Sample overview
| Project Name | TCGA-HNSC |
| GSE ID | GSE164690 |
| GSM ID | GSM5017060 |
| Cell Line | None |
| Tissue type | PBL |
| Disease Type | None |
| PMID | 34921143 |
| Initial gene number | 33545 |
| Initial cell number | 1821 |
| Post-QC gene number | 1146 |
| Post-QC cell number | 1165 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| B-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 4.239e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 4.458e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 2.740e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Good)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 2.445e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 2.737e-04 | 0.01 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 1.207e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 1.929e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 1.182e-04 | 0.02 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 5.257e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| B-cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CXCR4_receptor | 1.958e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CXCR4_receptor | 2.064e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CXCR4_receptor | 1.267e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Good)_source | MIF_ligand | Monocytes(Good)_target | CD74_CXCR4_receptor | 1.130e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CXCR4_receptor | 5.604e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| B-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 2.635e-04 | 0.03 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 2.782e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 1.706e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Good)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 1.522e-04 | 0.01 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 7.568e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CXCR4_receptor | 5.082e-03 | 0.02 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| NK,cells(Nos)_source | MIF_ligand | NK,cells(Nos)_target | CD74_CXCR4_receptor | 1.390e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| B-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 2.569e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 2.721e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 1.666e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Good)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 1.486e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 7.440e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | CD4+,T-cells(Nos)_target | CD74_CD44_receptor | 3.322e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 1.250e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 7.645e-05 | 0.04 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 3.431e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| B-cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CD44_receptor | 1.558e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CD44_receptor | 1.648e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CD44_receptor | 1.010e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Good)_source | MIF_ligand | Monocytes(Good)_target | CD74_CD44_receptor | 9.010e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CD44_receptor | 1.002e-04 | 0.03 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | Monocytes(Good)_target | CD74_CD44_receptor | 4.496e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| B-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 2.335e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 2.469e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 1.513e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Good)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 1.350e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 1.501e-04 | 0.01 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| NK,cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 6.733e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 1.391e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Good)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 9.895e-06 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 5.353e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| NK,cells(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 5.528e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | Monocytes(Good)_target | CD55_receptor | 6.741e-06 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | ADGRE5_ligand | Monocytes(Good)_target | CD55_receptor | 2.596e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| NK,cells(Nos)_source | ADGRE5_ligand | Monocytes(Good)_target | CD55_receptor | 2.679e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 2.548e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Good)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 1.815e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Monocytes(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 9.692e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| NK,cells(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 1.011e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD4+,T-cells(Nos)_target | CD99_receptor | 2.620e-03 | 0.01 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | CD4+,T-cells(Nos)_target | CD99_receptor | 1.121e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.620e-03 | 0.01 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.710e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Good)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 1.580e-04 | 0.03 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.192e-04 | 0.02 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 1.138e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | Monocytes(Good)_target | CD99_receptor | 1.580e-04 | 0.03 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | Monocytes(Good)_target | CD99_receptor | 6.762e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 2.192e-04 | 0.02 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 9.398e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 1.121e-02 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 1.138e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Good)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 6.762e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 9.398e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 4.705e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| B-cells(Nos)_source | CLEC2D_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 1.454e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CLEC2D_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 1.179e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| B-cells(Nos)_source | CLEC2D_ligand | NK,cells(Nos)_target | KLRB1_receptor | 6.849e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CLEC2D_ligand | NK,cells(Nos)_target | KLRB1_receptor | 5.562e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 8.106e-05 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Monocytes(Good)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 4.369e-05 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Monocytes(Nos)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 1.852e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 3.290e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 3.824e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Monocytes(Good)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 2.079e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Monocytes(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 8.602e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.543e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| B-cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 6.635e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 3.726e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 2.784e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 8.144e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| B-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 2.893e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.682e-02 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 1.248e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 3.675e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |