Sample overview
| Project Name | TCGA-HNSC |
| GSE ID | GSE164690 |
| GSM ID | GSM5017032 |
| Cell Line | None |
| Tissue type | Tumor |
| Disease Type | None |
| PMID | 34921143 |
| Initial gene number | 33545 |
| Initial cell number | 3226 |
| Post-QC gene number | 1904 |
| Post-QC cell number | 2113 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Monocytes(Nos)_source | MIF_ligand | Adipocytes(Nos)_target | CD74_CXCR4_receptor | 9.365e-05 | 0.02 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Adipocytes(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 4.954e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| B-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 8.389e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 5.277e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 1.400e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CXCR4_receptor | 7.608e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Adipocytes(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 3.600e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CXCR4_receptor | 5.493e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Adipocytes(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 1.854e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| B-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 3.106e-04 | 0.02 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD4+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 1.952e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 5.188e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Monocytes(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 2.837e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Adipocytes(Nos)_source | MIF_ligand | Adipocytes(Nos)_target | CD74_CD44_receptor | 8.374e-06 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | MIF_ligand | Adipocytes(Nos)_target | CD74_CD44_receptor | 1.280e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Adipocytes(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 3.399e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| B-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 5.691e-05 | 0.02 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 3.578e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 9.508e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | MIF_ligand | B-cells(Nos)_target | CD74_CD44_receptor | 5.200e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Adipocytes(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 3.354e-05 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | MIF_ligand | CD8+,T-cells(Nos)_target | CD74_CD44_receptor | 5.117e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Adipocytes(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 2.001e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| B-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 3.358e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD4+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 2.111e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| CD8+,T-cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 5.609e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 3.063e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Adipocytes(Nos)_source | NAMPT_ligand | Adipocytes(Nos)_target | ITGA5_ITGB1_receptor | 8.275e-06 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | Adipocytes(Nos)_target | ITGA5_ITGB1_receptor | 2.114e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | CD8+,T-cells(Nos)_target | ITGA5_ITGB1_receptor | 2.878e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Adipocytes(Nos)_source | NAMPT_ligand | Monocytes(Nos)_target | ITGA5_ITGB1_receptor | 2.285e-05 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | Monocytes(Nos)_target | ITGA5_ITGB1_receptor | 5.914e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Adipocytes(Nos)_source | NAMPT_ligand | NK,cells(Nos)_target | ITGA5_ITGB1_receptor | 6.261e-06 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | NK,cells(Nos)_target | ITGA5_ITGB1_receptor | 1.623e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Adipocytes(Nos)_source | THBS1_ligand | Adipocytes(Nos)_target | CD47_receptor | 2.248e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| B-cells(Nos)_source | THBS1_ligand | Adipocytes(Nos)_target | CD47_receptor | 1.129e-08 | 0.01 | THBS | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | THBS1_ligand | Adipocytes(Nos)_target | CD47_receptor | 9.553e-08 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| CD8+,T-cells(Nos)_source | THBS1_ligand | Adipocytes(Nos)_target | CD47_receptor | 5.038e-08 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Adipocytes(Nos)_target | CD47_receptor | 5.500e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| NK,cells(Nos)_source | THBS1_ligand | Adipocytes(Nos)_target | CD47_receptor | 1.343e-07 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Adipocytes(Nos)_source | THBS1_ligand | B-cells(Nos)_target | CD47_receptor | 2.221e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| CD8+,T-cells(Nos)_source | THBS1_ligand | B-cells(Nos)_target | CD47_receptor | 4.941e-08 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | B-cells(Nos)_target | CD47_receptor | 5.448e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| NK,cells(Nos)_source | THBS1_ligand | B-cells(Nos)_target | CD47_receptor | 1.318e-07 | 0.02 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Adipocytes(Nos)_source | THBS1_ligand | CD4+,T-cells(Nos)_target | CD47_receptor | 1.442e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| CD8+,T-cells(Nos)_source | THBS1_ligand | CD4+,T-cells(Nos)_target | CD47_receptor | 3.209e-07 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | CD4+,T-cells(Nos)_target | CD47_receptor | 3.538e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| NK,cells(Nos)_source | THBS1_ligand | CD4+,T-cells(Nos)_target | CD47_receptor | 8.557e-07 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | CD8+,T-cells(Nos)_target | CD47_receptor | 4.665e-06 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Monocytes(Nos)_target | CD47_receptor | 4.593e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | NK,cells(Nos)_target | CD47_receptor | 2.643e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Adipocytes(Nos)_source | ADGRE5_ligand | Adipocytes(Nos)_target | CD55_receptor | 6.968e-07 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | Adipocytes(Nos)_target | CD55_receptor | 5.785e-06 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| NK,cells(Nos)_source | ADGRE5_ligand | Adipocytes(Nos)_target | CD55_receptor | 1.978e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 9.852e-06 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| NK,cells(Nos)_source | ADGRE5_ligand | B-cells(Nos)_target | CD55_receptor | 3.369e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Adipocytes(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 7.113e-06 | 0.02 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| CD8+,T-cells(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 5.911e-05 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| NK,cells(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 2.021e-04 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Adipocytes(Nos)_source | CD99_ligand | Adipocytes(Nos)_target | CD99_receptor | 2.695e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CD99_ligand | Adipocytes(Nos)_target | CD99_receptor | 1.077e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | Adipocytes(Nos)_target | CD99_receptor | 9.045e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | CD99_ligand | Adipocytes(Nos)_target | CD99_receptor | 9.903e-05 | 0.02 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | Adipocytes(Nos)_target | CD99_receptor | 3.571e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CD99_ligand | CD4+,T-cells(Nos)_target | CD99_receptor | 1.077e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | CD4+,T-cells(Nos)_target | CD99_receptor | 1.391e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 9.045e-05 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 2.979e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | CD8+,T-cells(Nos)_target | CD99_receptor | 1.185e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 9.903e-05 | 0.02 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 1.279e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 3.571e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 1.391e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD8+,T-cells(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 1.185e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 1.279e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| NK,cells(Nos)_source | CD99_ligand | NK,cells(Nos)_target | CD99_receptor | 4.699e-03 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CLEC2D_ligand | CD4+,T-cells(Nos)_target | KLRB1_receptor | 4.767e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CLEC2D_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 2.474e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CLEC2D_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 5.911e-05 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CLEC2D_ligand | NK,cells(Nos)_target | KLRB1_receptor | 2.241e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CLEC2D_ligand | NK,cells(Nos)_target | KLRB1_receptor | 5.352e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Adipocytes(Nos)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 3.745e-05 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Monocytes(Nos)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 6.175e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CLEC2B_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 7.626e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Adipocytes(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 3.254e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 2.112e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 6.012e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| Monocytes(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 5.398e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CLEC2B_ligand | NK,cells(Nos)_target | KLRB1_receptor | 6.552e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CD69_ligand | CD4+,T-cells(Nos)_target | KLRB1_receptor | 1.348e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| B-cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 4.375e-05 | 0.01 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 6.929e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 6.690e-05 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CD69_ligand | CD8+,T-cells(Nos)_target | KLRB1_receptor | 2.361e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| B-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 3.951e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD4+,T-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 6.087e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| CD8+,T-cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 6.043e-04 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |
| NK,cells(Nos)_source | CD69_ligand | NK,cells(Nos)_target | KLRB1_receptor | 2.128e-03 | 0.0 | CLEC | Cell-Cell Contact | PMID: 24223577 |