Sample overview
| Project Name |
TCGA-LAML
|
| GSE ID |
GSE182150
|
| GSM ID |
GSM5519367
|
| Cell Line |
14-00613
|
| Tissue type |
None
|
| Disease Type |
Acute Myeloid Leukemia
|
| PMID |
35590033
|
| Initial gene number |
33546
|
| Initial cell number |
2492
|
| Post-QC gene number |
6003
|
| Post-QC cell number |
257
|
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster
vs
There are no results of the analysis here
Overall Survival : Cluster
vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster
vs
There
are no results of the analysis here
Tumor Size : Cluster
vs
There
are no results of the analysis here
Lymph Node Involvement : Cluster
vs
There
are no results of the analysis here
Distant Metastasis : Cluster
vs
There
are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type |
Ligand |
Receiving Cell Type |
Receptor |
Score |
P-value |
Pathway Name |
Function |
Evidence |
| CD8+,T-cells(Nos)_source |
CCL5_ligand |
CD8+,T-cells(Nos)_target |
CCR1_receptor |
1.874e-03 |
0.0 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| Monocytes(Nos)_source |
CCL5_ligand |
CD8+,T-cells(Nos)_target |
CCR1_receptor |
8.034e-04 |
0.02 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source |
CCL5_ligand |
Monocytes(Nos)_target |
CCR1_receptor |
3.709e-03 |
0.0 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| Monocytes(Nos)_source |
CCL5_ligand |
Monocytes(Nos)_target |
CCR1_receptor |
1.590e-03 |
0.02 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| Monocytes(Nos)_source |
CCL3_ligand |
CD8+,T-cells(Nos)_target |
CCR1_receptor |
7.228e-04 |
0.0 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| Monocytes(Nos)_source |
CCL3_ligand |
Monocytes(Nos)_target |
CCR1_receptor |
1.430e-03 |
0.0 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| Monocytes(Nos)_source |
CCL3L1_ligand |
CD8+,T-cells(Nos)_target |
CCR1_receptor |
7.764e-04 |
0.0 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| Monocytes(Nos)_source |
CCL3L1_ligand |
HSC(Nos)_target |
CCR1_receptor |
1.497e-05 |
0.0 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| Monocytes(Nos)_source |
CCL3L1_ligand |
Monocytes(Nos)_target |
CCR1_receptor |
1.536e-03 |
0.0 |
CCL |
Secreted Signaling |
KEGG: hsa04060 |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
CD8+,T-cells(Nos)_target |
CD74_CXCR4_receptor |
8.506e-04 |
0.03 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
CD8+,T-cells(Nos)_target |
CD74_CXCR4_receptor |
5.658e-04 |
0.01 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
HSC(Nos)_target |
CD74_CXCR4_receptor |
1.434e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| HSC(Nos)_source |
MIF_ligand |
HSC(Nos)_target |
CD74_CXCR4_receptor |
9.546e-04 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
HSC(Nos)_target |
CD74_CD44_receptor |
1.049e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source |
MIF_ligand |
HSC(Nos)_target |
CD74_CD44_receptor |
6.977e-04 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CD44_receptor |
2.408e-03 |
0.0 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source |
MIF_ligand |
Monocytes(Nos)_target |
CD74_CD44_receptor |
1.602e-03 |
0.01 |
MIF |
Secreted Signaling |
PMID: 29637711; PMID: 26175090 |
| HSC(Nos)_source |
SPP1_ligand |
Monocytes(Nos)_target |
ITGAV_ITGB1_receptor |
9.131e-05 |
0.01 |
SPP1 |
Secreted Signaling |
PMID: 21907263 |
| Monocytes(Nos)_source |
NAMPT_ligand |
HSC(Nos)_target |
ITGA5_ITGB1_receptor |
2.886e-03 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| Monocytes(Nos)_source |
NAMPT_ligand |
Monocytes(Nos)_target |
ITGA5_ITGB1_receptor |
8.857e-03 |
0.0 |
VISFATIN |
Secreted Signaling |
PMID: 28490838 |
| HSC(Nos)_source |
LGALS9_ligand |
CD8+,T-cells(Nos)_target |
PTPRC_receptor |
6.138e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| HSC(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
PTPRC_receptor |
3.468e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| HSC(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
PTPRC_receptor |
8.523e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 30120235 |
| HSC(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
HAVCR2_receptor |
3.387e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| Monocytes(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
HAVCR2_receptor |
1.621e-04 |
0.04 |
GALECTIN |
Secreted Signaling |
PMID: 27192565 |
| HSC(Nos)_source |
LGALS9_ligand |
CD8+,T-cells(Nos)_target |
CD44_receptor |
1.596e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| HSC(Nos)_source |
LGALS9_ligand |
HSC(Nos)_target |
CD44_receptor |
8.911e-04 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| HSC(Nos)_source |
LGALS9_ligand |
Monocytes(Nos)_target |
CD44_receptor |
4.258e-03 |
0.0 |
GALECTIN |
Secreted Signaling |
PMID: 25065622 |
| Monocytes(Nos)_source |
THBS1_ligand |
Monocytes(Nos)_target |
SDC4_receptor |
1.297e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
CD8+,T-cells(Nos)_target |
CD47_receptor |
2.313e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
HSC(Nos)_target |
CD47_receptor |
2.119e-03 |
0.0 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| Monocytes(Nos)_source |
THBS1_ligand |
Monocytes(Nos)_target |
CD47_receptor |
1.390e-03 |
0.03 |
THBS |
ECM-Receptor |
KEGG: hsa04512 |
| HSC(Nos)_source |
ADGRE5_ligand |
HSC(Nos)_target |
CD55_receptor |
1.231e-04 |
0.02 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| HSC(Nos)_source |
ADGRE5_ligand |
Monocytes(Nos)_target |
CD55_receptor |
3.312e-04 |
0.02 |
ADGRE5 |
Cell-Cell Contact |
PMID: 11297558 |
| CD8+,T-cells(Nos)_source |
PTPRC_ligand |
Monocytes(Nos)_target |
MRC1_receptor |
6.258e-03 |
0.0 |
CD45 |
Cell-Cell Contact |
PMID: 27601670; PMID: 10575006 |
| HSC(Nos)_source |
PTPRC_ligand |
Monocytes(Nos)_target |
MRC1_receptor |
3.482e-03 |
0.0 |
CD45 |
Cell-Cell Contact |
PMID: 27601670; PMID: 10575006 |
| Monocytes(Nos)_source |
PTPRC_ligand |
Monocytes(Nos)_target |
MRC1_receptor |
8.464e-03 |
0.0 |
CD45 |
Cell-Cell Contact |
PMID: 27601670; PMID: 10575006 |
| CD8+,T-cells(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
PILRA_receptor |
7.206e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
PMID: 18234675 |
| HSC(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
PILRA_receptor |
6.265e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
PMID: 18234675 |
| Monocytes(Nos)_source |
CD99_ligand |
Monocytes(Nos)_target |
PILRA_receptor |
8.105e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
PMID: 18234675 |
| CD8+,T-cells(Nos)_source |
CD99_ligand |
CD8+,T-cells(Nos)_target |
CD99_receptor |
7.912e-03 |
0.04 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
CD99_ligand |
CD8+,T-cells(Nos)_target |
CD99_receptor |
6.769e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
6.769e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
CD99_ligand |
HSC(Nos)_target |
CD99_receptor |
5.748e-03 |
0.0 |
CD99 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ICAM1_ligand |
Monocytes(Nos)_target |
ITGAX_ITGB2_receptor |
3.027e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 16252253 |
| Monocytes(Nos)_source |
ICAM1_ligand |
Monocytes(Nos)_target |
ITGAL_ITGB2_receptor |
2.103e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
CD8+,T-cells(Nos)_target |
ITGAL_ITGB2_receptor |
5.937e-05 |
0.01 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
HSC(Nos)_target |
ITGAL_ITGB2_receptor |
2.668e-05 |
0.01 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ICAM2_ligand |
Monocytes(Nos)_target |
ITGAL_ITGB2_receptor |
3.429e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ICAM1_ligand |
CD8+,T-cells(Nos)_target |
SPN_receptor |
4.140e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| CD8+,T-cells(Nos)_source |
ICAM1_ligand |
HSC(Nos)_target |
SPN_receptor |
1.802e-04 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| HSC(Nos)_source |
ICAM1_ligand |
HSC(Nos)_target |
SPN_receptor |
7.643e-05 |
0.04 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| Monocytes(Nos)_source |
ICAM1_ligand |
HSC(Nos)_target |
SPN_receptor |
1.362e-03 |
0.0 |
ICAM |
Cell-Cell Contact |
PMID: 1683685 |
| Monocytes(Nos)_source |
ITGB2_ligand |
Monocytes(Nos)_target |
ICAM1_receptor |
2.953e-03 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
ICAM2_receptor |
4.140e-05 |
0.01 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
ICAM2_receptor |
3.062e-05 |
0.01 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
ITGB2_ligand |
HSC(Nos)_target |
ICAM2_receptor |
4.824e-04 |
0.0 |
ITGB2 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
F11R_ligand |
CD8+,T-cells(Nos)_target |
ITGAL_ITGB2_receptor |
5.948e-05 |
0.0 |
JAM |
Cell-Cell Contact |
PMID: 11812992 |
| HSC(Nos)_source |
F11R_ligand |
HSC(Nos)_target |
ITGAL_ITGB2_receptor |
2.672e-05 |
0.02 |
JAM |
Cell-Cell Contact |
PMID: 11812992 |
| HSC(Nos)_source |
F11R_ligand |
Monocytes(Nos)_target |
ITGAL_ITGB2_receptor |
3.435e-04 |
0.0 |
JAM |
Cell-Cell Contact |
PMID: 11812992 |
| HSC(Nos)_source |
F11R_ligand |
HSC(Nos)_target |
F11R_receptor |
4.663e-05 |
0.0 |
JAM |
Cell-Cell Contact |
KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source |
HLA-F_ligand |
Monocytes(Nos)_target |
LILRB1_receptor |
4.149e-04 |
0.0 |
MHC-I |
Cell-Cell Contact |
PMID: 28484462 |
| HSC(Nos)_source |
MPZL1_ligand |
HSC(Nos)_target |
MPZL1_receptor |
8.706e-06 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| Monocytes(Nos)_source |
MPZL1_ligand |
HSC(Nos)_target |
MPZL1_receptor |
1.564e-06 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
MPZL1_ligand |
Monocytes(Nos)_target |
MPZL1_receptor |
1.564e-06 |
0.0 |
MPZ |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
PECAM1_ligand |
HSC(Nos)_target |
PECAM1_receptor |
5.111e-05 |
0.01 |
PECAM1 |
Cell-Cell Contact |
KEGG: hsa04514 |
| HSC(Nos)_source |
SELL_ligand |
HSC(Nos)_target |
CD34_receptor |
1.726e-04 |
0.0 |
SELL |
Cell-Cell Contact |
PMID: 7692600; PMID: 8977216 |
| Monocytes(Nos)_source |
SEMA4A_ligand |
HSC(Nos)_target |
PLXNB2_receptor |
6.289e-05 |
0.02 |
SEMA4 |
Cell-Cell Contact |
PMID: 27533782 |
| HSC(Nos)_source |
SEMA4A_ligand |
Monocytes(Nos)_target |
PLXNB2_receptor |
8.213e-05 |
0.0 |
SEMA4 |
Cell-Cell Contact |
PMID: 27533782 |
| Monocytes(Nos)_source |
SEMA4A_ligand |
Monocytes(Nos)_target |
PLXNB2_receptor |
2.561e-04 |
0.0 |
SEMA4 |
Cell-Cell Contact |
PMID: 27533782 |