Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5828146
Cell Line	None
Tissue type	High Grade Serous Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	33562
Initial cell number	14969
Post-QC gene number	8697
Post-QC cell number	5611

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Nos)_source	CCL4_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	5.263e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	8.405e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL3_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	3.864e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Good)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	3.859e-04	0.01	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	2.711e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	2.730e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CD44_receptor	2.389e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	2.681e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	1.018e-03	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	4.499e-03	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	4.250e-03	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF14_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	3.666e-03	0.0	LIGHT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CD70_ligand	CD8+,T-cells(Nos)_target	CD27_receptor	8.610e-03	0.0	CD70	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Good)_source	GZMA_ligand	CD8+,T-cells(Nos)_target	F2R_receptor	1.645e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD8+,T-cells(Nos)_source	GZMA_ligand	CD8+,T-cells(Nos)_target	F2R_receptor	1.702e-02	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Good)_target	PTPRC_receptor	1.053e-04	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	PTPRC_receptor	1.237e-03	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Poor)_target	PTPRC_receptor	6.010e-05	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Good)_target	HAVCR2_receptor	1.707e-05	0.0	GALECTIN	Secreted Signaling	PMID: 27192565
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	HAVCR2_receptor	4.088e-04	0.0	GALECTIN	Secreted Signaling	PMID: 27192565
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Poor)_target	HAVCR2_receptor	1.042e-05	0.0	GALECTIN	Secreted Signaling	PMID: 27192565
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Good)_target	CD44_receptor	2.253e-05	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	2.528e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
CD8+,T-cells(Good)_source	LGALS9_ligand	CD8+,T-cells(Poor)_target	CD44_receptor	5.397e-06	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
CD8+,T-cells(Good)_source	CD99_ligand	CD8+,T-cells(Good)_target	CD99_receptor	1.184e-03	0.03	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Good)_target	CD99_receptor	1.226e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.226e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAX_ITGB2_receptor	6.834e-03	0.0	ICAM	Cell-Cell Contact	PMID: 16252253
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	5.612e-03	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_receptor	2.573e-03	0.0	ICAM	Cell-Cell Contact	PMID: 23602662
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	SPN_receptor	1.567e-03	0.0	ICAM	Cell-Cell Contact	PMID: 1683685
CD8+,T-cells(Nos)_source	ITGB2_ligand	CD8+,T-cells(Nos)_target	ICAM1_receptor	1.218e-02	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	LCK_ligand	CD8+,T-cells(Nos)_target	CD8 receptor_receptor	6.568e-02	0.0	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	1.170e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.232e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.274e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	1.254e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.321e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.371e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	1.213e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.277e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.322e-01	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.560e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	7.478e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	7.871e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	1.222e-03	0.03	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.291e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.336e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	1.309e-03	0.04	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.383e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.436e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	1.266e-03	0.04	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.338e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.385e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.546e-02	0.04	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.632e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	7.840e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	8.281e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514