Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5798833
Cell Line	None
Tissue type	High Grade Serous Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	33538
Initial cell number	10503
Post-QC gene number	6577
Post-QC cell number	4697

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Nos)_source	CCL4_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	4.674e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	5.948e-02	0.03	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	1.772e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	6.046e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	4.888e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	9.117e-05	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	4.314e-03	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	NK,cells(Nos)_target	TNFRSF1B_receptor	1.426e-03	0.0	TNF	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNFSF14_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	2.649e-04	0.0	LIGHT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF14_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	1.755e-04	0.0	LIGHT	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNFSF14_ligand	NK,cells(Nos)_target	TNFRSF14_receptor	1.106e-04	0.0	LIGHT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF10_ligand	CD8+,T-cells(Nos)_target	TNFRSF10A_receptor	7.685e-07	0.0	TRAIL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGA5_ITGB1_receptor	7.013e-06	0.0	CD40	Secreted Signaling	PMID: 28676852
NK,cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGA5_ITGB1_receptor	1.622e-06	0.0	CD40	Secreted Signaling	PMID: 28676852
CD8+,T-cells(Nos)_source	CD40LG_ligand	NK,cells(Nos)_target	ITGAM_ITGB2_receptor	3.644e-08	0.0	CD40	Secreted Signaling	PMID: 28676852
CD8+,T-cells(Nos)_source	GZMA_ligand	CD8+,T-cells(Nos)_target	F2R_receptor	1.578e-02	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD8+,T-cells(Nos)_source	CD48_ligand	NK,cells(Nos)_target	CD244_receptor	8.797e-07	0.0	CD48	Cell-Cell Contact	PMID: 26697006
NK,cells(Nos)_source	CD48_ligand	NK,cells(Nos)_target	CD244_receptor	2.580e-07	0.0	CD48	Cell-Cell Contact	PMID: 26697006
NK,cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	4.007e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	4.007e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	1.268e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	LCK_ligand	CD8+,T-cells(Nos)_target	CD8 receptor_receptor	1.325e-02	0.01	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Nos)_source	LCK_ligand	NK,cells(Nos)_target	CD8 receptor_receptor	1.306e-02	0.0	LCK	Cell-Cell Contact	PMID: 25427562
NK,cells(Nos)_source	LCK_ligand	NK,cells(Nos)_target	CD8 receptor_receptor	4.649e-03	0.0	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	4.298e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	1.168e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8B_receptor	5.039e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8B_receptor	1.393e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	4.652e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	1.346e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	5.592e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	1.573e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8B_receptor	2.815e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8B_receptor	7.525e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	KIR2DL3_receptor	2.508e-02	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	KIR2DL3_receptor	2.507e-02	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	KIR2DL3_receptor	7.310e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462