Sample overview
| Project Name | TCGA-LUAD |
| GSE ID | GSE236941 |
| GSM ID | GSM7586198 |
| Cell Line | Calu-3 |
| Tissue type | None |
| Disease Type | lung adenocarcinoma |
| PMID | \ |
| Initial gene number | 36601 |
| Initial cell number | 3099 |
| Post-QC gene number | 11217 |
| Post-QC cell number | 274 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Epithelial,cells(Nos)_source | TGFB2_ligand | Epithelial,cells(Good)_target | TGFbR1_R2_receptor | 1.043e-04 | 0.02 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | TGFB2_ligand | Epithelial,cells(Nos)_target | TGFbR1_R2_receptor | 4.357e-05 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | TGFB2_ligand | Epithelial,cells(Good)_target | ACVR1B_TGFbR2_receptor | 1.248e-04 | 0.01 | TGFb | Secreted Signaling | PMID: 27449815 |
| Epithelial,cells(Nos)_source | TGFB2_ligand | Epithelial,cells(Nos)_target | ACVR1B_TGFbR2_receptor | 5.215e-05 | 0.0 | TGFb | Secreted Signaling | PMID: 27449815 |
| Epithelial,cells(Nos)_source | TGFB2_ligand | Epithelial,cells(Good)_target | ACVR1_TGFbR_receptor | 6.689e-05 | 0.0 | TGFb | Secreted Signaling | PMID: 29376829 |
| Epithelial,cells(Nos)_source | TGFB2_ligand | Epithelial,cells(Nos)_target | ACVR1_TGFbR_receptor | 2.645e-05 | 0.0 | TGFb | Secreted Signaling | PMID: 29376829 |
| Epithelial,cells(Good)_source | FGF2_ligand | Epithelial,cells(Poor)_target | FGFR4_receptor | 5.489e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Epithelial,cells(Nos)_source | FGF2_ligand | Epithelial,cells(Poor)_target | FGFR4_receptor | 2.668e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Epithelial,cells(Poor)_source | FGF2_ligand | Epithelial,cells(Poor)_target | FGFR4_receptor | 6.618e-04 | 0.0 | FGF | Secreted Signaling | PMC: 4393358 |
| Epithelial,cells(Poor)_source | MIF_ligand | Epithelial,cells(Good)_target | CD74_CD44_receptor | 1.156e-02 | 0.03 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Epithelial,cells(Nos)_source | MDK_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 9.695e-04 | 0.04 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | MDK_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 3.519e-03 | 0.03 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | SEMA3C_ligand | Epithelial,cells(Poor)_target | NRP2_PLXNA1_receptor | 8.892e-05 | 0.01 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Epithelial,cells(Poor)_source | SEMA3C_ligand | Epithelial,cells(Poor)_target | NRP2_PLXNA1_receptor | 2.466e-04 | 0.04 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Epithelial,cells(Nos)_source | SEMA3C_ligand | Epithelial,cells(Poor)_target | NRP2_PLXNA2_receptor | 3.779e-05 | 0.0 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Epithelial,cells(Poor)_source | SEMA3C_ligand | Epithelial,cells(Poor)_target | NRP2_PLXNA2_receptor | 1.048e-04 | 0.01 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Epithelial,cells(Nos)_source | SEMA3C_ligand | Epithelial,cells(Nos)_target | NRP2_PLXNA3_receptor | 1.669e-05 | 0.0 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Epithelial,cells(Poor)_source | SEMA3C_ligand | Epithelial,cells(Nos)_target | NRP2_PLXNA3_receptor | 4.629e-05 | 0.0 | SEMA3 | Secreted Signaling | PMID: 27533782 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Good)_target | ITGA1_ITGB1_receptor | 1.343e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Nos)_target | ITGA1_ITGB1_receptor | 4.185e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Poor)_target | ITGA1_ITGB1_receptor | 1.517e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Nos)_target | ITGA1_ITGB1_receptor | 3.894e-04 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Poor)_target | ITGA1_ITGB1_receptor | 1.411e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Good)_target | ITGA1_ITGB1_receptor | 6.231e-03 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Nos)_target | ITGA1_ITGB1_receptor | 1.947e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Poor)_target | ITGA1_ITGB1_receptor | 7.053e-03 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA1_ITGB1_receptor | 4.336e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Poor)_target | ITGA1_ITGB1_receptor | 1.572e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Nos)_target | ITGA1_ITGB1_receptor | 4.828e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | ITGA1_ITGB1_receptor | 5.166e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | ITGA1_ITGB1_receptor | 1.750e-02 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Good)_target | ITGA2_ITGB1_receptor | 1.483e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 4.727e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Poor)_target | ITGA2_ITGB1_receptor | 1.707e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 4.429e-04 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Poor)_target | ITGA2_ITGB1_receptor | 1.598e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 2.211e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Poor)_target | ITGA2_ITGB1_receptor | 7.980e-03 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 4.896e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Poor)_target | ITGA2_ITGB1_receptor | 1.768e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 5.444e-03 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | ITGA2_ITGB1_receptor | 5.800e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | ITGA2_ITGB1_receptor | 1.966e-02 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Good)_target | ITGA3_ITGB1_receptor | 1.213e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Nos)_target | ITGA3_ITGB1_receptor | 4.440e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Poor)_target | ITGA3_ITGB1_receptor | 1.436e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Nos)_target | ITGA3_ITGB1_receptor | 4.144e-04 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Poor)_target | ITGA3_ITGB1_receptor | 1.332e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Nos)_target | ITGA3_ITGB1_receptor | 2.070e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Poor)_target | ITGA3_ITGB1_receptor | 6.665e-03 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA3_ITGB1_receptor | 1.325e-03 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA3_ITGB1_receptor | 4.599e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Poor)_target | ITGA3_ITGB1_receptor | 1.489e-02 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC2_ligand | Epithelial,cells(Nos)_target | ITGA3_ITGB1_receptor | 1.510e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Nos)_target | ITGA3_ITGB1_receptor | 5.118e-03 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | ITGA3_ITGB1_receptor | 4.898e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Good)_target | ITGA6_ITGB1_receptor | 1.518e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 4.943e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 1.794e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 4.644e-04 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 1.685e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 2.317e-03 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 8.410e-03 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 5.118e-03 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC1_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 5.350e-03 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 1.858e-02 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 5.689e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 6.091e-03 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | ITGA6_ITGB1_receptor | 2.066e-02 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Good)_target | ITGAV_ITGB8_receptor | 5.067e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 1.999e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Poor)_target | ITGAV_ITGB8_receptor | 4.815e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Good)_target | ITGAV_ITGB8_receptor | 4.558e-04 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 1.809e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA4_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 4.504e-04 | 0.01 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Good)_target | ITGAV_ITGB8_receptor | 2.293e-03 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 9.092e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 5.989e-04 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 2.074e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC2_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 6.877e-04 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB8_receptor | 2.321e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Good)_target | CD44_receptor | 6.208e-03 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Nos)_target | CD44_receptor | 2.372e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMA3_ligand | Epithelial,cells(Poor)_target | CD44_receptor | 8.619e-03 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Nos)_target | CD44_receptor | 2.157e-04 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMA4_ligand | Epithelial,cells(Poor)_target | CD44_receptor | 7.839e-04 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Nos)_target | CD44_receptor | 1.083e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMB1_ligand | Epithelial,cells(Poor)_target | CD44_receptor | 3.936e-03 | 0.02 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC1_ligand | Epithelial,cells(Poor)_target | CD44_receptor | 2.581e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC1_ligand | Epithelial,cells(Poor)_target | CD44_receptor | 8.942e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | CD44_receptor | 2.961e-03 | 0.03 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | LAMC2_ligand | Epithelial,cells(Poor)_target | CD44_receptor | 9.997e-03 | 0.04 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Poor)_source | MPZL1_ligand | Epithelial,cells(Poor)_target | MPZL1_receptor | 1.656e-03 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | OCLN_ligand | Epithelial,cells(Nos)_target | OCLN_receptor | 1.170e-04 | 0.04 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | SEMA7A_ligand | Epithelial,cells(Good)_target | ITGB1_ITGA1_receptor | 1.345e-04 | 0.01 | SEMA7 | Cell-Cell Contact | PMID: 22325954 |
| Epithelial,cells(Nos)_source | SEMA7A_ligand | Epithelial,cells(Nos)_target | ITGB1_ITGA1_receptor | 4.211e-05 | 0.01 | SEMA7 | Cell-Cell Contact | PMID: 22325954 |
| Epithelial,cells(Nos)_source | SEMA7A_ligand | Epithelial,cells(Poor)_target | ITGB1_ITGA1_receptor | 1.525e-04 | 0.01 | SEMA7 | Cell-Cell Contact | PMID: 22325954 |