Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5765328
Cell Line	None
Tissue type	Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	107556
Initial cell number	1409
Post-QC gene number	1139
Post-QC cell number	921

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	9.761e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	9.572e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	4.585e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	8.326e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	8.326e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	CD99_ligand	NK,cells(Nos)_target	CD99_receptor	1.505e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	5.054e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8A_receptor	8.933e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-A_ligand	NK,cells(Nos)_target	CD8A_receptor	1.275e-03	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	5.366e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	7.917e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8A_receptor	9.473e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	NK,cells(Nos)_target	CD8A_receptor	1.398e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	5.517e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	8.841e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	9.735e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8A_receptor	1.557e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	7.076e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.171e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8A_receptor	1.242e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8A_receptor	2.049e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	4.769e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8A_receptor	8.438e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-F_ligand	NK,cells(Nos)_target	CD8A_receptor	1.207e-03	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	2.611e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	2.780e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	4.102e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	2.862e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	4.606e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-C_ligand	NK,cells(Nos)_target	CD8B_receptor	6.624e-04	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	3.723e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	6.210e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	CD8B_receptor	8.936e-04	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	2.458e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	KLRK1_receptor	7.711e-02	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	KLRK1_receptor	1.275e-02	0.0	MHC-I	Cell-Cell Contact	PMID: 28484462
NK,cells(Nos)_source	HLA-E_ligand	NK,cells(Nos)_target	KLRK1_receptor	1.836e-03	0.04	MHC-I	Cell-Cell Contact	PMID: 28484462