Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5798835
Cell Line	None
Tissue type	High Grade Serous Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	33562
Initial cell number	9000
Post-QC gene number	6978
Post-QC cell number	5411

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
NK,cells(Nos)_source	CCL4_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	4.520e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL4_ligand	NK,cells(Nos)_target	CCR5_receptor	4.139e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL4_ligand	NK,cells(Nos)_target	CCR5_receptor	3.773e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	5.680e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR5_receptor	5.782e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR5_receptor	4.733e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CXCL13_ligand	CD8+,T-cells(Nos)_target	CXCR3_receptor	4.136e-03	0.0	CXCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	7.528e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
Epithelial,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	5.091e-04	0.01	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	5.101e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Epithelial,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	3.468e-04	0.01	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	IL2_ligand	NK,cells(Nos)_target	IL2RB_IL2RG_receptor	7.735e-05	0.0	IL2	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	IL2_ligand	NK,cells(Nos)_target	IL2RB_IL2RG_receptor	6.340e-06	0.01	IL2	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	8.942e-06	0.0	TNF	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNF_ligand	Epithelial,cells(Nos)_target	TNFRSF1A_receptor	1.603e-06	0.0	TNF	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNF_ligand	NK,cells(Nos)_target	TNFRSF1A_receptor	4.048e-07	0.01	TNF	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	2.086e-04	0.0	TNF	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNF_ligand	NK,cells(Nos)_target	TNFRSF1B_receptor	5.020e-05	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF10_ligand	CD8+,T-cells(Nos)_target	TNFRSF10A_receptor	1.189e-05	0.0	TRAIL	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	TNFSF10_ligand	CD8+,T-cells(Nos)_target	TNFRSF10A_receptor	7.739e-07	0.0	TRAIL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF10_ligand	Epithelial,cells(Nos)_target	TNFRSF10A_receptor	1.219e-07	0.02	TRAIL	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	TNFSF10_ligand	Epithelial,cells(Nos)_target	TNFRSF10A_receptor	7.931e-09	0.04	TRAIL	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	NAMPT_ligand	CD8+,T-cells(Nos)_target	ITGA5_ITGB1_receptor	2.261e-05	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	1.801e-07	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	NK,cells(Nos)_target	ITGA5_ITGB1_receptor	5.199e-06	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	PTPRC_receptor	2.205e-04	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Epithelial,cells(Nos)_source	LGALS9_ligand	Epithelial,cells(Nos)_target	PTPRC_receptor	1.015e-07	0.01	GALECTIN	Secreted Signaling	PMID: 30120235
Epithelial,cells(Nos)_source	LGALS9_ligand	NK,cells(Nos)_target	PTPRC_receptor	1.817e-05	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
NK,cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.330e-04	0.0	BTLA	Secreted Signaling	PMID: 21941365
NK,cells(Nos)_source	BTLA_ligand	Epithelial,cells(Nos)_target	TNFRSF14_receptor	6.991e-07	0.03	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	BTLA_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	9.585e-05	0.0	BTLA	Secreted Signaling	PMID: 21941365
NK,cells(Nos)_source	BTLA_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	1.765e-05	0.0	BTLA	Secreted Signaling	PMID: 21941365
Epithelial,cells(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	7.175e-05	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	LGALS9_ligand	Epithelial,cells(Nos)_target	CD44_receptor	8.108e-08	0.01	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	LGALS9_ligand	NK,cells(Nos)_target	CD44_receptor	4.335e-06	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
CD8+,T-cells(Nos)_source	ADGRE5_ligand	Epithelial,cells(Nos)_target	CD55_receptor	9.488e-05	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
NK,cells(Nos)_source	ADGRE5_ligand	Epithelial,cells(Nos)_target	CD55_receptor	8.146e-06	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
CD8+,T-cells(Nos)_source	ADGRE5_ligand	NK,cells(Nos)_target	CD55_receptor	7.257e-04	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
NK,cells(Nos)_source	ADGRE5_ligand	NK,cells(Nos)_target	CD55_receptor	6.236e-05	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
Epithelial,cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	3.768e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
NK,cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	1.184e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	Epithelial,cells(Nos)_target	CD74_receptor	1.306e-06	0.0	APP	Cell-Cell Contact	PMID: 19849849
NK,cells(Nos)_source	APP_ligand	Epithelial,cells(Nos)_target	CD74_receptor	3.974e-07	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	2.157e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
NK,cells(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	6.642e-06	0.0	APP	Cell-Cell Contact	PMID: 19849849
NK,cells(Nos)_source	CD48_ligand	CD8+,T-cells(Nos)_target	CD244_receptor	2.507e-06	0.0	CD48	Cell-Cell Contact	PMID: 26697006
NK,cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.290e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	1.290e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	1.159e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.560e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.230e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	9.287e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.490e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8A_receptor	1.126e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	1.381e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	1.036e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.310e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	1.361e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	1.087e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.582e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	1.601e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	1.307e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRC1_receptor	7.293e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRC1_receptor	6.024e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	9.849e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	8.108e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462