Sample overview
| Project Name | TCGA-COAD |
| GSE ID | GSE217774 |
| GSM ID | GSM6726592 |
| Cell Line | None |
| Tissue type | None |
| Disease Type | Colorectal cancer |
| PMID | \ |
| Initial gene number | 33538 |
| Initial cell number | 6040 |
| Post-QC gene number | 10230 |
| Post-QC cell number | 624 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Epithelial,cells(Nos)_source | GDF15_ligand | Epithelial,cells(Nos)_target | TGFBR2_receptor | 8.442e-04 | 0.0 | GDF | Secreted Signaling | KEGG: hsa04350 |
| Epithelial,cells(Nos)_source | AREG_ligand | Epithelial,cells(Nos)_target | EGFR_receptor | 3.067e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | AREG_ligand | Epithelial,cells(Nos)_target | EGFR_receptor | 2.985e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Epithelial,cells(Nos)_source | AREG_ligand | Epithelial,cells(Nos)_target | EGFR_ERBB2_receptor | 3.110e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | AREG_ligand | Epithelial,cells(Nos)_target | EGFR_ERBB2_receptor | 3.026e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | HBEGF_ligand | Epithelial,cells(Nos)_target | EGFR_receptor | 1.994e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | HBEGF_ligand | Monocytes(Nos)_target | EGFR_receptor | 2.889e-05 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | HBEGF_ligand | Epithelial,cells(Nos)_target | EGFR_ERBB2_receptor | 2.021e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | HBEGF_ligand | Monocytes(Nos)_target | EGFR_ERBB2_receptor | 2.840e-05 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Epithelial,cells(Nos)_target | EGFR_receptor | 4.191e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Monocytes(Nos)_source | EREG_ligand | Epithelial,cells(Nos)_target | EGFR_ERBB2_receptor | 4.249e-04 | 0.0 | EGF | Secreted Signaling | KEGG: hsa04012 |
| Epithelial,cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CXCR4_receptor | 8.394e-04 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 24760155 |
| Epithelial,cells(Nos)_source | MIF_ligand | Monocytes(Nos)_target | CD74_CD44_receptor | 2.002e-03 | 0.0 | MIF | Secreted Signaling | PMID: 29637711; PMID: 26175090 |
| Monocytes(Nos)_source | IL1B_ligand | Monocytes(Nos)_target | IL1R2_receptor | 1.872e-02 | 0.0 | IL1 | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Nos)_source | TNF_ligand | Epithelial,cells(Nos)_target | TNFRSF1A_receptor | 1.348e-04 | 0.0 | TNF | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Nos)_source | TNF_ligand | Monocytes(Nos)_target | TNFRSF1A_receptor | 4.491e-04 | 0.0 | TNF | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Nos)_source | TNF_ligand | Epithelial,cells(Nos)_target | TNFRSF1B_receptor | 1.180e-05 | 0.0 | TNF | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Nos)_source | TNF_ligand | Monocytes(Nos)_target | TNFRSF1B_receptor | 2.048e-03 | 0.0 | TNF | Secreted Signaling | KEGG: hsa04060 |
| Monocytes(Nos)_source | NAMPT_ligand | Epithelial,cells(Nos)_target | INSR_receptor | 6.570e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Monocytes(Nos)_source | NAMPT_ligand | Monocytes(Nos)_target | INSR_receptor | 1.106e-04 | 0.0 | VISFATIN | Secreted Signaling | PMID: 28490838 |
| Epithelial,cells(Nos)_source | MDK_ligand | Epithelial,cells(Nos)_target | SDC1_receptor | 3.135e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | MDK_ligand | Epithelial,cells(Nos)_target | SDC4_receptor | 8.720e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | MDK_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 1.051e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | MDK_ligand | Monocytes(Nos)_target | ITGA6_ITGB1_receptor | 5.311e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | MDK_ligand | Monocytes(Nos)_target | LRP1_receptor | 5.870e-04 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | MDK_ligand | Epithelial,cells(Nos)_target | NCL_receptor | 3.491e-03 | 0.0 | MK | Secreted Signaling | PMID: 28356350 |
| Epithelial,cells(Nos)_source | PRSS3_ligand | Epithelial,cells(Nos)_target | PARD3_receptor | 1.770e-05 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Monocytes(Nos)_source | ANXA1_ligand | Monocytes(Nos)_target | FPR1_receptor | 6.253e-03 | 0.0 | ANNEXIN | Secreted Signaling | PMID: 23230437 |
| Monocytes(Nos)_source | GRN_ligand | Monocytes(Nos)_target | SORT1_receptor | 7.436e-05 | 0.0 | GRN | Secreted Signaling | PMID: 29555433 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Epithelial,cells(Nos)_target | ITGA1_ITGB1_receptor | 4.704e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Monocytes(Nos)_target | ITGA1_ITGB1_receptor | 5.389e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 5.437e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Monocytes(Nos)_target | ITGA2_ITGB1_receptor | 5.401e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB1_receptor | 8.184e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Monocytes(Nos)_target | ITGA6_ITGB1_receptor | 4.128e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Epithelial,cells(Nos)_target | ITGA6_ITGB4_receptor | 6.329e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Monocytes(Nos)_target | ITGA6_ITGB4_receptor | 1.004e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Epithelial,cells(Nos)_target | CD44_receptor | 2.674e-05 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | LAMB3_ligand | Monocytes(Nos)_target | CD44_receptor | 4.492e-04 | 0.0 | LAMININ | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | THBS1_ligand | Epithelial,cells(Nos)_target | SDC1_receptor | 2.701e-05 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Epithelial,cells(Nos)_target | SDC1_receptor | 6.293e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Epithelial,cells(Nos)_target | SDC4_receptor | 1.746e-03 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | THBS1_ligand | Epithelial,cells(Nos)_target | CD47_receptor | 8.173e-04 | 0.0 | THBS | ECM-Receptor | KEGG: hsa04512 |
| Monocytes(Nos)_source | ADGRE5_ligand | Monocytes(Nos)_target | CD55_receptor | 1.820e-03 | 0.0 | ADGRE5 | Cell-Cell Contact | PMID: 11297558 |
| Epithelial,cells(Nos)_source | APP_ligand | Monocytes(Nos)_target | CD74_receptor | 1.949e-03 | 0.0 | APP | Cell-Cell Contact | PMID: 19849849 |
| Monocytes(Nos)_source | CD99_ligand | Epithelial,cells(Nos)_target | CD99_receptor | 2.741e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 2.741e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | CD99_ligand | Monocytes(Nos)_target | CD99_receptor | 9.209e-04 | 0.0 | CD99 | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CDH1_ligand | Epithelial,cells(Nos)_target | CDH1_receptor | 3.778e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CDH1_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 3.095e-04 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| Epithelial,cells(Nos)_source | CDH1_ligand | Monocytes(Nos)_target | ITGA2_ITGB1_receptor | 3.074e-04 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| Epithelial,cells(Nos)_source | CEACAM1_ligand | Epithelial,cells(Nos)_target | CEACAM5_receptor | 1.297e-03 | 0.0 | CEACAM | Cell-Cell Contact | PMID: 11590190 |
| Epithelial,cells(Nos)_source | CEACAM1_ligand | Monocytes(Nos)_target | CEACAM5_receptor | 6.843e-05 | 0.0 | CEACAM | Cell-Cell Contact | PMID: 11590190 |
| Epithelial,cells(Nos)_source | EFNA1_ligand | Epithelial,cells(Nos)_target | EPHA1_receptor | 1.358e-04 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNA1_ligand | Epithelial,cells(Nos)_target | EPHA2_receptor | 6.917e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNA4_ligand | Epithelial,cells(Nos)_target | EPHA1_receptor | 3.445e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNA4_ligand | Epithelial,cells(Nos)_target | EPHA2_receptor | 1.755e-05 | 0.0 | EPHA | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB1_ligand | Epithelial,cells(Nos)_target | EPHB2_receptor | 7.897e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB1_ligand | Monocytes(Nos)_target | EPHB2_receptor | 9.152e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB1_ligand | Epithelial,cells(Nos)_target | EPHB4_receptor | 3.603e-05 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB1_ligand | Monocytes(Nos)_target | EPHB4_receptor | 8.091e-08 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB2_ligand | Epithelial,cells(Nos)_target | EPHB2_receptor | 5.610e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB2_ligand | Monocytes(Nos)_target | EPHB2_receptor | 6.503e-06 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Epithelial,cells(Nos)_source | EFNB2_ligand | Epithelial,cells(Nos)_target | EPHB4_receptor | 2.560e-05 | 0.0 | EPHB | Cell-Cell Contact | PMID: 15114347 |
| Monocytes(Nos)_source | ICAM1_ligand | Monocytes(Nos)_target | ITGAX_ITGB2_receptor | 6.724e-03 | 0.0 | ICAM | Cell-Cell Contact | PMID: 16252253 |
| Monocytes(Nos)_source | ITGB2_ligand | Monocytes(Nos)_target | ICAM1_receptor | 7.362e-03 | 0.0 | ITGB2 | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | F11R_ligand | Epithelial,cells(Nos)_target | F11R_receptor | 2.334e-04 | 0.0 | JAM | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPA1_ligand | Monocytes(Nos)_target | CD4_receptor | 4.643e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DPB1_ligand | Monocytes(Nos)_target | CD4_receptor | 3.573e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQA1_ligand | Monocytes(Nos)_target | CD4_receptor | 2.336e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMA_ligand | Monocytes(Nos)_target | CD4_receptor | 1.124e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMB_ligand | Epithelial,cells(Nos)_target | CD4_receptor | 1.570e-05 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DMB_ligand | Monocytes(Nos)_target | CD4_receptor | 1.024e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DQB1_ligand | Monocytes(Nos)_target | CD4_receptor | 2.271e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRA_ligand | Monocytes(Nos)_target | CD4_receptor | 9.227e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | HLA-DRB1_ligand | Monocytes(Nos)_target | CD4_receptor | 2.947e-03 | 0.0 | MHC-II | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | MPZL1_ligand | Epithelial,cells(Nos)_target | MPZL1_receptor | 6.185e-05 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | MPZL1_ligand | Epithelial,cells(Nos)_target | MPZL1_receptor | 2.437e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | MPZL1_ligand | Monocytes(Nos)_target | MPZL1_receptor | 2.437e-06 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | JAG1_ligand | Epithelial,cells(Nos)_target | NOTCH1_receptor | 1.178e-06 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Epithelial,cells(Nos)_source | JAG1_ligand | Monocytes(Nos)_target | NOTCH1_receptor | 2.940e-07 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Epithelial,cells(Nos)_source | JAG1_ligand | Monocytes(Nos)_target | NOTCH2_receptor | 6.886e-05 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Monocytes(Nos)_source | JAG1_ligand | Monocytes(Nos)_target | NOTCH2_receptor | 1.284e-06 | 0.0 | NOTCH | Cell-Cell Contact | PMID: 22353464 |
| Epithelial,cells(Nos)_source | OCLN_ligand | Epithelial,cells(Nos)_target | OCLN_receptor | 2.829e-05 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Monocytes(Nos)_source | OCLN_ligand | Epithelial,cells(Nos)_target | OCLN_receptor | 3.527e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | OCLN_ligand | Monocytes(Nos)_target | OCLN_receptor | 3.527e-07 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | SEMA4D_ligand | Epithelial,cells(Nos)_target | PLXNB1_receptor | 5.399e-06 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Epithelial,cells(Nos)_source | SEMA4D_ligand | Epithelial,cells(Nos)_target | PLXNB2_receptor | 1.100e-08 | 0.0 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |
| Epithelial,cells(Nos)_source | SEMA4D_ligand | Monocytes(Nos)_target | PLXNB2_receptor | 4.329e-09 | 0.01 | SEMA4 | Cell-Cell Contact | PMID: 27533782 |