Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5828144
Cell Line	None
Tissue type	High Grade Serous Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	33694
Initial cell number	8613
Post-QC gene number	6493
Post-QC cell number	5143

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
NK,cells(Nos)_source	CCL4_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	5.451e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL4_ligand	NK,cells(Nos)_target	CCR5_receptor	4.968e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL4_ligand	NK,cells(Nos)_target	CCR5_receptor	6.773e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	6.909e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR5_receptor	6.945e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR5_receptor	8.574e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	1.137e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL3_ligand	NK,cells(Nos)_target	CCR5_receptor	7.937e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3_ligand	NK,cells(Nos)_target	CCR5_receptor	1.418e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	CXCL13_ligand	CD4+,T-cells(Nos)_target	CXCR3_receptor	2.397e-05	0.0	CXCL	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	CXCL13_ligand	CD8+,T-cells(Nos)_target	CXCR3_receptor	9.419e-04	0.0	CXCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CXCL13_ligand	CD8+,T-cells(Nos)_target	CXCR3_receptor	3.296e-03	0.0	CXCL	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	CXCL13_ligand	NK,cells(Nos)_target	CXCR3_receptor	6.455e-05	0.0	CXCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	6.249e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	5.015e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD4+,T-cells(Nos)_source	IL2_ligand	CD4+,T-cells(Nos)_target	IL2RB_IL2RG_receptor	5.803e-06	0.0	IL2	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	IL2_ligand	CD8+,T-cells(Nos)_target	IL2RB_IL2RG_receptor	2.248e-04	0.0	IL2	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	IL2_ligand	NK,cells(Nos)_target	IL2RB_IL2RG_receptor	2.592e-05	0.0	IL2	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	6.336e-04	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	NK,cells(Nos)_target	TNFRSF1B_receptor	2.743e-06	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	NK,cells(Nos)_target	TNFRSF1B_receptor	9.141e-05	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	CD4+,T-cells(Nos)_target	TNFRSF14_receptor	9.013e-07	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD4+,T-cells(Nos)_target	TNFRSF14_receptor	3.004e-05	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	7.684e-04	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	3.059e-06	0.04	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	1.020e-04	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	BTLA_ligand	CD4+,T-cells(Nos)_target	TNFRSF14_receptor	2.285e-06	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	BTLA_ligand	CD4+,T-cells(Nos)_target	TNFRSF14_receptor	2.334e-05	0.01	BTLA	Secreted Signaling	PMID: 21941365
NK,cells(Nos)_source	BTLA_ligand	CD4+,T-cells(Nos)_target	TNFRSF14_receptor	2.803e-06	0.01	BTLA	Secreted Signaling	PMID: 21941365
CD4+,T-cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	5.850e-05	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD4+,T-cells(Nos)_source	BTLA_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	7.761e-06	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	BTLA_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	7.921e-05	0.01	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	ADGRE5_ligand	NK,cells(Nos)_target	CD55_receptor	9.104e-04	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
NK,cells(Nos)_source	ADGRE5_ligand	NK,cells(Nos)_target	CD55_receptor	1.184e-04	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
NK,cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.752e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	1.752e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	2.174e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CLEC2D_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	2.496e-05	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	CLEC2D_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	3.574e-04	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	CLEC2D_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	3.823e-05	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	CLEC2B_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	1.168e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	CLEC2B_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	1.240e-04	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD4+,T-cells(Nos)_source	CD69_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	5.706e-05	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	CD69_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	2.356e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	CD69_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	2.585e-04	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD4+,T-cells(Nos)_source	ITGB2_ligand	CD4+,T-cells(Nos)_target	CD226_receptor	6.638e-06	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGB2_ligand	CD4+,T-cells(Nos)_target	CD226_receptor	2.182e-04	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	ITGB2_ligand	CD4+,T-cells(Nos)_target	CD226_receptor	3.873e-05	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	LCK_ligand	CD8+,T-cells(Nos)_target	CD8 receptor_receptor	4.777e-02	0.0	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.158e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.224e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.415e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.103e-01	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.347e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	1.519e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.347e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.590e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.376e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.452e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.678e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.313e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.600e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.592e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.878e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	KIR2DL3_receptor	9.484e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD4+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	KIR2DL3_receptor	2.771e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	KIR2DL3_receptor	1.088e-02	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	KIR2DL3_receptor	1.329e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD4+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRC1_receptor	1.971e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRC1_receptor	7.965e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRC1_receptor	9.418e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 24223577
CD4+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRK1_receptor	4.034e-05	0.01	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRK1_receptor	1.639e-03	0.01	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRK1_receptor	1.942e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD4+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	2.688e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	1.084e-02	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	1.280e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD4+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	1.819e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	7.352e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	8.695e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD4+,T-cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	1.764e-05	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607
CD8+,T-cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	7.546e-04	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607
NK,cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	9.573e-05	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607
NK,cells(Nos)_source	SELPLG_ligand	CD8+,T-cells(Nos)_target	SELL_receptor	8.306e-04	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607