Sample overview
| Project Name | TCGA-LGG |
| GSE ID | GSE152273 |
| GSM ID | GSM4610542 |
| Cell Line | None |
| Tissue type | Brain |
| Disease Type | primary glioma |
| PMID | 34586841 |
| Initial gene number | 32738 |
| Initial cell number | 2566 |
| Post-QC gene number | 2369 |
| Post-QC cell number | 625 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Macrophages(Good)_source | SPP1_ligand | Macrophages(Good)_target | ITGAV_ITGB1_receptor | 3.120e-05 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Nos)_source | SPP1_ligand | Macrophages(Good)_target | ITGAV_ITGB1_receptor | 9.523e-05 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Poor)_source | SPP1_ligand | Macrophages(Good)_target | ITGAV_ITGB1_receptor | 2.816e-04 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Neurons(Nos)_source | SPP1_ligand | Macrophages(Good)_target | ITGAV_ITGB1_receptor | 1.587e-05 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Good)_source | SPP1_ligand | Macrophages(Nos)_target | ITGAV_ITGB1_receptor | 7.283e-06 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Nos)_source | SPP1_ligand | Macrophages(Nos)_target | ITGAV_ITGB1_receptor | 2.202e-05 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Poor)_source | SPP1_ligand | Macrophages(Nos)_target | ITGAV_ITGB1_receptor | 6.584e-05 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Neurons(Nos)_source | SPP1_ligand | Macrophages(Nos)_target | ITGAV_ITGB1_receptor | 3.565e-06 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Good)_source | SPP1_ligand | Macrophages(Poor)_target | ITGAV_ITGB1_receptor | 2.798e-06 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Nos)_source | SPP1_ligand | Macrophages(Poor)_target | ITGAV_ITGB1_receptor | 8.458e-06 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Poor)_source | SPP1_ligand | Macrophages(Poor)_target | ITGAV_ITGB1_receptor | 2.530e-05 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Neurons(Nos)_source | SPP1_ligand | Macrophages(Poor)_target | ITGAV_ITGB1_receptor | 1.367e-06 | 0.0 | SPP1 | Secreted Signaling | PMID: 21907263 |
| Macrophages(Good)_source | PTN_ligand | Macrophages(Good)_target | PTPRZ1_receptor | 1.272e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Neurons(Good)_target | PTPRZ1_receptor | 8.880e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Neurons(Nos)_target | PTPRZ1_receptor | 4.460e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Adipocytes(Good)_target | NCL_receptor | 5.274e-10 | 0.03 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Adipocytes(Nos)_target | NCL_receptor | 7.822e-11 | 0.03 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Macrophages(Good)_target | NCL_receptor | 2.764e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Macrophages(Nos)_target | NCL_receptor | 2.029e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Macrophages(Poor)_target | NCL_receptor | 5.055e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Neurons(Good)_target | NCL_receptor | 5.350e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Macrophages(Good)_source | PTN_ligand | Neurons(Nos)_target | NCL_receptor | 4.441e-06 | 0.0 | PTN | Secreted Signaling | PMID: 28356350; PMID: 25620911 |
| Adipocytes(Good)_source | C3_ligand | Macrophages(Nos)_target | C3AR1_receptor | 2.644e-11 | 0.01 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | C3_ligand | Macrophages(Nos)_target | C3AR1_receptor | 4.152e-12 | 0.01 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Macrophages(Good)_source | C3_ligand | Macrophages(Nos)_target | C3AR1_receptor | 5.894e-06 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Macrophages(Nos)_source | C3_ligand | Macrophages(Nos)_target | C3AR1_receptor | 2.064e-04 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Macrophages(Poor)_source | C3_ligand | Macrophages(Nos)_target | C3AR1_receptor | 4.815e-04 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Neurons(Good)_source | C3_ligand | Macrophages(Nos)_target | C3AR1_receptor | 2.343e-10 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Neurons(Nos)_source | C3_ligand | Macrophages(Nos)_target | C3AR1_receptor | 1.172e-10 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Good)_source | C3_ligand | Macrophages(Poor)_target | C3AR1_receptor | 5.678e-11 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | C3_ligand | Macrophages(Poor)_target | C3AR1_receptor | 8.916e-12 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Macrophages(Good)_source | C3_ligand | Macrophages(Poor)_target | C3AR1_receptor | 1.266e-05 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Macrophages(Nos)_source | C3_ligand | Macrophages(Poor)_target | C3AR1_receptor | 4.439e-04 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Macrophages(Poor)_source | C3_ligand | Macrophages(Poor)_target | C3AR1_receptor | 1.035e-03 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Neurons(Good)_source | C3_ligand | Macrophages(Poor)_target | C3AR1_receptor | 5.032e-10 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Neurons(Nos)_source | C3_ligand | Macrophages(Poor)_target | C3AR1_receptor | 2.517e-10 | 0.0 | COMPLEMENT | Secreted Signaling | KEGG: hsa04080 |
| Macrophages(Nos)_source | GRN_ligand | Adipocytes(Good)_target | SORT1_receptor | 9.080e-10 | 0.01 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Poor)_source | GRN_ligand | Adipocytes(Good)_target | SORT1_receptor | 2.191e-09 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Nos)_source | GRN_ligand | Adipocytes(Nos)_target | SORT1_receptor | 1.291e-10 | 0.01 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Poor)_source | GRN_ligand | Adipocytes(Nos)_target | SORT1_receptor | 3.115e-10 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Good)_source | GRN_ligand | Macrophages(Good)_target | SORT1_receptor | 3.234e-06 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Nos)_source | GRN_ligand | Macrophages(Good)_target | SORT1_receptor | 1.350e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Poor)_source | GRN_ligand | Macrophages(Good)_target | SORT1_receptor | 3.256e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Good)_source | GRN_ligand | Macrophages(Nos)_target | SORT1_receptor | 6.251e-06 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Nos)_source | GRN_ligand | Macrophages(Nos)_target | SORT1_receptor | 2.610e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Poor)_source | GRN_ligand | Macrophages(Nos)_target | SORT1_receptor | 6.295e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Good)_source | GRN_ligand | Macrophages(Poor)_target | SORT1_receptor | 2.379e-07 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Nos)_source | GRN_ligand | Macrophages(Poor)_target | SORT1_receptor | 9.933e-07 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Poor)_source | GRN_ligand | Macrophages(Poor)_target | SORT1_receptor | 2.396e-06 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Good)_source | GRN_ligand | Neurons(Good)_target | SORT1_receptor | 5.768e-09 | 0.02 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Nos)_source | GRN_ligand | Neurons(Good)_target | SORT1_receptor | 2.409e-08 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Poor)_source | GRN_ligand | Neurons(Good)_target | SORT1_receptor | 5.811e-08 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Nos)_source | GRN_ligand | Neurons(Nos)_target | SORT1_receptor | 2.569e-09 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Poor)_source | GRN_ligand | Neurons(Nos)_target | SORT1_receptor | 6.199e-09 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Macrophages(Good)_source | PSAP_ligand | Macrophages(Good)_target | GPR37L1_receptor | 2.254e-06 | 0.0 | PSAP | Secreted Signaling | PMID: 23690594 |
| Macrophages(Nos)_source | PSAP_ligand | Macrophages(Good)_target | GPR37L1_receptor | 2.855e-06 | 0.0 | PSAP | Secreted Signaling | PMID: 23690594 |
| Macrophages(Poor)_source | PSAP_ligand | Macrophages(Good)_target | GPR37L1_receptor | 1.635e-05 | 0.0 | PSAP | Secreted Signaling | PMID: 23690594 |
| Macrophages(Good)_source | APP_ligand | Macrophages(Good)_target | CD74_receptor | 1.907e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Nos)_source | APP_ligand | Macrophages(Good)_target | CD74_receptor | 2.739e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Poor)_source | APP_ligand | Macrophages(Good)_target | CD74_receptor | 6.700e-06 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Good)_source | APP_ligand | Macrophages(Nos)_target | CD74_receptor | 7.797e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Nos)_source | APP_ligand | Macrophages(Nos)_target | CD74_receptor | 1.122e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Poor)_source | APP_ligand | Macrophages(Nos)_target | CD74_receptor | 2.746e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Good)_source | APP_ligand | Macrophages(Poor)_target | CD74_receptor | 2.486e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Nos)_source | APP_ligand | Macrophages(Poor)_target | CD74_receptor | 3.623e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Poor)_source | APP_ligand | Macrophages(Poor)_target | CD74_receptor | 8.864e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Macrophages(Good)_source | CD99_ligand | Macrophages(Good)_target | CD99_receptor | 6.869e-06 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Nos)_source | CD99_ligand | Macrophages(Good)_target | CD99_receptor | 2.425e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Poor)_source | CD99_ligand | Macrophages(Good)_target | CD99_receptor | 4.706e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Good)_source | CD99_ligand | Macrophages(Nos)_target | CD99_receptor | 2.425e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Nos)_source | CD99_ligand | Macrophages(Nos)_target | CD99_receptor | 8.560e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Poor)_source | CD99_ligand | Macrophages(Nos)_target | CD99_receptor | 1.661e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Good)_source | CD99_ligand | Macrophages(Poor)_target | CD99_receptor | 4.706e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Nos)_source | CD99_ligand | Macrophages(Poor)_target | CD99_receptor | 1.661e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Poor)_source | CD99_ligand | Macrophages(Poor)_target | CD99_receptor | 3.223e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Good)_source | JAM3_ligand | Macrophages(Good)_target | JAM3_receptor | 4.697e-06 | 0.0 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Nos)_source | MPZL1_ligand | Macrophages(Good)_target | MPZL1_receptor | 1.910e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Poor)_source | MPZL1_ligand | Macrophages(Good)_target | MPZL1_receptor | 2.215e-08 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Good)_source | MPZL1_ligand | Macrophages(Nos)_target | MPZL1_receptor | 1.910e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Nos)_source | MPZL1_ligand | Macrophages(Nos)_target | MPZL1_receptor | 5.853e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Poor)_source | MPZL1_ligand | Macrophages(Nos)_target | MPZL1_receptor | 6.789e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Good)_source | MPZL1_ligand | Macrophages(Nos)_target | MPZL1_receptor | 3.005e-09 | 0.03 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Good)_source | MPZL1_ligand | Macrophages(Poor)_target | MPZL1_receptor | 2.215e-08 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Nos)_source | MPZL1_ligand | Macrophages(Poor)_target | MPZL1_receptor | 6.789e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Poor)_source | MPZL1_ligand | Macrophages(Poor)_target | MPZL1_receptor | 7.873e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Good)_source | MPZL1_ligand | Macrophages(Poor)_target | MPZL1_receptor | 3.485e-09 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Nos)_source | MPZL1_ligand | Neurons(Good)_target | MPZL1_receptor | 3.005e-09 | 0.03 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Poor)_source | MPZL1_ligand | Neurons(Good)_target | MPZL1_receptor | 3.485e-09 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Macrophages(Good)_source | NCAM1_ligand | Macrophages(Good)_target | NCAM1_receptor | 5.945e-05 | 0.0 | NCAM | Cell-Cell Contact | KEGG: hsa04514 |