Sample overview

Project Name	Kidney Renal Clear Cell Carcinoma
GSE ID	GSE223808
GSM ID	GSM6996168
Cell Line	None
Tissue type	Kidney
Disease Type	Renal cell carcinoma
PMID	36928415
Initial gene number	33538
Initial cell number	8854
Post-QC gene number	7196
Post-QC cell number	7810

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Nos)_source	CCL4_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	4.292e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Good)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	4.532e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	6.588e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL3_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	1.471e-02	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Good)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	2.534e-04	0.01	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	3.711e-03	0.01	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	3.320e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	4.702e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CD44_receptor	2.670e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	3.927e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Poor)_target	CD74_CD44_receptor	2.773e-04	0.01	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	1.109e-04	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Poor)_target	TNFRSF1A_receptor	9.096e-06	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF14_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.293e-03	0.0	LIGHT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Poor)_source	TNFSF10_ligand	CD8+,T-cells(Nos)_target	TNFRSF10A_receptor	8.405e-06	0.03	TRAIL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Poor)_source	CD70_ligand	CD8+,T-cells(Good)_target	CD27_receptor	3.382e-05	0.0	CD70	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Poor)_source	CD70_ligand	CD8+,T-cells(Nos)_target	CD27_receptor	5.420e-04	0.0	CD70	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Poor)_source	CD70_ligand	CD8+,T-cells(Poor)_target	CD27_receptor	2.951e-05	0.01	CD70	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Poor)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.054e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Poor)_target	CD99_receptor	1.054e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Poor)_source	CD99_ligand	CD8+,T-cells(Poor)_target	CD99_receptor	8.676e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	ITGB2_ligand	CD8+,T-cells(Nos)_target	ICAM1_receptor	6.189e-04	0.03	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	5.233e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	7.627e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	7.479e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.090e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	5.709e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	8.189e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	8.163e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.171e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	5.735e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	8.061e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	8.201e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.152e-01	0.04	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	7.350e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	1.028e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.053e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	1.472e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-F_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	3.215e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Good)_target	CD8A_receptor	4.463e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	4.585e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8A_receptor	6.364e-02	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	6.768e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	9.869e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Poor)_source	HLA-A_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	7.409e-04	0.03	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	9.348e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-A_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.363e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	7.349e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	1.056e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.016e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-B_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.459e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	7.381e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	1.040e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.021e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-C_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.437e-01	0.01	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	9.312e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	1.308e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.293e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	1.814e-01	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-F_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	4.242e-04	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Good)_target	CD8B_receptor	5.899e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	5.826e-03	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-F_ligand	CD8+,T-cells(Nos)_target	CD8B_receptor	8.099e-02	0.0	MHC-I	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Poor)_target	KLRC1_receptor	3.941e-05	0.03	MHC-I	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Poor)_target	KLRC1_receptor	5.444e-04	0.04	MHC-I	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Good)_source	HLA-E_ligand	CD8+,T-cells(Poor)_target	CD94:NKG2A_receptor	4.550e-05	0.02	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Nos)_source	HLA-E_ligand	CD8+,T-cells(Poor)_target	CD94:NKG2A_receptor	6.288e-04	0.04	MHC-I	Cell-Cell Contact	PMID: 28484462
CD8+,T-cells(Good)_source	PECAM1_ligand	CD8+,T-cells(Good)_target	PECAM1_receptor	7.540e-06	0.01	PECAM1	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGA4_ITGB1_ligand	CD8+,T-cells(Nos)_target	VCAM1_receptor	8.793e-03	0.0	VCAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGA4_ITGB7_ligand	CD8+,T-cells(Nos)_target	VCAM1_receptor	7.845e-03	0.0	VCAM	Cell-Cell Contact	KEGG: hsa04514