Sample overview

Project Name	TCGA-KIRC
GSE ID	GSE223808
GSM ID	GSM6996167
Cell Line	None
Tissue type	Kidney
Disease Type	Renal cell carcinoma
PMID	36928415
Initial gene number	33538
Initial cell number	7650
Post-QC gene number	6433
Post-QC cell number	7004

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Nos)_source	CCL4_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	7.642e-04	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	CCL5_ligand	CD8+,T-cells(Nos)_target	CCR5_receptor	8.482e-03	0.0	CCL	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	3.622e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CXCR4_receptor	3.032e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	3.549e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Poor)_target	CD74_CXCR4_receptor	2.489e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CD44_receptor	3.623e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Good)_target	CD74_CD44_receptor	3.032e-04	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Poor)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	3.378e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	3.217e-04	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Poor)_source	LGALS9_ligand	CD8+,T-cells(Good)_target	PTPRC_receptor	4.727e-05	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
CD8+,T-cells(Poor)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	PTPRC_receptor	5.893e-04	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
CD8+,T-cells(Poor)_source	LGALS9_ligand	CD8+,T-cells(Poor)_target	PTPRC_receptor	3.707e-05	0.0	GALECTIN	Secreted Signaling	PMID: 30120235
CD8+,T-cells(Poor)_source	LGALS9_ligand	CD8+,T-cells(Good)_target	CD44_receptor	2.051e-05	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
CD8+,T-cells(Poor)_source	LGALS9_ligand	CD8+,T-cells(Nos)_target	CD44_receptor	2.021e-04	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
CD8+,T-cells(Poor)_source	LGALS9_ligand	CD8+,T-cells(Poor)_target	CD44_receptor	1.283e-05	0.0	GALECTIN	Secreted Signaling	PMID: 25065622
CD8+,T-cells(Poor)_source	APP_ligand	CD8+,T-cells(Good)_target	CD74_receptor	2.872e-06	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Poor)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	3.550e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Nos)_source	APP_ligand	CD8+,T-cells(Poor)_target	CD74_receptor	2.808e-05	0.02	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Poor)_source	APP_ligand	CD8+,T-cells(Poor)_target	CD74_receptor	2.738e-06	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Poor)_source	CD99_ligand	CD8+,T-cells(Good)_target	CD99_receptor	6.519e-04	0.02	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Poor)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	8.394e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	CD99_ligand	CD8+,T-cells(Poor)_target	CD99_receptor	6.519e-04	0.02	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Poor)_target	CD99_receptor	8.394e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Poor)_source	CD99_ligand	CD8+,T-cells(Poor)_target	CD99_receptor	6.450e-04	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Poor)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.852e-04	0.01	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	ICAM2_ligand	CD8+,T-cells(Good)_target	ITGAL_ITGB2_receptor	9.855e-06	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	ICAM2_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.772e-04	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Good)_source	ICAM2_ligand	CD8+,T-cells(Poor)_target	ITGAL_ITGB2_receptor	1.448e-05	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Poor)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	SPN_receptor	1.360e-08	0.02	ICAM	Cell-Cell Contact	PMID: 1683685
CD8+,T-cells(Good)_source	ICAM1_ligand	CD8+,T-cells(Poor)_target	SPN_receptor	3.721e-06	0.01	ICAM	Cell-Cell Contact	PMID: 1683685
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Poor)_target	SPN_receptor	5.332e-05	0.0	ICAM	Cell-Cell Contact	PMID: 1683685
CD8+,T-cells(Poor)_source	ICAM1_ligand	CD8+,T-cells(Poor)_target	SPN_receptor	4.076e-06	0.0	ICAM	Cell-Cell Contact	PMID: 1683685