Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5798834
Cell Line	None
Tissue type	High Grade Serous Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	33562
Initial cell number	10000
Post-QC gene number	8168
Post-QC cell number	6871

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
NK,cells(Nos)_source	CCL4_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	2.274e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL4_ligand	NK,cells(Nos)_target	CCR5_receptor	2.198e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL4_ligand	NK,cells(Nos)_target	CCR5_receptor	1.060e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	3.158e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR5_receptor	3.078e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR5_receptor	1.469e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	5.839e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL3_ligand	NK,cells(Nos)_target	CCR5_receptor	3.741e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3_ligand	NK,cells(Nos)_target	CCR5_receptor	2.733e-05	0.0	CCL	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	6.757e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
NK,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	3.307e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
Epithelial,cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CXCR4_receptor	2.934e-05	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
NK,cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CXCR4_receptor	1.437e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
Epithelial,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	4.849e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
NK,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	2.350e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CD44_receptor	2.289e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
Epithelial,cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CD44_receptor	2.214e-05	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
NK,cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CD44_receptor	1.074e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
NK,cells(Nos)_source	IL2_ligand	CD8+,T-cells(Nos)_target	IL2RB_IL2RG_receptor	3.978e-05	0.0	IL2	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	IL2_ligand	NK,cells(Nos)_target	IL2RB_IL2RG_receptor	6.505e-05	0.0	IL2	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	IL2_ligand	NK,cells(Nos)_target	IL2RB_IL2RG_receptor	3.359e-06	0.0	IL2	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	6.142e-05	0.01	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	Epithelial,cells(Nos)_target	TNFRSF1A_receptor	8.712e-06	0.0	TNF	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	TNFSF9_ligand	CD8+,T-cells(Nos)_target	TNFRSF9_receptor	8.116e-08	0.0	CD137	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	TNFSF9_ligand	Epithelial,cells(Nos)_target	TNFRSF9_receptor	2.030e-10	0.0	CD137	Secreted Signaling	KEGG: hsa04060
Epithelial,cells(Nos)_source	TNFSF9_ligand	NK,cells(Nos)_target	TNFRSF9_receptor	3.759e-08	0.0	CD137	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGA5_ITGB1_receptor	1.197e-06	0.0	CD40	Secreted Signaling	PMID: 28676852
NK,cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGA5_ITGB1_receptor	3.928e-08	0.0	CD40	Secreted Signaling	PMID: 28676852
Epithelial,cells(Nos)_source	NAMPT_ligand	CD8+,T-cells(Nos)_target	ITGA5_ITGB1_receptor	1.819e-05	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	Epithelial,cells(Nos)_target	ITGA5_ITGB1_receptor	8.389e-08	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	NAMPT_ligand	NK,cells(Nos)_target	ITGA5_ITGB1_receptor	1.357e-06	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
Epithelial,cells(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	PTPRC_receptor	8.165e-05	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Epithelial,cells(Nos)_source	LGALS9_ligand	Epithelial,cells(Nos)_target	PTPRC_receptor	6.034e-09	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
Epithelial,cells(Nos)_source	LGALS9_ligand	NK,cells(Nos)_target	PTPRC_receptor	3.470e-06	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
CD8+,T-cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.115e-03	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	BAG6_ligand	NK,cells(Nos)_target	NCR3_receptor	1.004e-06	0.0	BAG	Secreted Signaling	PMID: 30021652
Epithelial,cells(Nos)_source	BAG6_ligand	NK,cells(Nos)_target	NCR3_receptor	7.931e-07	0.0	BAG	Secreted Signaling	PMID: 30021652
NK,cells(Nos)_source	BAG6_ligand	NK,cells(Nos)_target	NCR3_receptor	4.638e-08	0.0	BAG	Secreted Signaling	PMID: 30021652
Epithelial,cells(Nos)_source	LGALS9_ligand	NK,cells(Nos)_target	HAVCR2_receptor	3.774e-07	0.0	GALECTIN	Secreted Signaling	PMID: 27192565
Epithelial,cells(Nos)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	2.918e-05	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	LGALS9_ligand	Epithelial,cells(Nos)_target	CD44_receptor	1.486e-08	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	LGALS9_ligand	NK,cells(Nos)_target	CD44_receptor	1.369e-06	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	4.029e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	Epithelial,cells(Nos)_target	CD74_receptor	1.232e-06	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	3.070e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
Epithelial,cells(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	1.805e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
NK,cells(Nos)_source	APP_ligand	NK,cells(Nos)_target	CD74_receptor	1.407e-06	0.01	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Nos)_source	CD48_ligand	CD8+,T-cells(Nos)_target	CD244_receptor	3.063e-05	0.02	CD48	Cell-Cell Contact	PMID: 26697006
NK,cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	6.997e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	6.997e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	3.189e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	LCK_ligand	CD8+,T-cells(Nos)_target	CD8 receptor_receptor	6.035e-02	0.0	LCK	Cell-Cell Contact	PMID: 25427562
NK,cells(Nos)_source	LCK_ligand	CD8+,T-cells(Nos)_target	CD8 receptor_receptor	2.704e-03	0.02	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.442e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	6.270e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.497e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	6.656e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	2.848e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.713e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.012e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.665e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	7.240e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.727e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	7.399e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.658e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	7.672e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.968e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.179e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	KIR2DL3_receptor	4.709e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	KIR2DL3_receptor	7.205e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	KIR2DL3_receptor	3.334e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	KIR3DL2_receptor	2.563e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
Epithelial,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	KIR3DL2_receptor	2.044e-07	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	KIR3DL2_receptor	1.044e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	KIR3DL2_receptor	3.887e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
Epithelial,cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	KIR3DL2_receptor	5.345e-06	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	KIR3DL2_receptor	1.665e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	LILRB1_receptor	6.132e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
Epithelial,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	LILRB1_receptor	4.645e-08	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	LILRB1_receptor	2.492e-05	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	5.026e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	2.115e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	5.621e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
Epithelial,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	8.350e-06	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	2.366e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
Epithelial,cells(Nos)_source	MPZL1_ligand	CD8+,T-cells(Nos)_target	MPZL1_receptor	9.738e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	MPZL1_ligand	CD8+,T-cells(Nos)_target	MPZL1_receptor	2.611e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	9.738e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	1.818e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	4.876e-09	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	MPZL1_ligand	NK,cells(Nos)_target	MPZL1_receptor	2.611e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	NK,cells(Nos)_target	MPZL1_receptor	4.876e-09	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	MPZL1_ligand	NK,cells(Nos)_target	MPZL1_receptor	1.307e-09	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	SELPLG_ligand	CD8+,T-cells(Nos)_target	SELL_receptor	1.174e-02	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607
NK,cells(Nos)_source	SELPLG_ligand	CD8+,T-cells(Nos)_target	SELL_receptor	5.159e-04	0.04	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607