Sample overview

Project Name	TCGA-DLBC
GSE ID	GSE242756
GSM ID	GSM7770084
Cell Line	None
Tissue type	lymph nodes
Disease Type	None
PMID	37695745
Initial gene number	33549
Initial cell number	9262
Post-QC gene number	7437
Post-QC cell number	6094

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD8+,T-cells(Nos)_source	MIF_ligand	CD4+,T-cells(Nos)_target	CD74_CXCR4_receptor	1.090e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD4+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	1.045e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	4.269e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	IL21_ligand	CD8+,T-cells(Nos)_target	IL21R_IL2RG_receptor	6.905e-05	0.0	IL2	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	IL16_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	6.603e-03	0.0	IL16	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	IL16_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	2.439e-03	0.0	IL16	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	CD4+,T-cells(Nos)_target	TNFRSF1A_receptor	5.067e-05	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	2.635e-05	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	CD4+,T-cells(Nos)_target	TNFRSF1B_receptor	2.765e-04	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	5.825e-04	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	1.059e-04	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	4.583e-05	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	2.333e-03	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	1.008e-03	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	2.061e-03	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	8.903e-04	0.0	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	CD40LG_ligand	CD4+,T-cells(Nos)_target	ITGA5_ITGB1_receptor	3.774e-04	0.01	CD40	Secreted Signaling	PMID: 28676852
CD4+,T-cells(Nos)_source	CD40LG_ligand	CD8+,T-cells(Nos)_target	ITGA5_ITGB1_receptor	1.655e-04	0.0	CD40	Secreted Signaling	PMID: 28676852
CD8+,T-cells(Nos)_source	NAMPT_ligand	CD4+,T-cells(Nos)_target	ITGA5_ITGB1_receptor	1.755e-04	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
CD8+,T-cells(Nos)_source	NAMPT_ligand	CD8+,T-cells(Nos)_target	ITGA5_ITGB1_receptor	7.699e-05	0.0	VISFATIN	Secreted Signaling	PMID: 28490838
CD4+,T-cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.292e-03	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	5.618e-04	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD4+,T-cells(Nos)_source	ADGRE5_ligand	CD4+,T-cells(Nos)_target	CD55_receptor	1.399e-03	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
CD8+,T-cells(Nos)_source	ADGRE5_ligand	CD4+,T-cells(Nos)_target	CD55_receptor	5.643e-04	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
CD4+,T-cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	1.027e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	3.467e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Nos)_source	CD99_ligand	CD4+,T-cells(Nos)_target	CD99_receptor	1.309e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.309e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	5.664e-03	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	ICAM2_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.465e-03	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGB2_ligand	CD4+,T-cells(Nos)_target	ICAM2_receptor	2.974e-03	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPA1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	2.397e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPA1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	2.091e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.101e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	9.687e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DMA_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	7.292e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DMA_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	6.431e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.929e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	1.687e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	8.631e-03	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607
CD8+,T-cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	5.422e-03	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607