN1_ligand	Keratinocytes(Nos)_target	ITGAV_ITGB1_receptor	7.415e-05	0.0	FN1	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMC1_ligand	HSC(Nos)_target	DAG1_receptor	4.077e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Keratinocytes(Nos)_source	LAMC1_ligand	HSC(Nos)_target	DAG1_receptor	1.827e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	LAMC1_ligand	Keratinocytes(Nos)_target	DAG1_receptor	2.095e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Keratinocytes(Nos)_source	LAMC1_ligand	Keratinocytes(Nos)_target	DAG1_receptor	9.388e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
HSC(Nos)_source	CD99_ligand	Erythrocytes(Nos)_target	CD99_receptor	7.531e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	7.531e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	4.897e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
Keratinocytes(Nos)_source	CD99_ligand	HSC(Nos)_target	CD99_receptor	1.475e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CD99_ligand	Keratinocytes(Nos)_target	CD99_receptor	1.475e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	Erythrocytes(Nos)_target	CDH1_receptor	1.886e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	1.886e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	2.533e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Keratinocytes(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	4.654e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	Keratinocytes(Nos)_target	CDH1_receptor	4.654e-05	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	MPZL1_ligand	Erythrocytes(Nos)_target	MPZL1_receptor	6.672e-05	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	MPZL1_ligand	HSC(Nos)_target	MPZL1_receptor	6.672e-05	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	MPZL1_ligand	HSC(Nos)_target	MPZL1_receptor	4.432e-05	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
Keratinocytes(Nos)_source	MPZL1_ligand	HSC(Nos)_target	MPZL1_receptor	2.111e-05	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	MPZL1_ligand	Keratinocytes(Nos)_target	MPZL1_receptor	2.111e-05	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
Keratinocytes(Nos)_source	MPZL1_ligand	Keratinocytes(Nos)_target	MPZL1_receptor	1.005e-05	0.01	MPZ	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	OCLN_ligand	Erythrocytes(Nos)_target	OCLN_receptor	2.512e-07	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Erythrocytes(Nos)_source	OCLN_ligand	HSC(Nos)_target	OCLN_receptor	2.512e-07	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	OCLN_ligand	HSC(Nos)_target	OCLN_receptor	2.175e-05	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Keratinocytes(Nos)_source	OCLN_ligand	HSC(Nos)_target	OCLN_receptor	4.981e-08	0.03	OCLN	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	OCLN_ligand	Keratinocytes(Nos)_target	OCLN_receptor	4.981e-08	0.03	OCLN	Cell-Cell Contact	KEGG: hsa04514