Sample overview

Project Name	TCGA-OV
GSE ID	GSE195486
GSM ID	GSM5765320
Cell Line	None
Tissue type	Ovarian Cancer tumor tissue
Disease Type	High Grade Serous Ovarian Cancer tumor
PMID	35427494
Initial gene number	152491
Initial cell number	6056
Post-QC gene number	5428
Post-QC cell number	3490

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Good)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	1.894e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	1.173e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Good)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	2.615e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Good)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CD44_receptor	1.639e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Good)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	2.830e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD4+,T-cells(Nos)_source	CADM1_ligand	CD4+,T-cells(Nos)_target	CADM1_receptor	1.285e-05	0.04	CADM	Cell-Cell Contact	PMID: 24503895
CD8+,T-cells(Good)_source	CADM1_ligand	CD4+,T-cells(Nos)_target	CADM1_receptor	1.781e-05	0.04	CADM	Cell-Cell Contact	PMID: 24503895
CD8+,T-cells(Nos)_source	CADM1_ligand	CD4+,T-cells(Nos)_target	CADM1_receptor	3.136e-04	0.04	CADM	Cell-Cell Contact	PMID: 24503895
CD4+,T-cells(Nos)_source	CADM1_ligand	CD8+,T-cells(Good)_target	CADM1_receptor	1.781e-05	0.04	CADM	Cell-Cell Contact	PMID: 24503895
CD4+,T-cells(Nos)_source	CADM1_ligand	CD8+,T-cells(Nos)_target	CADM1_receptor	3.136e-04	0.04	CADM	Cell-Cell Contact	PMID: 24503895
CD8+,T-cells(Good)_source	CD99_ligand	CD8+,T-cells(Good)_target	CD99_receptor	2.202e-04	0.01	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Good)_target	CD99_receptor	1.786e-03	0.01	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.786e-03	0.01	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	LCK_ligand	CD4+,T-cells(Nos)_target	CD8 receptor_receptor	3.377e-06	0.04	LCK	Cell-Cell Contact	PMID: 25427562
CD4+,T-cells(Nos)_source	LCK_ligand	CD8+,T-cells(Good)_target	CD8 receptor_receptor	3.325e-05	0.0	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Good)_source	LCK_ligand	CD8+,T-cells(Good)_target	CD8 receptor_receptor	4.091e-05	0.0	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Nos)_source	LCK_ligand	CD8+,T-cells(Good)_target	CD8 receptor_receptor	7.808e-04	0.0	LCK	Cell-Cell Contact	PMID: 25427562
CD4+,T-cells(Nos)_source	LCK_ligand	CD8+,T-cells(Nos)_target	CD8 receptor_receptor	3.724e-04	0.01	LCK	Cell-Cell Contact	PMID: 25427562
CD8+,T-cells(Nos)_source	LCK_ligand	CD8+,T-cells(Nos)_target	CD8 receptor_receptor	8.665e-03	0.02	LCK	Cell-Cell Contact	PMID: 25427562
CD4+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	6.828e-05	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	3.949e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	5.929e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	3.039e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	5.621e-05	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	3.958e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	6.043e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	3.047e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	5.201e-05	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	3.826e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	5.693e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	2.937e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	1.088e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	4.916e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	7.894e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	3.866e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	PECAM1_ligand	CD4+,T-cells(Nos)_target	PECAM1_receptor	2.369e-05	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	PECAM1_ligand	CD4+,T-cells(Nos)_target	PECAM1_receptor	3.111e-05	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	PECAM1_ligand	CD4+,T-cells(Nos)_target	PECAM1_receptor	5.655e-04	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	PECAM1_ligand	CD8+,T-cells(Good)_target	PECAM1_receptor	3.111e-05	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	PECAM1_ligand	CD8+,T-cells(Nos)_target	PECAM1_receptor	5.655e-04	0.0	PECAM1	Cell-Cell Contact	KEGG: hsa04514