Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5798830
Cell Line	None
Tissue type	High Grade Serous Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	33562
Initial cell number	8019
Post-QC gene number	6674
Post-QC cell number	6190

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
NK,cells(Nos)_source	TGFB1_ligand	CD8+,T-cells(Nos)_target	TGFbR1_R2_receptor	4.701e-05	0.0	TGFb	Secreted Signaling	KEGG: hsa04350
NK,cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR1_receptor	6.904e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR1_receptor	6.966e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL5_ligand	NK,cells(Nos)_target	CCR1_receptor	4.257e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3_ligand	CD8+,T-cells(Nos)_target	CCR1_receptor	2.477e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3_ligand	NK,cells(Nos)_target	CCR1_receptor	1.539e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3L1_ligand	CD8+,T-cells(Nos)_target	CCR1_receptor	7.187e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	CCL3L1_ligand	NK,cells(Nos)_target	CCR1_receptor	4.480e-05	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	2.395e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
NK,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	2.006e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
NK,cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	2.631e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
NK,cells(Nos)_source	MIF_ligand	NK,cells(Nos)_target	CD74_CD44_receptor	1.273e-04	0.03	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
NK,cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	1.180e-04	0.0	TNF	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	TNF_ligand	NK,cells(Nos)_target	TNFRSF1B_receptor	1.650e-05	0.0	TNF	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	1.673e-04	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	NK,cells(Nos)_target	TNFRSF1B_receptor	2.383e-04	0.0	LT	Secreted Signaling	KEGG: hsa04060
NK,cells(Nos)_source	LTA_ligand	NK,cells(Nos)_target	TNFRSF1B_receptor	2.336e-05	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.535e-01	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8B_receptor	8.726e-03	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	1.186e-02	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	9.194e-02	0.02	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8B_receptor	5.492e-03	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRC1_receptor	5.589e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 24223577
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRC1_receptor	3.036e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	6.623e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2A_receptor	3.602e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	4.110e-03	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD94:NKG2E_receptor	2.229e-04	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462