Sample overview
| Project Name |
TCGA-LGG
|
| GSE ID |
GSE152273
|
| GSM ID |
GSM4610543
|
| Cell Line |
None
|
| Tissue type |
Brain
|
| Disease Type |
primary glioma
|
| PMID |
34586841
|
| Initial gene number |
32738
|
| Initial cell number |
2487
|
| Post-QC gene number |
3325
|
| Post-QC cell number |
663
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| Macrophages(Nos)_source |
TGFB1_ligand |
Macrophages(Nos)_target |
TGFbR1_R2_receptor |
7.509e-05 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Macrophages(Poor)_source |
TGFB1_ligand |
Macrophages(Nos)_target |
TGFbR1_R2_receptor |
1.200e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Macrophages(Nos)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
TGFbR1_R2_receptor |
7.743e-05 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Macrophages(Poor)_source |
TGFB1_ligand |
Macrophages(Poor)_target |
TGFbR1_R2_receptor |
1.238e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Macrophages(Nos)_source |
SPP1_ligand |
Macrophages(Nos)_target |
ITGAV_ITGB1_receptor |
6.682e-05 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Macrophages(Poor)_source |
SPP1_ligand |
Macrophages(Nos)_target |
ITGAV_ITGB1_receptor |
1.088e-04 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Neurons(Good)_source |
SPP1_ligand |
Macrophages(Nos)_target |
ITGAV_ITGB1_receptor |
1.300e-05 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Neurons(Nos)_source |
SPP1_ligand |
Macrophages(Nos)_target |
ITGAV_ITGB1_receptor |
9.968e-06 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Macrophages(Nos)_source |
SPP1_ligand |
Macrophages(Poor)_target |
ITGAV_ITGB1_receptor |
1.050e-04 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Macrophages(Poor)_source |
SPP1_ligand |
Macrophages(Poor)_target |
ITGAV_ITGB1_receptor |
1.710e-04 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Neurons(Good)_source |
SPP1_ligand |
Macrophages(Poor)_target |
ITGAV_ITGB1_receptor |
2.043e-05 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Neurons(Nos)_source |
SPP1_ligand |
Macrophages(Poor)_target |
ITGAV_ITGB1_receptor |
1.566e-05 |
0.0 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Neurons(Good)_source |
PTN_ligand |
Neurons(Good)_target |
PTPRZ1_receptor |
1.482e-04 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Nos)_source |
PTN_ligand |
Neurons(Good)_target |
PTPRZ1_receptor |
6.792e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Good)_source |
PTN_ligand |
Neurons(Nos)_target |
PTPRZ1_receptor |
1.041e-04 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Nos)_source |
PTN_ligand |
Neurons(Nos)_target |
PTPRZ1_receptor |
4.773e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Good)_source |
PTN_ligand |
Adipocytes(Good)_target |
NCL_receptor |
1.218e-09 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Nos)_source |
PTN_ligand |
Adipocytes(Good)_target |
NCL_receptor |
5.574e-10 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Good)_source |
PTN_ligand |
Macrophages(Nos)_target |
NCL_receptor |
6.839e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Nos)_source |
PTN_ligand |
Macrophages(Nos)_target |
NCL_receptor |
3.132e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Good)_source |
PTN_ligand |
Macrophages(Poor)_target |
NCL_receptor |
1.072e-04 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Nos)_source |
PTN_ligand |
Macrophages(Poor)_target |
NCL_receptor |
4.911e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Good)_source |
PTN_ligand |
Neurons(Good)_target |
NCL_receptor |
6.275e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Nos)_source |
PTN_ligand |
Neurons(Good)_target |
NCL_receptor |
2.873e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Good)_source |
PTN_ligand |
Neurons(Nos)_target |
NCL_receptor |
7.538e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Neurons(Nos)_source |
PTN_ligand |
Neurons(Nos)_target |
NCL_receptor |
3.453e-05 |
0.0 |
PTN |
Secreted Signaling |
PMID: 28356350; PMID: 25620911 |
| Adipocytes(Good)_source |
C3_ligand |
Macrophages(Nos)_target |
C3AR1_receptor |
1.246e-11 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Macrophages(Nos)_source |
C3_ligand |
Macrophages(Nos)_target |
C3AR1_receptor |
4.984e-04 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Nos)_target |
C3AR1_receptor |
6.518e-04 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Neurons(Good)_source |
C3_ligand |
Macrophages(Nos)_target |
C3AR1_receptor |
4.370e-10 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Neurons(Nos)_source |
C3_ligand |
Macrophages(Nos)_target |
C3AR1_receptor |
3.469e-10 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Adipocytes(Good)_source |
C3_ligand |
Macrophages(Poor)_target |
C3AR1_receptor |
1.666e-11 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Macrophages(Nos)_source |
C3_ligand |
Macrophages(Poor)_target |
C3AR1_receptor |
6.687e-04 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Macrophages(Poor)_source |
C3_ligand |
Macrophages(Poor)_target |
C3AR1_receptor |
8.741e-04 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Neurons(Good)_source |
C3_ligand |
Macrophages(Poor)_target |
C3AR1_receptor |
5.844e-10 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Neurons(Nos)_source |
C3_ligand |
Macrophages(Poor)_target |
C3AR1_receptor |
4.640e-10 |
0.0 |
COMPLEMENT |
Secreted Signaling |
KEGG: hsa04080 |
| Macrophages(Nos)_source |
GRN_ligand |
Adipocytes(Good)_target |
SORT1_receptor |
7.053e-10 |
0.03 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Poor)_source |
GRN_ligand |
Adipocytes(Good)_target |
SORT1_receptor |
6.470e-10 |
0.04 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Nos)_source |
GRN_ligand |
Macrophages(Nos)_target |
SORT1_receptor |
7.420e-05 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Poor)_source |
GRN_ligand |
Macrophages(Nos)_target |
SORT1_receptor |
6.818e-05 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Nos)_source |
GRN_ligand |
Macrophages(Poor)_target |
SORT1_receptor |
7.863e-06 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Poor)_source |
GRN_ligand |
Macrophages(Poor)_target |
SORT1_receptor |
7.214e-06 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Nos)_source |
GRN_ligand |
Neurons(Good)_target |
SORT1_receptor |
7.541e-07 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Poor)_source |
GRN_ligand |
Neurons(Good)_target |
SORT1_receptor |
6.918e-07 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Nos)_source |
GRN_ligand |
Neurons(Nos)_target |
SORT1_receptor |
5.196e-07 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Poor)_source |
GRN_ligand |
Neurons(Nos)_target |
SORT1_receptor |
4.767e-07 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Macrophages(Nos)_source |
LGALS9_ligand |
Macrophages(Nos)_target |
PTPRC_receptor |
2.656e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Macrophages(Poor)_source |
LGALS9_ligand |
Macrophages(Nos)_target |
PTPRC_receptor |
3.768e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Macrophages(Nos)_source |
LGALS9_ligand |
Macrophages(Poor)_target |
PTPRC_receptor |
2.188e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Macrophages(Poor)_source |
LGALS9_ligand |
Macrophages(Poor)_target |
PTPRC_receptor |
3.103e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Macrophages(Nos)_source |
LGALS9_ligand |
Macrophages(Nos)_target |
HAVCR2_receptor |
1.289e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| Macrophages(Poor)_source |
LGALS9_ligand |
Macrophages(Nos)_target |
HAVCR2_receptor |
1.829e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| Macrophages(Nos)_source |
LGALS9_ligand |
Macrophages(Poor)_target |
HAVCR2_receptor |
1.654e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| Macrophages(Poor)_source |
LGALS9_ligand |
Macrophages(Poor)_target |
HAVCR2_receptor |
2.346e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| Macrophages(Nos)_source |
APP_ligand |
Macrophages(Nos)_target |
CD74_receptor |
3.537e-05 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Macrophages(Poor)_source |
APP_ligand |
Macrophages(Nos)_target |
CD74_receptor |
3.488e-05 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Neurons(Nos)_source |
APP_ligand |
Macrophages(Nos)_target |
CD74_receptor |
9.409e-06 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Macrophages(Nos)_source |
APP_ligand |
Macrophages(Poor)_target |
CD74_receptor |
5.194e-05 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Macrophages(Poor)_source |
APP_ligand |
Macrophages(Poor)_target |
CD74_receptor |
5.121e-05 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Neurons(Nos)_source |
APP_ligand |
Macrophages(Poor)_target |
CD74_receptor |
1.381e-05 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Macrophages(Nos)_source |
CD99_ligand |
Macrophages(Nos)_target |
CD99_receptor |
9.350e-04 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
CD99_ligand |
Macrophages(Nos)_target |
CD99_receptor |
6.478e-04 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
CD99_ligand |
Macrophages(Poor)_target |
CD99_receptor |
6.478e-04 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
CD99_ligand |
Macrophages(Poor)_target |
CD99_receptor |
4.419e-04 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
MPZL1_ligand |
Macrophages(Nos)_target |
MPZL1_receptor |
1.919e-05 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
MPZL1_ligand |
Macrophages(Nos)_target |
MPZL1_receptor |
1.751e-05 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Good)_source |
MPZL1_ligand |
Macrophages(Nos)_target |
MPZL1_receptor |
6.877e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Nos)_source |
MPZL1_ligand |
Macrophages(Nos)_target |
MPZL1_receptor |
2.537e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
MPZL1_ligand |
Macrophages(Poor)_target |
MPZL1_receptor |
1.751e-05 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
MPZL1_ligand |
Macrophages(Poor)_target |
MPZL1_receptor |
1.597e-05 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Good)_source |
MPZL1_ligand |
Macrophages(Poor)_target |
MPZL1_receptor |
6.272e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Nos)_source |
MPZL1_ligand |
Macrophages(Poor)_target |
MPZL1_receptor |
2.314e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
MPZL1_ligand |
Neurons(Good)_target |
MPZL1_receptor |
6.877e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
MPZL1_ligand |
Neurons(Good)_target |
MPZL1_receptor |
6.272e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Good)_source |
MPZL1_ligand |
Neurons(Good)_target |
MPZL1_receptor |
2.463e-08 |
0.03 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Nos)_source |
MPZL1_ligand |
Neurons(Nos)_target |
MPZL1_receptor |
2.537e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Macrophages(Poor)_source |
MPZL1_ligand |
Neurons(Nos)_target |
MPZL1_receptor |
2.314e-07 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Good)_source |
NCAM1_ligand |
Neurons(Good)_target |
NCAM1_receptor |
2.354e-04 |
0.0 |
NCAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Nos)_source |
NCAM1_ligand |
Neurons(Good)_target |
NCAM1_receptor |
2.073e-05 |
0.0 |
NCAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Good)_source |
NCAM1_ligand |
Neurons(Nos)_target |
NCAM1_receptor |
2.073e-05 |
0.0 |
NCAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Nos)_source |
NCAM1_ligand |
Neurons(Nos)_target |
NCAM1_receptor |
1.813e-06 |
0.0 |
NCAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neurons(Nos)_source |
DLL3_ligand |
Adipocytes(Good)_target |
NOTCH1_receptor |
2.509e-10 |
0.0 |
NOTCH |
Cell-Cell Contact |
PMID: 22353464 |
| Neurons(Nos)_source |
DLL3_ligand |
Macrophages(Nos)_target |
NOTCH1_receptor |
4.323e-08 |
0.0 |
NOTCH |
Cell-Cell Contact |
PMID: 22353464 |
| Neurons(Nos)_source |
DLL3_ligand |
Macrophages(Poor)_target |
NOTCH1_receptor |
5.529e-08 |
0.0 |
NOTCH |
Cell-Cell Contact |
PMID: 22353464 |
| Neurons(Nos)_source |
DLL3_ligand |
Neurons(Good)_target |
NOTCH1_receptor |
2.416e-08 |
0.0 |
NOTCH |
Cell-Cell Contact |
PMID: 22353464 |
| Neurons(Nos)_source |
DLL3_ligand |
Neurons(Nos)_target |
NOTCH1_receptor |
1.759e-08 |
0.0 |
NOTCH |
Cell-Cell Contact |
PMID: 22353464 |