Sample overview
| Project Name |
TCGA-LGG
|
| GSE ID |
GSE152273
|
| GSM ID |
GSM4610546
|
| Cell Line |
None
|
| Tissue type |
Brain
|
| Disease Type |
primary glioma
|
| PMID |
34586841
|
| Initial gene number |
32738
|
| Initial cell number |
269
|
| Post-QC gene number |
11193
|
| Post-QC cell number |
155
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| Macrophages(Good)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
TGFbR1_R2_receptor |
1.718e-03 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Macrophages(Nos)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
TGFbR1_R2_receptor |
5.040e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Macrophages(Poor)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
TGFbR1_R2_receptor |
2.150e-03 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Macrophages(Poor)_source |
TGFB1_ligand |
Macrophages(Good)_target |
ACVR1B_TGFbR2_receptor |
2.578e-04 |
0.03 |
TGFb |
Secreted Signaling |
PMID: 27449815 |
| Macrophages(Good)_source |
TGFB1_ligand |
Macrophages(Nos)_target |
ACVR1B_TGFbR2_receptor |
8.349e-05 |
0.04 |
TGFb |
Secreted Signaling |
PMID: 27449815 |
| Macrophages(Good)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
ACVR1B_TGFbR2_receptor |
3.022e-04 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 27449815 |
| Macrophages(Nos)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
ACVR1B_TGFbR2_receptor |
8.867e-05 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 27449815 |
| Macrophages(Poor)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
ACVR1B_TGFbR2_receptor |
3.782e-04 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 27449815 |
| Macrophages(Good)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
ACVR1_TGFbR_receptor |
3.769e-04 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 29376829 |
| Macrophages(Nos)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
ACVR1_TGFbR_receptor |
1.076e-04 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 29376829 |
| Macrophages(Poor)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
ACVR1_TGFbR_receptor |
4.647e-04 |
0.0 |
TGFb |
Secreted Signaling |
PMID: 29376829 |
| Macrophages(Nos)_source |
IGF1_ligand |
Macrophages(Good)_target |
IGF1R_receptor |
1.886e-06 |
0.0 |
IGF |
Secreted Signaling |
PMID: 14604834 |
| Macrophages(Nos)_source |
IGF1_ligand |
Macrophages(Nos)_target |
IGF1R_receptor |
1.177e-06 |
0.03 |
IGF |
Secreted Signaling |
PMID: 14604834 |
| Macrophages(Nos)_source |
IGF1_ligand |
Macrophages(Poor)_target |
IGF1R_receptor |
2.386e-06 |
0.02 |
IGF |
Secreted Signaling |
PMID: 14604834 |
| Macrophages(Nos)_source |
IGF1_ligand |
Macrophages(Good)_target |
ITGA6_ITGB4_receptor |
1.499e-05 |
0.01 |
IGF |
Secreted Signaling |
PMID: 28190785; PMID: 28873464 |
| Macrophages(Nos)_source |
IGF1_ligand |
Macrophages(Nos)_target |
ITGA6_ITGB4_receptor |
5.810e-06 |
0.01 |
IGF |
Secreted Signaling |
PMID: 28190785; PMID: 28873464 |
| Macrophages(Nos)_source |
IGF1_ligand |
Macrophages(Poor)_target |
ITGA6_ITGB4_receptor |
1.796e-05 |
0.02 |
IGF |
Secreted Signaling |
PMID: 28190785; PMID: 28873464 |
| Macrophages(Poor)_source |
TNF_ligand |
Macrophages(Good)_target |
TNFRSF1A_receptor |
2.943e-04 |
0.03 |
TNF |
Secreted Signaling |
KEGG: hsa04060 |
| Macrophages(Good)_source |
CD40LG_ligand |
Macrophages(Good)_target |
ITGAM_ITGB2_receptor |
1.985e-05 |
0.0 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| Macrophages(Poor)_source |
CD40LG_ligand |
Macrophages(Good)_target |
ITGAM_ITGB2_receptor |
1.989e-05 |
0.0 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| Macrophages(Good)_source |
CD40LG_ligand |
Macrophages(Nos)_target |
ITGAM_ITGB2_receptor |
5.428e-06 |
0.01 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| Macrophages(Good)_source |
CD40LG_ligand |
Macrophages(Poor)_target |
ITGAM_ITGB2_receptor |
2.478e-05 |
0.0 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| Macrophages(Poor)_source |
CD40LG_ligand |
Macrophages(Poor)_target |
ITGAM_ITGB2_receptor |
2.484e-05 |
0.02 |
CD40 |
Secreted Signaling |
PMID: 28676852 |
| Macrophages(Nos)_source |
SPP1_ligand |
Macrophages(Poor)_target |
ITGA4_ITGB1_receptor |
1.226e-03 |
0.03 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Macrophages(Poor)_source |
SPP1_ligand |
Macrophages(Poor)_target |
ITGA4_ITGB1_receptor |
5.333e-03 |
0.04 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Fibroblasts(Poor)_target |
ITGA4_ITGB1_receptor |
9.116e-08 |
0.03 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Macrophages(Good)_target |
ITGA4_ITGB1_receptor |
1.275e-04 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Macrophages(Nos)_target |
ITGA4_ITGB1_receptor |
3.766e-05 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Macrophages(Poor)_target |
ITGA4_ITGB1_receptor |
1.644e-04 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Fibroblasts(Poor)_target |
ITGA6_ITGB1_receptor |
1.069e-07 |
0.03 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Macrophages(Good)_target |
ITGA6_ITGB1_receptor |
1.649e-04 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Macrophages(Nos)_target |
ITGA6_ITGB1_receptor |
6.132e-05 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Fibroblasts(Poor)_source |
MDK_ligand |
Macrophages(Poor)_target |
ITGA6_ITGB1_receptor |
2.204e-04 |
0.0 |
MK |
Secreted Signaling |
PMID: 28356350 |
| Macrophages(Good)_source |
C3_ligand |
Macrophages(Poor)_target |
C3AR1_receptor |
7.968e-03 |
0.01 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Poor)_target |
C3AR1_receptor |
1.055e-02 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Good)_target |
ITGAM_ITGB2_receptor |
5.339e-03 |
0.0 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Good)_source |
C3_ligand |
Macrophages(Poor)_target |
ITGAM_ITGB2_receptor |
5.021e-03 |
0.0 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Poor)_target |
ITGAM_ITGB2_receptor |
6.662e-03 |
0.0 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Good)_target |
ITGAX_ITGB2_receptor |
5.584e-03 |
0.01 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Nos)_target |
ITGAX_ITGB2_receptor |
1.787e-03 |
0.01 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Good)_source |
C3_ligand |
Macrophages(Poor)_target |
ITGAX_ITGB2_receptor |
5.452e-03 |
0.0 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Nos)_source |
C3_ligand |
Macrophages(Poor)_target |
ITGAX_ITGB2_receptor |
1.542e-03 |
0.02 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Poor)_target |
ITGAX_ITGB2_receptor |
7.231e-03 |
0.0 |
COMPLEMENT |
Secreted Signaling |
PMID: 16234578 |
| Macrophages(Poor)_source |
APP_ligand |
Macrophages(Good)_target |
CD74_receptor |
3.678e-04 |
0.03 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Macrophages(Poor)_source |
APP_ligand |
Macrophages(Poor)_target |
CD74_receptor |
5.061e-04 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Macrophages(Good)_source |
CD40LG_ligand |
Macrophages(Good)_target |
CD40_receptor |
2.508e-07 |
0.0 |
CD40 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
CD40LG_ligand |
Macrophages(Good)_target |
CD40_receptor |
2.514e-07 |
0.0 |
CD40 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
CD40LG_ligand |
Macrophages(Poor)_target |
CD40_receptor |
2.514e-07 |
0.0 |
CD40 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
CNTN2_ligand |
Macrophages(Good)_target |
CNTN2_receptor |
4.049e-09 |
0.04 |
CNTN |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
CNTN2_ligand |
Macrophages(Good)_target |
CNTN2_receptor |
1.646e-08 |
0.0 |
CNTN |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
CNTN2_ligand |
Macrophages(Nos)_target |
CNTN2_receptor |
4.049e-09 |
0.04 |
CNTN |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
CNTN2_ligand |
Macrophages(Poor)_target |
CNTN2_receptor |
1.646e-08 |
0.0 |
CNTN |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
HLA-DPB1_ligand |
Macrophages(Good)_target |
CD4_receptor |
1.266e-03 |
0.01 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
HLA-DMB_ligand |
Macrophages(Good)_target |
CD4_receptor |
1.001e-03 |
0.02 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
HLA-DMB_ligand |
Macrophages(Good)_target |
CD4_receptor |
1.007e-03 |
0.01 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
HLA-DRA_ligand |
Macrophages(Good)_target |
CD4_receptor |
5.682e-03 |
0.01 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
HLA-DRA_ligand |
Macrophages(Good)_target |
CD4_receptor |
1.897e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
HLA-DRA_ligand |
Macrophages(Good)_target |
CD4_receptor |
5.747e-03 |
0.03 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
HLA-DRB1_ligand |
Macrophages(Good)_target |
CD4_receptor |
3.030e-03 |
0.02 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
HLA-DRB1_ligand |
Macrophages(Good)_target |
CD4_receptor |
9.861e-04 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
HLA-DRB1_ligand |
Macrophages(Good)_target |
CD4_receptor |
2.905e-03 |
0.02 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
HLA-DRB1_ligand |
Macrophages(Poor)_target |
CD4_receptor |
2.350e-03 |
0.03 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
MPZL1_ligand |
Macrophages(Good)_target |
MPZL1_receptor |
9.375e-05 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Good)_source |
MPZL1_ligand |
Macrophages(Nos)_target |
MPZL1_receptor |
9.375e-05 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
MPZL1_ligand |
Macrophages(Nos)_target |
MPZL1_receptor |
7.658e-05 |
0.01 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
MPZL1_ligand |
Macrophages(Nos)_target |
MPZL1_receptor |
9.932e-05 |
0.03 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
MPZL1_ligand |
Macrophages(Poor)_target |
MPZL1_receptor |
9.932e-05 |
0.03 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |