Sample overview
| Project Name |
TCGA-LAML
|
| GSE ID |
GSE243227
|
| GSM ID |
GSM7781089
|
| Cell Line |
None
|
| Tissue type |
bone marrow
|
| Disease Type |
de-novo AML1
|
| PMID |
38167262
|
| Initial gene number |
36601
|
| Initial cell number |
1571
|
| Post-QC gene number |
3426
|
| Post-QC cell number |
1080
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
CD8+,T-cells(Nos)_target |
CD74_CXCR4_receptor |
2.435e-05 |
0.01 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
CD8+,T-cells(Nos)_target |
CD74_CXCR4_receptor |
4.463e-04 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
HSC(Nos)_target |
CD74_CXCR4_receptor |
3.412e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CXCR4_receptor |
5.031e-04 |
0.02 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CXCR4_receptor |
9.259e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CD44_receptor |
1.249e-03 |
0.01 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CD44_receptor |
2.276e-02 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source |
NAMPT_ligand |
HSC(Nos)_target |
ITGA5_ITGB1_receptor |
3.227e-03 |
0.03 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Neutrophils(Nos)_source |
NAMPT_ligand |
HSC(Nos)_target |
ITGA5_ITGB1_receptor |
2.135e-04 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Monocytes(Nos)_source |
NAMPT_ligand |
Monocytes(Nos)_target |
ITGA5_ITGB1_receptor |
9.328e-03 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Neutrophils(Nos)_source |
NAMPT_ligand |
Monocytes(Nos)_target |
ITGA5_ITGB1_receptor |
6.155e-04 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| CD8+,T-cells(Nos)_source |
ANXA1_ligand |
Monocytes(Nos)_target |
FPR1_receptor |
6.443e-04 |
0.01 |
ANNEXIN |
Secreted Signaling |
PMID: 23230437 |
| HSC(Nos)_source |
ANXA1_ligand |
Monocytes(Nos)_target |
FPR1_receptor |
1.763e-02 |
0.0 |
ANNEXIN |
Secreted Signaling |
PMID: 23230437 |
| Monocytes(Nos)_source |
ANXA1_ligand |
Monocytes(Nos)_target |
FPR1_receptor |
3.492e-02 |
0.0 |
ANNEXIN |
Secreted Signaling |
PMID: 23230437 |
| Neutrophils(Nos)_source |
ANXA1_ligand |
Monocytes(Nos)_target |
FPR1_receptor |
1.197e-03 |
0.0 |
ANNEXIN |
Secreted Signaling |
PMID: 23230437 |
| Monocytes(Nos)_source |
GRN_ligand |
Monocytes(Nos)_target |
SORT1_receptor |
1.296e-02 |
0.0 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Monocytes(Nos)_source |
GRN_ligand |
Neutrophils(Nos)_target |
SORT1_receptor |
8.102e-04 |
0.04 |
GRN |
Secreted Signaling |
PMID: 29555433 |
| Monocytes(Nos)_source |
THBS1_ligand |
Monocytes(Nos)_target |
CD36_receptor |
4.877e-02 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
Neutrophils(Nos)_target |
CD36_receptor |
2.383e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
HSC(Nos)_target |
CD47_receptor |
4.927e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Neutrophils(Nos)_source |
THBS1_ligand |
HSC(Nos)_target |
CD47_receptor |
1.701e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
Monocytes(Nos)_target |
CD47_receptor |
3.960e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| HSC(Nos)_source |
ADGRE5_ligand |
Monocytes(Nos)_target |
CD55_receptor |
1.636e-02 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| Monocytes(Nos)_source |
ADGRE5_ligand |
Monocytes(Nos)_target |
CD55_receptor |
4.113e-02 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| Monocytes(Nos)_source |
ADGRE5_ligand |
Neutrophils(Nos)_target |
CD55_receptor |
2.089e-03 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| HSC(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
PILRA_receptor |
4.007e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
PMID: 18234675 |
| Monocytes(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
PILRA_receptor |
7.484e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
PMID: 18234675 |
| HSC(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
2.939e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
5.575e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
CD99_receptor |
5.575e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
Monocytes(Nos)_target |
ITGAL_ITGB2_receptor |
2.810e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ICAM2_ligand |
Monocytes(Nos)_target |
ITGAL_ITGB2_receptor |
6.323e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
Monocytes(Nos)_target |
ITGAM_ITGB2_receptor |
3.412e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ICAM2_ligand |
Monocytes(Nos)_target |
ITGAM_ITGB2_receptor |
7.676e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ITGB2_ligand |
Monocytes(Nos)_target |
ICAM2_receptor |
1.136e-02 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DPA1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
2.741e-02 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DPB1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
2.263e-02 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DQB1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
1.321e-02 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DRA_ligand |
Monocytes(Nos)_target |
CD4_receptor |
4.153e-02 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DRB1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
2.855e-02 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DRB5_ligand |
Monocytes(Nos)_target |
CD4_receptor |
3.410e-02 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
PECAM1_ligand |
Monocytes(Nos)_target |
PECAM1_receptor |
4.774e-02 |
0.0 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Neutrophils(Nos)_source |
PECAM1_ligand |
Monocytes(Nos)_target |
PECAM1_receptor |
2.045e-03 |
0.0 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
PECAM1_ligand |
Neutrophils(Nos)_target |
PECAM1_receptor |
2.045e-03 |
0.0 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
SELPLG_ligand |
Monocytes(Nos)_target |
SELL_receptor |
7.029e-03 |
0.0 |
SELPLG |
Cell-Cell Contact |
PMC2431087; PMID: 8892633,PMID: 8896607 |
| Monocytes(Nos)_source |
SEMA4D_ligand |
Monocytes(Nos)_target |
PLXNB2_receptor |
1.423e-03 |
0.0 |
SEMA4 |
Cell-Cell Contact |
PMID: 27533782 |
| Neutrophils(Nos)_source |
SEMA4D_ligand |
Monocytes(Nos)_target |
PLXNB2_receptor |
1.376e-04 |
0.04 |
SEMA4 |
Cell-Cell Contact |
PMID: 27533782 |