Sample overview
| Project Name |
TCGA-LAML
|
| GSE ID |
GSE235923
|
| GSM ID |
GSM7512019
|
| Cell Line |
None
|
| Tissue type |
Bone Marrow
|
| Disease Type |
AML with myelodysplasia-related changes
|
| PMID |
37798266
|
| Initial gene number |
36613
|
| Initial cell number |
4278
|
| Post-QC gene number |
7520
|
| Post-QC cell number |
2381
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| Monocytes(Nos)_source |
TGFB1_ligand |
Erythrocytes(Nos)_target |
TGFbR1_R2_receptor |
1.198e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Erythrocytes(Nos)_source |
TGFB1_ligand |
Monocytes(Nos)_target |
TGFbR1_R2_receptor |
1.347e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Monocytes(Nos)_source |
TGFB1_ligand |
Monocytes(Nos)_target |
TGFbR1_R2_receptor |
1.748e-04 |
0.0 |
TGFb |
Secreted Signaling |
KEGG: hsa04350 |
| Monocytes(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CXCR4_receptor |
1.038e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| Monocytes(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CD44_receptor |
8.491e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source |
RETN_ligand |
Erythrocytes(Nos)_target |
TLR4_receptor |
3.970e-07 |
0.0 |
RESISTIN |
Secreted Signaling |
PMID: 30809105 |
| Monocytes(Nos)_source |
RETN_ligand |
Monocytes(Nos)_target |
TLR4_receptor |
2.469e-04 |
0.0 |
RESISTIN |
Secreted Signaling |
PMID: 30809105 |
| Monocytes(Nos)_source |
RETN_ligand |
Erythrocytes(Nos)_target |
CAP1_receptor |
3.114e-04 |
0.0 |
RESISTIN |
Secreted Signaling |
PMID: 30809105 |
| Monocytes(Nos)_source |
RETN_ligand |
Monocytes(Nos)_target |
CAP1_receptor |
1.776e-03 |
0.0 |
RESISTIN |
Secreted Signaling |
PMID: 30809105 |
| Monocytes(Nos)_source |
NAMPT_ligand |
Erythrocytes(Nos)_target |
INSR_receptor |
6.591e-05 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Monocytes(Nos)_source |
NAMPT_ligand |
Monocytes(Nos)_target |
INSR_receptor |
2.943e-05 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Monocytes(Nos)_source |
NAMPT_ligand |
Erythrocytes(Nos)_target |
ITGA5_ITGB1_receptor |
3.962e-03 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Monocytes(Nos)_source |
NAMPT_ligand |
Monocytes(Nos)_target |
ITGA5_ITGB1_receptor |
3.270e-03 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Erythrocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
PTPRC_receptor |
4.628e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
PTPRC_receptor |
1.282e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Erythrocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
HAVCR2_receptor |
7.851e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| Monocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
HAVCR2_receptor |
2.156e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| Erythrocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
CD44_receptor |
5.751e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
CD44_receptor |
1.597e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Erythrocytes(Nos)_source |
TNXB_ligand |
Monocytes(Nos)_target |
SDC4_receptor |
2.078e-04 |
0.0 |
TENASCIN |
ECM-Receptor |
KEGG: hsa04512 |
| Erythrocytes(Nos)_source |
THBS1_ligand |
Monocytes(Nos)_target |
SDC4_receptor |
7.499e-05 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
Monocytes(Nos)_target |
SDC4_receptor |
1.917e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
Erythrocytes(Nos)_target |
CD36_receptor |
2.617e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
Erythrocytes(Nos)_target |
CD47_receptor |
3.504e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
Monocytes(Nos)_target |
CD47_receptor |
2.842e-04 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
ADGRE5_ligand |
Erythrocytes(Nos)_target |
CD55_receptor |
5.919e-04 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| Monocytes(Nos)_source |
ADGRE5_ligand |
Monocytes(Nos)_target |
CD55_receptor |
9.570e-04 |
0.0 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| Erythrocytes(Nos)_source |
APP_ligand |
Monocytes(Nos)_target |
CD74_receptor |
5.242e-04 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Monocytes(Nos)_source |
APP_ligand |
Monocytes(Nos)_target |
CD74_receptor |
1.065e-03 |
0.0 |
APP |
Cell-Cell Contact |
PMID: 19849849 |
| Erythrocytes(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
PILRA_receptor |
2.465e-04 |
0.0 |
CD99 |
Cell-Cell Contact |
PMID: 18234675 |
| Monocytes(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
PILRA_receptor |
1.244e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
PMID: 18234675 |
| Monocytes(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
CD99_receptor |
1.182e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ICAM1_ligand |
Erythrocytes(Nos)_target |
ITGAX_ITGB2_receptor |
3.211e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 16252253 |
| Monocytes(Nos)_source |
ICAM1_ligand |
Monocytes(Nos)_target |
ITGAX_ITGB2_receptor |
2.579e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 16252253 |
| Monocytes(Nos)_source |
ICAM1_ligand |
Erythrocytes(Nos)_target |
ITGAM_ITGB2_receptor |
7.733e-07 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
ICAM1_ligand |
Monocytes(Nos)_target |
ITGAM_ITGB2_receptor |
1.500e-05 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ICAM1_ligand |
Monocytes(Nos)_target |
ITGAM_ITGB2_receptor |
1.002e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
ICAM2_ligand |
Monocytes(Nos)_target |
ITGAM_ITGB2_receptor |
1.973e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ICAM1_ligand |
Erythrocytes(Nos)_target |
SPN_receptor |
9.105e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| Monocytes(Nos)_source |
ITGB2_ligand |
Monocytes(Nos)_target |
ICAM1_receptor |
3.073e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ITGB2_ligand |
Erythrocytes(Nos)_target |
ICAM2_receptor |
6.131e-04 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
F11R_ligand |
Erythrocytes(Nos)_target |
F11R_receptor |
8.296e-05 |
0.0 |
JAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-F_ligand |
Monocytes(Nos)_target |
LILRB1_receptor |
2.928e-04 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| Monocytes(Nos)_source |
HLA-DPA1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
4.269e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DPB1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
4.420e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DQA1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
9.815e-04 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
HLA-DMA_ligand |
Monocytes(Nos)_target |
CD4_receptor |
3.970e-04 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DMA_ligand |
Monocytes(Nos)_target |
CD4_receptor |
2.393e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DQB1_ligand |
Erythrocytes(Nos)_target |
CD4_receptor |
7.837e-05 |
0.01 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DQB1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
1.379e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DRA_ligand |
Monocytes(Nos)_target |
CD4_receptor |
7.138e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DRB1_ligand |
Monocytes(Nos)_target |
CD4_receptor |
2.811e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DRB5_ligand |
Erythrocytes(Nos)_target |
CD4_receptor |
1.133e-04 |
0.02 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
HLA-DRB5_ligand |
Monocytes(Nos)_target |
CD4_receptor |
1.985e-03 |
0.0 |
MHC-II |
Cell-Cell Contact |
KEGG: hsa04514 |
| Erythrocytes(Nos)_source |
MPZL1_ligand |
Erythrocytes(Nos)_target |
MPZL1_receptor |
2.051e-06 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
PECAM1_ligand |
Monocytes(Nos)_target |
PECAM1_receptor |
4.190e-04 |
0.0 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |