Sample overview

Project Name	TCGA-DLBC
GSE ID	GSE242756
GSM ID	GSM7770080
Cell Line	None
Tissue type	lymph nodes
Disease Type	None
PMID	37695745
Initial gene number	33549
Initial cell number	7205
Post-QC gene number	7385
Post-QC cell number	5568

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	Pathway Name	Function	Evidence
CD4+,T-cells(Nos)_source	TGFB1_ligand	CD4+,T-cells(Nos)_target	TGFbR1_R2_receptor	1.719e-05	TGFb	Secreted Signaling	KEGG: hsa04350
CD8+,T-cells(Nos)_source	TGFB1_ligand	CD4+,T-cells(Nos)_target	TGFbR1_R2_receptor	1.438e-05	TGFb	Secreted Signaling	KEGG: hsa04350
CD4+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	1.372e-02	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CXCR4_receptor	1.246e-02	MIF	Secreted Signaling	PMID: 29637711; PMID: 24760155
CD4+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	1.171e-02	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD8+,T-cells(Nos)_source	MIF_ligand	CD8+,T-cells(Nos)_target	CD74_CD44_receptor	1.064e-02	MIF	Secreted Signaling	PMID: 29637711; PMID: 26175090
CD4+,T-cells(Nos)_source	IL21_ligand	CD8+,T-cells(Nos)_target	IL21R_IL2RG_receptor	1.501e-04	IL2	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	IL21_ligand	CD8+,T-cells(Nos)_target	IL21R_IL2RG_receptor	1.459e-04	IL2	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	IL16_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	5.529e-03	IL16	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	IL16_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	4.736e-03	IL16	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	9.462e-05	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1A_receptor	8.529e-05	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	1.761e-03	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF1B_receptor	1.586e-03	LT	Secreted Signaling	KEGG: hsa04060
CD4+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.950e-03	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	LTA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.757e-03	LT	Secreted Signaling	KEGG: hsa04060
CD8+,T-cells(Nos)_source	GZMA_ligand	CD4+,T-cells(Nos)_target	F2R_receptor	2.980e-07	PARs	Secreted Signaling	KEGG: hsa04080
CD8+,T-cells(Nos)_source	GZMA_ligand	CD8+,T-cells(Nos)_target	F2R_receptor	4.188e-04	PARs	Secreted Signaling	KEGG: hsa04080
CD4+,T-cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.140e-03	BTLA	Secreted Signaling	PMID: 21941365
CD8+,T-cells(Nos)_source	BTLA_ligand	CD8+,T-cells(Nos)_target	TNFRSF14_receptor	1.083e-03	BTLA	Secreted Signaling	PMID: 21941365
CD4+,T-cells(Nos)_source	ADGRE5_ligand	CD4+,T-cells(Nos)_target	CD55_receptor	5.048e-04	ADGRE5	Cell-Cell Contact	PMID: 11297558
CD8+,T-cells(Nos)_source	ADGRE5_ligand	CD4+,T-cells(Nos)_target	CD55_receptor	9.728e-04	ADGRE5	Cell-Cell Contact	PMID: 11297558
CD8+,T-cells(Nos)_source	CADM1_ligand	CD8+,T-cells(Nos)_target	CADM1_receptor	2.723e-04	CADM	Cell-Cell Contact	PMID: 24503895
CD8+,T-cells(Nos)_source	CD99_ligand	CD4+,T-cells(Nos)_target	CD99_receptor	1.380e-02	CD99	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.380e-02	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	CD99_ligand	CD8+,T-cells(Nos)_target	CD99_receptor	1.676e-02	CD99	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD4+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	9.304e-04	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	9.013e-04	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.008e-03	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD4+,T-cells(Nos)_source	ICAM2_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.406e-03	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM2_ligand	CD8+,T-cells(Nos)_target	ITGAL_ITGB2_receptor	1.025e-03	ICAM	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD4+,T-cells(Nos)_target	ITGAL_receptor	4.496e-04	ICAM	Cell-Cell Contact	PMID: 23602662
CD4+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_receptor	4.785e-04	ICAM	Cell-Cell Contact	PMID: 23602662
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	ITGAL_receptor	5.355e-04	ICAM	Cell-Cell Contact	PMID: 23602662
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD4+,T-cells(Nos)_target	SPN_receptor	2.745e-04	ICAM	Cell-Cell Contact	PMID: 1683685
CD8+,T-cells(Nos)_source	ICAM1_ligand	CD8+,T-cells(Nos)_target	SPN_receptor	2.727e-04	ICAM	Cell-Cell Contact	PMID: 1683685
CD4+,T-cells(Nos)_source	ITGB2_ligand	CD8+,T-cells(Nos)_target	ICAM1_receptor	1.921e-03	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGB2_ligand	CD8+,T-cells(Nos)_target	ICAM1_receptor	1.894e-03	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	ITGB2_ligand	CD4+,T-cells(Nos)_target	ICAM2_receptor	2.640e-03	ITGB2	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPA1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	4.098e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPA1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	4.928e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	3.435e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DPB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	4.136e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQA1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	5.610e-04	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQA1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	6.789e-04	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DMA_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.042e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DMA_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	1.260e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	5.426e-04	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DQB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	6.567e-04	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRA_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.206e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRA_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	1.458e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB1_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	3.088e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB1_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	3.720e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB5_ligand	CD4+,T-cells(Nos)_target	CD4_receptor	1.217e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	HLA-DRB5_ligand	CD8+,T-cells(Nos)_target	CD4_receptor	1.471e-03	MHC-II	Cell-Cell Contact	KEGG: hsa04514
CD8+,T-cells(Nos)_source	SELPLG_ligand	CD4+,T-cells(Nos)_target	SELL_receptor	6.064e-03	SELPLG	Cell-Cell Contact	PMC2431087; PMID: 8892633,PMID: 8896607