Sample overview
| Project Name | TCGA-OV |
| GSE ID | GSE195486 |
| GSM ID | GSM5828145 |
| Cell Line | None |
| Tissue type | High Grade Serous Ovarian Cancer tumor tissue |
| Disease Type | High Grade Serous Ovarian Cancer tumor |
| PMID | 35427494 |
| Initial gene number | 33694 |
| Initial cell number | 12510 |
| Post-QC gene number | 8707 |
| Post-QC cell number | 8334 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| NK,cells(Nos)_source | TGFB1_ligand | CD8+,T-cells(Nos)_target | TGFbR1_R2_receptor | 2.475e-04 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| CD8+,T-cells(Nos)_source | TGFB1_ligand | NK,cells(Nos)_target | TGFbR1_R2_receptor | 1.389e-04 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| NK,cells(Nos)_source | TGFB1_ligand | NK,cells(Nos)_target | TGFbR1_R2_receptor | 6.202e-05 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| NK,cells(Nos)_source | CCL5_ligand | CD8+,T-cells(Nos)_target | CCR1_receptor | 1.943e-02 | 0.0 | CCL | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | CCL5_ligand | NK,cells(Nos)_target | CCR1_receptor | 1.958e-02 | 0.0 | CCL | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | CCL5_ligand | NK,cells(Nos)_target | CCR1_receptor | 4.201e-03 | 0.0 | CCL | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | CCL3_ligand | CD8+,T-cells(Nos)_target | CCR1_receptor | 6.549e-03 | 0.0 | CCL | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | CCL3_ligand | NK,cells(Nos)_target | CCR1_receptor | 1.427e-03 | 0.0 | CCL | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | CXCL13_ligand | CD8+,T-cells(Nos)_target | CXCR3_receptor | 7.289e-03 | 0.0 | CXCL | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | CXCL13_ligand | NK,cells(Nos)_target | CXCR3_receptor | 1.633e-03 | 0.0 | CXCL | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 5.081e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 6.937e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CD44_receptor | 6.610e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CD44_receptor | 1.472e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | LTA_ligand | CD8+,T-cells(Nos)_target | TNFRSF1A_receptor | 3.898e-04 | 0.0 | LT | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | LTA_ligand | NK,cells(Nos)_target | TNFRSF1A_receptor | 3.692e-04 | 0.01 | LT | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | LTA_ligand | NK,cells(Nos)_target | TNFRSF1A_receptor | 8.419e-05 | 0.0 | LT | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | LTA_ligand | NK,cells(Nos)_target | TNFRSF1B_receptor | 1.005e-03 | 0.0 | LT | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | LTA_ligand | NK,cells(Nos)_target | TNFRSF1B_receptor | 2.290e-04 | 0.0 | LT | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | LTA_ligand | CD8+,T-cells(Nos)_target | TNFRSF14_receptor | 5.988e-04 | 0.0 | LT | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | LTA_ligand | NK,cells(Nos)_target | TNFRSF14_receptor | 1.123e-04 | 0.04 | LT | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | TNFSF14_ligand | CD8+,T-cells(Nos)_target | TNFRSF14_receptor | 4.830e-04 | 0.0 | LIGHT | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | FASLG_ligand | CD8+,T-cells(Nos)_target | FAS_receptor | 1.124e-04 | 0.0 | FASLG | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | FASLG_ligand | NK,cells(Nos)_target | FAS_receptor | 6.050e-05 | 0.01 | FASLG | Secreted Signaling | KEGG: hsa04060 |
| NK,cells(Nos)_source | FASLG_ligand | NK,cells(Nos)_target | FAS_receptor | 2.723e-05 | 0.0 | FASLG | Secreted Signaling | KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source | GZMA_ligand | CD8+,T-cells(Nos)_target | F2R_receptor | 1.075e-02 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| NK,cells(Nos)_source | GZMA_ligand | CD8+,T-cells(Nos)_target | F2R_receptor | 2.317e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| CD8+,T-cells(Nos)_source | BTLA_ligand | CD8+,T-cells(Nos)_target | TNFRSF14_receptor | 9.478e-04 | 0.0 | BTLA | Secreted Signaling | PMID: 21941365 |
| NK,cells(Nos)_source | BAG6_ligand | CD8+,T-cells(Nos)_target | NCR3_receptor | 1.155e-04 | 0.0 | BAG | Secreted Signaling | PMID: 30021652 |
| CD8+,T-cells(Nos)_source | BAG6_ligand | NK,cells(Nos)_target | NCR3_receptor | 4.546e-06 | 0.0 | BAG | Secreted Signaling | PMID: 30021652 |
| NK,cells(Nos)_source | BAG6_ligand | NK,cells(Nos)_target | NCR3_receptor | 1.031e-04 | 0.0 | BAG | Secreted Signaling | PMID: 30021652 |
| NK,cells(Nos)_source | CD48_ligand | CD8+,T-cells(Nos)_target | CD244_receptor | 1.234e-05 | 0.0 | CD48 | Cell-Cell Contact | PMID: 26697006 |
| CD8+,T-cells(Nos)_source | CD48_ligand | NK,cells(Nos)_target | CD244_receptor | 9.320e-04 | 0.0 | CD48 | Cell-Cell Contact | PMID: 26697006 |
| NK,cells(Nos)_source | CD48_ligand | NK,cells(Nos)_target | CD244_receptor | 2.419e-04 | 0.0 | CD48 | Cell-Cell Contact | PMID: 26697006 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 1.243e-01 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CLEC2D_ligand | NK,cells(Nos)_target | KLRB1_receptor | 8.133e-04 | 0.04 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 3.059e-03 | 0.01 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 6.783e-04 | 0.01 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 3.755e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 8.324e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | ICAM1_ligand | CD8+,T-cells(Nos)_target | ITGAX_ITGB2_receptor | 1.056e-03 | 0.0 | ICAM | Cell-Cell Contact | PMID: 16252253 |
| CD8+,T-cells(Nos)_source | ICAM1_ligand | NK,cells(Nos)_target | ITGAX_ITGB2_receptor | 1.046e-03 | 0.0 | ICAM | Cell-Cell Contact | PMID: 16252253 |
| NK,cells(Nos)_source | ICAM1_ligand | NK,cells(Nos)_target | ITGAX_ITGB2_receptor | 2.252e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 16252253 |
| NK,cells(Nos)_source | ICAM1_ligand | CD8+,T-cells(Nos)_target | ITGAL_ITGB2_receptor | 8.745e-04 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | ICAM1_ligand | NK,cells(Nos)_target | ITGAL_ITGB2_receptor | 8.888e-04 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | ICAM1_ligand | NK,cells(Nos)_target | ITGAL_ITGB2_receptor | 1.914e-04 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | ICAM1_ligand | CD8+,T-cells(Nos)_target | SPN_receptor | 2.650e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 1683685 |
| NK,cells(Nos)_source | ICAM1_ligand | NK,cells(Nos)_target | SPN_receptor | 5.327e-05 | 0.0 | ICAM | Cell-Cell Contact | PMID: 1683685 |
| CD8+,T-cells(Nos)_source | ITGB2_ligand | NK,cells(Nos)_target | ICAM1_receptor | 1.939e-03 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | ITGB2_ligand | NK,cells(Nos)_target | ICAM1_receptor | 3.842e-04 | 0.04 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | L1CAM_ligand | NK,cells(Nos)_target | ITGA4_ITGB7_receptor | 5.876e-06 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 8557754 |
| NK,cells(Nos)_source | L1CAM_ligand | NK,cells(Nos)_target | ITGA4_ITGB7_receptor | 1.256e-06 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 8557754 |
| NK,cells(Nos)_source | L1CAM_ligand | CD8+,T-cells(Nos)_target | L1CAM_receptor | 2.978e-08 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| CD8+,T-cells(Nos)_source | L1CAM_ligand | NK,cells(Nos)_target | L1CAM_receptor | 2.978e-08 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| NK,cells(Nos)_source | L1CAM_ligand | NK,cells(Nos)_target | L1CAM_receptor | 6.368e-09 | 0.0 | L1CAM | Cell-Cell Contact | PMID: 18701456 |
| CD8+,T-cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 9.502e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.872e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.012e-01 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 2.014e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 9.025e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.839e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 1.213e-01 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8A_receptor | 2.397e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.139e-01 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-A_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 2.247e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.211e-01 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-B_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 2.411e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.084e-01 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 2.208e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 1.442e-01 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-E_ligand | CD8+,T-cells(Nos)_target | CD8B_receptor | 2.852e-02 | 0.0 | MHC-I | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | HLA-C_ligand | CD8+,T-cells(Nos)_target | KIR2DL3_receptor | 1.233e-02 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| CD8+,T-cells(Nos)_source | HLA-C_ligand | NK,cells(Nos)_target | KIR2DL3_receptor | 1.272e-02 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| NK,cells(Nos)_source | HLA-C_ligand | NK,cells(Nos)_target | KIR2DL3_receptor | 2.593e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| CD8+,T-cells(Nos)_source | HLA-B_ligand | NK,cells(Nos)_target | KIR3DL2_receptor | 3.600e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| NK,cells(Nos)_source | HLA-B_ligand | NK,cells(Nos)_target | KIR3DL2_receptor | 7.154e-04 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | KLRC1_receptor | 1.126e-02 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | KLRC1_receptor | 2.222e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | KLRC2_receptor | 4.061e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 26697006 |
| NK,cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | KLRC2_receptor | 8.002e-04 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 26697006 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | KLRK1_receptor | 3.444e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | CD94:NKG2A_receptor | 1.452e-02 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| NK,cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | CD94:NKG2A_receptor | 2.865e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | CD94:NKG2C_receptor | 8.864e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| NK,cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | CD94:NKG2C_receptor | 1.748e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| CD8+,T-cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | CD94:NKG2E_receptor | 1.777e-02 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| NK,cells(Nos)_source | HLA-E_ligand | NK,cells(Nos)_target | CD94:NKG2E_receptor | 3.509e-03 | 0.0 | MHC-I | Cell-Cell Contact | PMID: 28484462 |
| NK,cells(Nos)_source | PECAM1_ligand | CD8+,T-cells(Nos)_target | PECAM1_receptor | 5.195e-04 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | PECAM1_ligand | NK,cells(Nos)_target | PECAM1_receptor | 5.195e-04 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | PECAM1_ligand | NK,cells(Nos)_target | PECAM1_receptor | 1.225e-04 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |