Sample overview
| Project Name | TCGA-HNSC |
| GSE ID | GSE164690 |
| GSM ID | GSM5017062 |
| Cell Line | None |
| Tissue type | Tumor |
| Disease Type | None |
| PMID | 34921143 |
| Initial gene number | 33545 |
| Initial cell number | 2673 |
| Post-QC gene number | 1830 |
| Post-QC cell number | 2267 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Adipocytes(Nos)_source | MIF_ligand | Endothelial,cells(Nos)_target | ACKR3_receptor | 8.486e-08 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Endothelial,cells(Nos)_target | ACKR3_receptor | 1.218e-04 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Endothelial,cells(Nos)_source | MIF_ligand | Endothelial,cells(Nos)_target | ACKR3_receptor | 9.718e-04 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Fibroblasts(Nos)_source | MIF_ligand | Endothelial,cells(Nos)_target | ACKR3_receptor | 3.662e-04 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Keratinocytes(Nos)_source | MIF_ligand | Endothelial,cells(Nos)_target | ACKR3_receptor | 2.183e-04 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Adipocytes(Nos)_source | MIF_ligand | Fibroblasts(Nos)_target | ACKR3_receptor | 1.714e-08 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Fibroblasts(Nos)_target | ACKR3_receptor | 2.486e-05 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Endothelial,cells(Nos)_source | MIF_ligand | Fibroblasts(Nos)_target | ACKR3_receptor | 1.994e-04 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Fibroblasts(Nos)_source | MIF_ligand | Fibroblasts(Nos)_target | ACKR3_receptor | 7.498e-05 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Keratinocytes(Nos)_source | MIF_ligand | Fibroblasts(Nos)_target | ACKR3_receptor | 4.473e-05 | 0.0 | MIF | Secreted Signaling | PMID: 26175090 |
| Endothelial,cells(Nos)_source | NAMPT_ligand | CD8+,T-cells(Nos)_target | ITGA5_ITGB1_receptor | 2.531e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Fibroblasts(Nos)_source | NAMPT_ligand | CD8+,T-cells(Nos)_target | ITGA5_ITGB1_receptor | 1.384e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| CD8+,T-cells(Nos)_source | NAMPT_ligand | Endothelial,cells(Nos)_target | ITGA5_ITGB1_receptor | 8.896e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Endothelial,cells(Nos)_source | NAMPT_ligand | Endothelial,cells(Nos)_target | ITGA5_ITGB1_receptor | 1.138e-03 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Fibroblasts(Nos)_source | NAMPT_ligand | Endothelial,cells(Nos)_target | ITGA5_ITGB1_receptor | 6.175e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| CD8+,T-cells(Nos)_source | NAMPT_ligand | Fibroblasts(Nos)_target | ITGA5_ITGB1_receptor | 3.432e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Endothelial,cells(Nos)_source | NAMPT_ligand | Fibroblasts(Nos)_target | ITGA5_ITGB1_receptor | 4.401e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Fibroblasts(Nos)_source | NAMPT_ligand | Fibroblasts(Nos)_target | ITGA5_ITGB1_receptor | 2.390e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Endothelial,cells(Nos)_source | NAMPT_ligand | Keratinocytes(Nos)_target | ITGA5_ITGB1_receptor | 3.539e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Fibroblasts(Nos)_source | NAMPT_ligand | Keratinocytes(Nos)_target | ITGA5_ITGB1_receptor | 1.934e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Endothelial,cells(Nos)_source | ANGPTL2_ligand | Adipocytes(Nos)_target | ITGA5_ITGB1_receptor | 8.630e-09 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Fibroblasts(Nos)_source | ANGPTL2_ligand | Adipocytes(Nos)_target | ITGA5_ITGB1_receptor | 3.358e-08 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Endothelial,cells(Nos)_source | ANGPTL2_ligand | CD8+,T-cells(Nos)_target | ITGA5_ITGB1_receptor | 3.763e-06 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Fibroblasts(Nos)_source | ANGPTL2_ligand | CD8+,T-cells(Nos)_target | ITGA5_ITGB1_receptor | 1.457e-05 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Endothelial,cells(Nos)_source | ANGPTL2_ligand | Endothelial,cells(Nos)_target | ITGA5_ITGB1_receptor | 1.736e-04 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Fibroblasts(Nos)_source | ANGPTL2_ligand | Endothelial,cells(Nos)_target | ITGA5_ITGB1_receptor | 6.491e-04 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Endothelial,cells(Nos)_source | ANGPTL2_ligand | Fibroblasts(Nos)_target | ITGA5_ITGB1_receptor | 6.689e-05 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Fibroblasts(Nos)_source | ANGPTL2_ligand | Fibroblasts(Nos)_target | ITGA5_ITGB1_receptor | 2.513e-04 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Endothelial,cells(Nos)_source | ANGPTL2_ligand | Keratinocytes(Nos)_target | ITGA5_ITGB1_receptor | 5.261e-06 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Fibroblasts(Nos)_source | ANGPTL2_ligand | Keratinocytes(Nos)_target | ITGA5_ITGB1_receptor | 2.037e-05 | 0.0 | ANGPTL | Secreted Signaling | PMID: 24478758 |
| Endothelial,cells(Nos)_source | MDK_ligand | CD8+,T-cells(Nos)_target | NCL_receptor | 2.081e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Fibroblasts(Nos)_source | MDK_ligand | CD8+,T-cells(Nos)_target | NCL_receptor | 5.851e-05 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Endothelial,cells(Nos)_source | MDK_ligand | Endothelial,cells(Nos)_target | NCL_receptor | 1.362e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Fibroblasts(Nos)_source | MDK_ligand | Endothelial,cells(Nos)_target | NCL_receptor | 3.840e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Endothelial,cells(Nos)_source | MDK_ligand | Fibroblasts(Nos)_target | NCL_receptor | 5.076e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Fibroblasts(Nos)_source | MDK_ligand | Fibroblasts(Nos)_target | NCL_receptor | 1.428e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Endothelial,cells(Nos)_source | MDK_ligand | Keratinocytes(Nos)_target | NCL_receptor | 1.060e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Fibroblasts(Nos)_source | MDK_ligand | Keratinocytes(Nos)_target | NCL_receptor | 2.959e-05 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Endothelial,cells(Nos)_source | FN1_ligand | CD8+,T-cells(Nos)_target | ITGA5_ITGB1_receptor | 1.679e-05 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | FN1_ligand | CD8+,T-cells(Nos)_target | ITGA5_ITGB1_receptor | 9.769e-06 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | FN1_ligand | Endothelial,cells(Nos)_target | ITGA5_ITGB1_receptor | 7.626e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | FN1_ligand | Endothelial,cells(Nos)_target | ITGA5_ITGB1_receptor | 4.407e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | FN1_ligand | Fibroblasts(Nos)_target | ITGA5_ITGB1_receptor | 2.945e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | FN1_ligand | Fibroblasts(Nos)_target | ITGA5_ITGB1_receptor | 1.703e-04 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | FN1_ligand | Keratinocytes(Nos)_target | ITGA5_ITGB1_receptor | 2.347e-05 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | FN1_ligand | Keratinocytes(Nos)_target | ITGA5_ITGB1_receptor | 1.366e-05 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | THBS1_ligand | CD8+,T-cells(Nos)_target | CD47_receptor | 1.346e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | THBS1_ligand | CD8+,T-cells(Nos)_target | CD47_receptor | 1.404e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | THBS1_ligand | Endothelial,cells(Nos)_target | CD47_receptor | 2.482e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | THBS1_ligand | Endothelial,cells(Nos)_target | CD47_receptor | 2.572e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Keratinocytes(Nos)_source | THBS1_ligand | Endothelial,cells(Nos)_target | CD47_receptor | 1.605e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | THBS1_ligand | Fibroblasts(Nos)_target | CD47_receptor | 7.115e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | THBS1_ligand | Fibroblasts(Nos)_target | CD47_receptor | 7.397e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Keratinocytes(Nos)_source | THBS1_ligand | Fibroblasts(Nos)_target | CD47_receptor | 4.589e-07 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | THBS1_ligand | Keratinocytes(Nos)_target | CD47_receptor | 1.594e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Fibroblasts(Nos)_source | THBS1_ligand | Keratinocytes(Nos)_target | CD47_receptor | 1.664e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Endothelial,cells(Nos)_source | APP_ligand | CD8+,T-cells(Nos)_target | CD74_receptor | 5.351e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Fibroblasts(Nos)_source | APP_ligand | CD8+,T-cells(Nos)_target | CD74_receptor | 1.667e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Keratinocytes(Nos)_source | APP_ligand | CD8+,T-cells(Nos)_target | CD74_receptor | 1.311e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Endothelial,cells(Nos)_source | APP_ligand | Endothelial,cells(Nos)_target | CD74_receptor | 1.704e-03 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Fibroblasts(Nos)_source | APP_ligand | Endothelial,cells(Nos)_target | CD74_receptor | 5.253e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Keratinocytes(Nos)_source | APP_ligand | Endothelial,cells(Nos)_target | CD74_receptor | 4.039e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Endothelial,cells(Nos)_source | APP_ligand | Fibroblasts(Nos)_target | CD74_receptor | 6.312e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Fibroblasts(Nos)_source | APP_ligand | Fibroblasts(Nos)_target | CD74_receptor | 1.942e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Keratinocytes(Nos)_source | APP_ligand | Fibroblasts(Nos)_target | CD74_receptor | 1.486e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Endothelial,cells(Nos)_source | APP_ligand | Keratinocytes(Nos)_target | CD74_receptor | 1.768e-04 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Fibroblasts(Nos)_source | APP_ligand | Keratinocytes(Nos)_target | CD74_receptor | 5.404e-05 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 6.833e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 6.774e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.353e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Keratinocytes(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.821e-05 | 0.01 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | Endothelial,cells(Nos)_target | CD99_receptor | 6.774e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CD99_ligand | Endothelial,cells(Nos)_target | CD99_receptor | 6.433e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CD99_ligand | Endothelial,cells(Nos)_target | CD99_receptor | 2.277e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Keratinocytes(Nos)_source | CD99_ligand | Endothelial,cells(Nos)_target | CD99_receptor | 2.900e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | Fibroblasts(Nos)_target | CD99_receptor | 2.353e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CD99_ligand | Fibroblasts(Nos)_target | CD99_receptor | 2.277e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CD99_ligand | Fibroblasts(Nos)_target | CD99_receptor | 7.995e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Keratinocytes(Nos)_source | CD99_ligand | Fibroblasts(Nos)_target | CD99_receptor | 9.916e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | Keratinocytes(Nos)_target | CD99_receptor | 2.821e-05 | 0.01 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CD99_ligand | Keratinocytes(Nos)_target | CD99_receptor | 2.900e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CD99_ligand | Keratinocytes(Nos)_target | CD99_receptor | 9.916e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CDH5_ligand | Adipocytes(Nos)_target | CDH5_receptor | 5.224e-09 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CDH5_ligand | CD8+,T-cells(Nos)_target | CDH5_receptor | 1.276e-08 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CDH5_ligand | CD8+,T-cells(Nos)_target | CDH5_receptor | 8.740e-12 | 0.03 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CDH5_ligand | Endothelial,cells(Nos)_target | CDH5_receptor | 5.224e-09 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CDH5_ligand | Endothelial,cells(Nos)_target | CDH5_receptor | 1.276e-08 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CDH5_ligand | Endothelial,cells(Nos)_target | CDH5_receptor | 2.638e-04 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CDH5_ligand | Endothelial,cells(Nos)_target | CDH5_receptor | 1.821e-07 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Keratinocytes(Nos)_source | CDH5_ligand | Endothelial,cells(Nos)_target | CDH5_receptor | 2.383e-08 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CDH5_ligand | Fibroblasts(Nos)_target | CDH5_receptor | 8.740e-12 | 0.03 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CDH5_ligand | Fibroblasts(Nos)_target | CDH5_receptor | 1.821e-07 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CDH5_ligand | Fibroblasts(Nos)_target | CDH5_receptor | 1.248e-10 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Keratinocytes(Nos)_source | CDH5_ligand | Fibroblasts(Nos)_target | CDH5_receptor | 1.632e-11 | 0.03 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | CDH5_ligand | Keratinocytes(Nos)_target | CDH5_receptor | 2.383e-08 | 0.0 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Fibroblasts(Nos)_source | CDH5_ligand | Keratinocytes(Nos)_target | CDH5_receptor | 1.632e-11 | 0.03 | CDH5 | Cell-Cell Contact | KEGG: hsa04514 |
| Endothelial,cells(Nos)_source | PECAM1_ligand | Endothelial,cells(Nos)_target | PECAM1_receptor | 2.258e-03 | 0.0 | PECAM1 | Cell-Cell Contact | KEGG: hsa04514 |