Sample overview

Project Name	TCGA-DLBC
GSE ID	GSE242756
GSM ID	GSM7770082
Cell Line	None
Tissue type	lymph nodes
Disease Type	None
PMID	37695745
Initial gene number	33549
Initial cell number	7849
Post-QC gene number	7518
Post-QC cell number	5829

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
CD4+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	1.460e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	8.126e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD4+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	1.200e-02	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	6.685e-03	0.0	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	IL21_ligand	CD8+,T-cells(Nos)_target	IL21R_IL2RG_receptor	1.111e-04	0.0	IL2	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	IL16_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	5.444e-03	0.0	IL16	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	IL16_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	3.120e-03	0.0	IL16	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	3.100e-05	0.03	TNF	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	TNF_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	6.267e-04	0.0	TNF	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF14_ligand	CD4+,T-cells(Nos)_target	TNFRSF14_receptor	7.515e-04	0.0	LIGHT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	TNFSF14_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	4.162e-04	0.0	LIGHT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	GZMA_ligand	CD4+,T-cells(Nos)_target	F2R_receptor	1.007e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD8+,T-cells(Nos)_source	GZMA_ligand	CD8+,T-cells(Nos)_target	F2R_receptor	7.423e-08	0.0	PARs	Secreted Signaling	KEGG: hsa04080
CD8+,T-cells(Nos)_source	BTLA_ligand	CD4+,T-cells(Nos)_target	TNFRSF14_receptor	1.686e-03	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	9.337e-04	0.0	BTLA	Secreted Signaling	PMID: 21941365
CD4+,T-cells(Nos)_source	ADGRE5_ligand	CD4+,T-cells(Nos)_target	CD55_receptor	1.015e-03	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
CD8+,T-cells(Nos)_source	ADGRE5_ligand	CD4+,T-cells(Nos)_target	CD55_receptor	5.252e-04	0.0	ADGRE5	Cell-Cell Contact	PMID: 11297558
CD4+,T-cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	1.029e-04	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Nos)_source	APP_ligand	CD8+,T-cells(Nos)_target	CD74_receptor	4.330e-05	0.0	APP	Cell-Cell Contact	PMID: 19849849
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.327e-02	0.0	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CLEC2D_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	2.097e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	CLEC2D_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	2.462e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	CLEC2D_ligand	CD8+,T-cells(Nos)_target	KLRB1_receptor	8.248e-04	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	CLEC2B_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	2.460e-03	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	CLEC2B_ligand	CD8+,T-cells(Nos)_target	KLRB1_receptor	8.241e-04	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD4+,T-cells(Nos)_source	CD69_ligand	CD4+,T-cells(Nos)_target	KLRB1_receptor	1.849e-02	0.0	CLEC	Cell-Cell Contact	PMID: 24223577
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD4+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.120e-03	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.366e-03	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	9.611e-04	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	ICAM2_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.944e-03	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM2_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	8.440e-04	0.0	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD4+,T-cells(Nos)_target	ITGAL_receptor	5.256e-04	0.0	ICAM	Cell-Cell Contact	PMID: 23602662
CD4+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_receptor	8.835e-04	0.0	ICAM	Cell-Cell Contact	PMID: 23602662
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_receptor	6.223e-04	0.0	ICAM	Cell-Cell Contact	PMID: 23602662
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD4+,T-cells(Nos)_target	SPN_receptor	3.353e-04	0.0	ICAM	Cell-Cell Contact	PMID: 1683685
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	SPN_receptor	1.905e-04	0.0	ICAM	Cell-Cell Contact	PMID: 1683685
CD4+,T-cells(Nos)_source	ITGB2_ligand	CD8+,T-cells(Nos)_target	ICAM1_receptor	2.381e-03	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGB2_ligand	CD8+,T-cells(Nos)_target	ICAM1_receptor	1.482e-03	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGB2_ligand	CD4+,T-cells(Nos)_target	ICAM2_receptor	2.998e-03	0.0	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPA1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	3.659e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPA1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	2.884e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	2.890e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	2.282e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQA1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	4.909e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQA1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	3.898e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DMA_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	9.733e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DMA_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	7.720e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	6.219e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	4.937e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRA_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.179e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRA_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	9.349e-04	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	2.799e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	HLA-DRB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	1.737e-03	0.02	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	2.210e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB5_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.513e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB5_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	1.199e-03	0.0	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	5.007e-03	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607
CD8+,T-cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	2.690e-03	0.0	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607