Sample overview
| Project Name |
TCGA-LAML
|
| GSE ID |
GSE235923
|
| GSM ID |
GSM7512014
|
| Cell Line |
None
|
| Tissue type |
Bone Marrow
|
| Disease Type |
AML, t(8;21)(q22;q22) RUNX1-RUNX1T1
|
| PMID |
37798266
|
| Initial gene number |
33538
|
| Initial cell number |
2276
|
| Post-QC gene number |
1601
|
| Post-QC cell number |
146
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| Monocytes(Good)_source |
MIF_ligand |
Monocytes(Good)_target |
CD74_CD44_receptor |
1.246e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source |
MIF_ligand |
Monocytes(Poor)_target |
CD74_CD44_receptor |
3.343e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| Monocytes(Good)_source |
MIF_ligand |
Monocytes(Poor)_target |
CD74_CD44_receptor |
4.066e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| Monocytes(Poor)_source |
MIF_ligand |
Monocytes(Poor)_target |
CD74_CD44_receptor |
1.078e-02 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source |
MIF_ligand |
Monocytes(Poor)_target |
CD74_CD44_receptor |
3.030e-03 |
0.03 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| Monocytes(Good)_source |
LGALS9_ligand |
Monocytes(Good)_target |
PTPRC_receptor |
6.254e-04 |
0.01 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Poor)_source |
LGALS9_ligand |
Monocytes(Good)_target |
PTPRC_receptor |
1.394e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Good)_source |
LGALS9_ligand |
Monocytes(Poor)_target |
PTPRC_receptor |
1.659e-03 |
0.03 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Poor)_source |
LGALS9_ligand |
Monocytes(Poor)_target |
PTPRC_receptor |
3.691e-03 |
0.01 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| Monocytes(Poor)_source |
LGALS9_ligand |
CD4+,T-cells(Nos)_target |
CD44_receptor |
7.834e-04 |
0.04 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Poor)_source |
LGALS9_ligand |
CD4+,T-cells(Poor)_target |
CD44_receptor |
1.343e-03 |
0.01 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Poor)_source |
LGALS9_ligand |
Monocytes(Good)_target |
CD44_receptor |
1.302e-03 |
0.01 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Good)_source |
LGALS9_ligand |
Monocytes(Poor)_target |
CD44_receptor |
2.068e-03 |
0.02 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Poor)_source |
LGALS9_ligand |
Monocytes(Poor)_target |
CD44_receptor |
4.615e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Good)_source |
LGALS9_ligand |
NK,cells(Nos)_target |
CD44_receptor |
5.515e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Poor)_source |
LGALS9_ligand |
NK,cells(Nos)_target |
CD44_receptor |
1.230e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| NK,cells(Nos)_source |
ADGRE5_ligand |
Monocytes(Good)_target |
CD55_receptor |
4.275e-04 |
0.04 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| NK,cells(Nos)_source |
ADGRE5_ligand |
NK,cells(Nos)_target |
CD55_receptor |
4.405e-04 |
0.01 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| Monocytes(Good)_source |
CD99_ligand |
Monocytes(Good)_target |
CD99_receptor |
5.248e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
CD99_ligand |
Monocytes(Good)_target |
CD99_receptor |
1.510e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
CD99_ligand |
Monocytes(Good)_target |
CD99_receptor |
4.084e-03 |
0.01 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Good)_source |
CD99_ligand |
Monocytes(Poor)_target |
CD99_receptor |
1.510e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
CD99_ligand |
Monocytes(Poor)_target |
CD99_receptor |
4.333e-02 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
CD99_ligand |
Monocytes(Poor)_target |
CD99_receptor |
1.169e-02 |
0.01 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Good)_source |
CD99_ligand |
NK,cells(Nos)_target |
CD99_receptor |
4.084e-03 |
0.01 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
CD99_ligand |
NK,cells(Nos)_target |
CD99_receptor |
1.169e-02 |
0.01 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
ICAM1_ligand |
Monocytes(Good)_target |
ITGAM_ITGB2_receptor |
2.578e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Good)_source |
ICAM1_ligand |
Monocytes(Poor)_target |
ITGAM_ITGB2_receptor |
3.373e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
ICAM1_ligand |
Monocytes(Poor)_target |
ITGAM_ITGB2_receptor |
1.378e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| NK,cells(Nos)_source |
ICAM1_ligand |
Monocytes(Poor)_target |
ITGAM_ITGB2_receptor |
2.016e-04 |
0.01 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Good)_source |
ICAM1_ligand |
Monocytes(Good)_target |
SPN_receptor |
9.159e-05 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| Monocytes(Poor)_source |
ICAM1_ligand |
Monocytes(Good)_target |
SPN_receptor |
3.744e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| NK,cells(Nos)_source |
ICAM1_ligand |
Monocytes(Good)_target |
SPN_receptor |
5.472e-05 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| Monocytes(Poor)_source |
ICAM1_ligand |
Monocytes(Poor)_target |
SPN_receptor |
3.357e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| Monocytes(Poor)_source |
ICAM1_ligand |
NK,cells(Nos)_target |
SPN_receptor |
1.505e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| Monocytes(Poor)_source |
ITGB2_ligand |
Monocytes(Good)_target |
ICAM1_receptor |
8.605e-04 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
ITGB2_ligand |
Monocytes(Poor)_target |
ICAM1_receptor |
3.498e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
ITGB2_ligand |
NK,cells(Nos)_target |
ICAM1_receptor |
5.166e-04 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
PECAM1_ligand |
Monocytes(Good)_target |
PECAM1_receptor |
8.774e-05 |
0.01 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Good)_source |
PECAM1_ligand |
Monocytes(Poor)_target |
PECAM1_receptor |
8.774e-05 |
0.01 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Poor)_source |
PECAM1_ligand |
Monocytes(Poor)_target |
PECAM1_receptor |
4.335e-04 |
0.0 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |