Sample overview

Project Name	TCGA-LUAD
GSE ID	GSE139386
GSM ID	GSM4140332
Cell Line	H3122
Tissue type	None
Disease Type	lung adenocarcinoma
PMID	35999456
Initial gene number	32738
Initial cell number	4980
Post-QC gene number	8575
Post-QC cell number	3414

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_receptor	6.692e-06	0.02	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Poor)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_receptor	5.605e-07	0.01	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Nos)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_ERBB2_receptor	6.468e-06	0.03	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Poor)_source	TGFA_ligand	Epithelial,cells(Nos)_target	EGFR_ERBB2_receptor	5.417e-07	0.01	EGF	Secreted Signaling	KEGG: hsa04012
Epithelial,cells(Nos)_source	IGF2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	1.206e-04	0.0	IGF	Secreted Signaling	PMID: 28190785; PMID: 28873464
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	3.503e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	3.001e-02	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.416e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.070e-02	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Good)_source	MDK_ligand	Epithelial,cells(Nos)_target	NCL_receptor	4.428e-03	0.0	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	MDK_ligand	Epithelial,cells(Nos)_target	NCL_receptor	3.795e-02	0.01	MK	Secreted Signaling	PMID: 28356350
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	8.824e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Good)_target	ITGA2_ITGB1_receptor	4.598e-06	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.813e-05	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Poor)_target	ITGA2_ITGB1_receptor	3.426e-06	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL6A2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.069e-03	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	4.262e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.001e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	3.249e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Poor)_target	ITGA2_ITGB1_receptor	2.313e-05	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	1.137e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.643e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.059e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Poor)_target	ITGA2_ITGB1_receptor	2.889e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	4.377e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	3.554e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	1.245e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	5.078e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	4.438e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Poor)_target	ITGA3_ITGB1_receptor	3.054e-05	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	9.656e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Good)_target	ITGA3_ITGB1_receptor	5.367e-06	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	5.267e-05	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Poor)_target	ITGA3_ITGB1_receptor	3.623e-06	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL6A2_ligand	Epithelial,cells(Nos)_target	ITGA3_ITGB1_receptor	1.169e-03	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.589e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.103e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	7.350e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Good)_target	ITGA6_ITGB1_receptor	2.604e-05	0.03	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	3.006e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	2.629e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	8.680e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	7.053e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Poor)_target	ITGA6_ITGB4_receptor	5.191e-06	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	2.460e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	1.008e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	8.821e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Poor)_target	ITGA6_ITGB4_receptor	6.492e-06	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	3.424e-05	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	FN1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	2.580e-06	0.0	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Poor)_target	CD44_receptor	3.959e-06	0.01	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	FN1_ligand	Epithelial,cells(Poor)_target	CD44_receptor	2.983e-07	0.01	FN1	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	7.761e-05	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	5.932e-06	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Poor)_target	CD44_receptor	8.975e-06	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL1A1_ligand	Epithelial,cells(Poor)_target	CD44_receptor	6.859e-07	0.03	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Good)_target	CD44_receptor	3.065e-08	0.02	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	4.232e-06	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Poor)_target	CD44_receptor	4.894e-07	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL6A2_ligand	Epithelial,cells(Nos)_target	CD44_receptor	9.402e-05	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL6A2_ligand	Epithelial,cells(Poor)_target	CD44_receptor	1.087e-05	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	CD44_receptor	3.534e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Nos)_target	CD44_receptor	2.871e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMB3_ligand	Epithelial,cells(Poor)_target	CD44_receptor	4.085e-05	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMB3_ligand	Epithelial,cells(Poor)_target	CD44_receptor	3.320e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	1.001e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Good)_source	LAMC1_ligand	Epithelial,cells(Poor)_target	CD44_receptor	1.248e-06	0.04	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC1_ligand	Epithelial,cells(Poor)_target	CD44_receptor	1.157e-05	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	CD44_receptor	4.104e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Nos)_target	CD44_receptor	3.592e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMC2_ligand	Epithelial,cells(Poor)_target	CD44_receptor	4.744e-05	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	LAMC2_ligand	Epithelial,cells(Poor)_target	CD44_receptor	4.152e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL1A1_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	8.378e-04	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Good)_target	SDC1_receptor	5.090e-06	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	4.570e-05	0.01	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Poor)_source	COL6A1_ligand	Epithelial,cells(Poor)_target	SDC1_receptor	1.132e-06	0.02	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	COL6A2_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	1.015e-03	0.0	COLLAGEN	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	FN1_ligand	Epithelial,cells(Nos)_target	SDC1_receptor	3.698e-04	0.0	FN1	ECM-Receptor	KEGG: hsa04512