Sample overview
| Project Name | TCGA-LAML |
| GSE ID | GSE235923 |
| GSM ID | GSM7512025 |
| Cell Line | None |
| Tissue type | Bone Marrow |
| Disease Type | AML with mutated RUNX1 |
| PMID | 37798266 |
| Initial gene number | 36613 |
| Initial cell number | 4430 |
| Post-QC gene number | 6630 |
| Post-QC cell number | 1025 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| HSC(Nos)_source | TGFB1_ligand | Monocytes(Nos)_target | TGFbR1_R2_receptor | 8.630e-04 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| Monocytes(Nos)_source | TGFB1_ligand | Monocytes(Nos)_target | TGFbR1_R2_receptor | 4.630e-04 | 0.0 | TGFb | Secreted Signaling | KEGG: hsa04350 |
| B-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 5.690e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 3.798e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 1.576e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 6.623e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source | MIF_ligand | HSC(Nos)_target | CD74_CD44_receptor | 3.024e-02 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 1.651e-02 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | NAMPT_ligand | HSC(Nos)_target | ITGA5_ITGB1_receptor | 1.881e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | Monocytes(Nos)_target | ITGA5_ITGB1_receptor | 1.253e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| B-cells(Nos)_source | MDK_ligand | B-cells(Nos)_target | ITGA4_ITGB1_receptor | 1.090e-05 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | CD8+,T-cells(Nos)_target | ITGA4_ITGB1_receptor | 3.043e-06 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | ITGA4_ITGB1_receptor | 4.345e-06 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | HSC(Nos)_target | ITGA4_ITGB1_receptor | 2.627e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | Monocytes(Nos)_target | ITGA4_ITGB1_receptor | 1.452e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | B-cells(Nos)_target | NCL_receptor | 1.859e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | CD8+,T-cells(Nos)_target | NCL_receptor | 8.500e-05 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | Erythrocytes(Nos)_target | NCL_receptor | 9.339e-06 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | HSC(Nos)_target | NCL_receptor | 9.733e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| B-cells(Nos)_source | MDK_ligand | Monocytes(Nos)_target | NCL_receptor | 4.364e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| HSC(Nos)_source | LGALS9_ligand | HSC(Nos)_target | CD44_receptor | 1.470e-02 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| Monocytes(Nos)_source | LGALS9_ligand | HSC(Nos)_target | CD44_receptor | 6.167e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | LGALS9_ligand | Monocytes(Nos)_target | CD44_receptor | 7.430e-03 | 0.0 | GALECTIN | Secreted Signaling | PMID: 25065622 |
| HSC(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 2.118e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 1.094e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| HSC(Nos)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 6.464e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | CD99_ligand | HSC(Nos)_target | CD99_receptor | 2.588e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 2.588e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ICAM1_ligand | HSC(Nos)_target | ITGAX_ITGB2_receptor | 6.455e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 16252253 |
| HSC(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAX_ITGB2_receptor | 7.502e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 16252253 |
| Monocytes(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAX_ITGB2_receptor | 5.915e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 16252253 |
| Monocytes(Nos)_source | ICAM1_ligand | HSC(Nos)_target | ITGAL_ITGB2_receptor | 2.974e-04 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAL_ITGB2_receptor | 3.212e-04 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAL_ITGB2_receptor | 2.536e-04 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ICAM1_ligand | HSC(Nos)_target | ITGAM_ITGB2_receptor | 1.901e-06 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAM_ITGB2_receptor | 1.557e-06 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAM_ITGB2_receptor | 1.231e-06 | 0.0 | ICAM | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ICAM1_ligand | HSC(Nos)_target | ITGAL_receptor | 8.341e-05 | 0.0 | ICAM | Cell-Cell Contact | PMID: 23602662 |
| HSC(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAL_receptor | 1.012e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 23602662 |
| Monocytes(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAL_receptor | 7.999e-05 | 0.0 | ICAM | Cell-Cell Contact | PMID: 23602662 |
| HSC(Nos)_source | ICAM1_ligand | HSC(Nos)_target | SPN_receptor | 1.881e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 1683685 |
| Monocytes(Nos)_source | ICAM1_ligand | HSC(Nos)_target | SPN_receptor | 1.486e-04 | 0.0 | ICAM | Cell-Cell Contact | PMID: 1683685 |
| Monocytes(Nos)_source | ITGB2_ligand | HSC(Nos)_target | ICAM1_receptor | 1.016e-03 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | ITGB2_ligand | Monocytes(Nos)_target | ICAM1_receptor | 1.056e-03 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | ITGB2_ligand | Monocytes(Nos)_target | ICAM1_receptor | 8.003e-04 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPA1_ligand | HSC(Nos)_target | CD4_receptor | 1.044e-02 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | HLA-DPA1_ligand | Monocytes(Nos)_target | CD4_receptor | 2.226e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DPA1_ligand | Monocytes(Nos)_target | CD4_receptor | 1.041e-02 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPA1_ligand | Monocytes(Nos)_target | CD4_receptor | 7.311e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | HLA-DPB1_ligand | HSC(Nos)_target | CD4_receptor | 3.757e-03 | 0.01 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPB1_ligand | HSC(Nos)_target | CD4_receptor | 1.104e-02 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | HLA-DPB1_ligand | Monocytes(Nos)_target | CD4_receptor | 2.637e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DPB1_ligand | Monocytes(Nos)_target | CD4_receptor | 1.123e-02 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPB1_ligand | Monocytes(Nos)_target | CD4_receptor | 7.717e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQA1_ligand | B-cells(Nos)_target | CD4_receptor | 3.861e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQA1_ligand | HSC(Nos)_target | CD4_receptor | 2.326e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQA1_ligand | Monocytes(Nos)_target | CD4_receptor | 1.661e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMA_ligand | HSC(Nos)_target | CD4_receptor | 6.922e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | HLA-DMA_ligand | Monocytes(Nos)_target | CD4_receptor | 1.398e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DMA_ligand | Monocytes(Nos)_target | CD4_receptor | 7.255e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMA_ligand | Monocytes(Nos)_target | CD4_receptor | 4.888e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMB_ligand | B-cells(Nos)_target | CD4_receptor | 4.675e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMB_ligand | HSC(Nos)_target | CD4_receptor | 2.814e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMB_ligand | Monocytes(Nos)_target | CD4_receptor | 2.007e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DOA_ligand | B-cells(Nos)_target | CD4_receptor | 4.980e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DOA_ligand | CD8+,T-cells(Nos)_target | CD4_receptor | 4.711e-06 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DOA_ligand | Erythrocytes(Nos)_target | CD4_receptor | 3.711e-06 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DOA_ligand | HSC(Nos)_target | CD4_receptor | 3.008e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DOA_ligand | Monocytes(Nos)_target | CD4_receptor | 2.158e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQB1_ligand | B-cells(Nos)_target | CD4_receptor | 5.990e-04 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQB1_ligand | HSC(Nos)_target | CD4_receptor | 3.601e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DQB1_ligand | Monocytes(Nos)_target | CD4_receptor | 1.765e-03 | 0.01 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQB1_ligand | Monocytes(Nos)_target | CD4_receptor | 2.564e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRA_ligand | HSC(Nos)_target | CD4_receptor | 1.348e-02 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | HLA-DRA_ligand | Monocytes(Nos)_target | CD4_receptor | 3.231e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DRA_ligand | Monocytes(Nos)_target | CD4_receptor | 1.525e-02 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRA_ligand | Monocytes(Nos)_target | CD4_receptor | 9.373e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB1_ligand | HSC(Nos)_target | CD4_receptor | 7.269e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | HLA-DRB1_ligand | Monocytes(Nos)_target | CD4_receptor | 1.454e-03 | 0.01 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DRB1_ligand | Monocytes(Nos)_target | CD4_receptor | 8.511e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB1_ligand | Monocytes(Nos)_target | CD4_receptor | 5.128e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DRB5_ligand | HSC(Nos)_target | CD4_receptor | 1.486e-02 | 0.02 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB5_ligand | HSC(Nos)_target | CD4_receptor | 8.524e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | HLA-DRB5_ligand | Monocytes(Nos)_target | CD4_receptor | 1.047e-02 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB5_ligand | Monocytes(Nos)_target | CD4_receptor | 5.997e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | MPZL1_ligand | B-cells(Nos)_target | MPZL1_receptor | 9.702e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | B-cells(Nos)_target | MPZL1_receptor | 2.345e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 2.345e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | MPZL1_ligand | HSC(Nos)_target | MPZL1_receptor | 5.669e-05 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | NEGR1_ligand | HSC(Nos)_target | NEGR1_receptor | 3.156e-04 | 0.0 | NEGR | Cell-Cell Contact | KEGG: hsa04514 |
| HSC(Nos)_source | SELL_ligand | HSC(Nos)_target | CD34_receptor | 4.966e-04 | 0.0 | SELL | Cell-Cell Contact | PMID: 7692600; PMID: 8977216 |