Sample overview
| Project Name | TCGA-COAD |
| GSE ID | GSE201348 |
| GSM ID | GSM6061708 |
| Cell Line | None |
| Tissue type | Colon |
| Disease Type | Polyp |
| PMID | 35726067 |
| Initial gene number | 33538 |
| Initial cell number | 75717 |
| Post-QC gene number | 2074 |
| Post-QC cell number | 1248 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| CD4+,T-cells(Nos)_source | FN1_ligand | CD4+,T-cells(Good)_target | ITGAV_ITGB1_receptor | 8.452e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Good)_source | FN1_ligand | CD4+,T-cells(Nos)_target | ITGAV_ITGB1_receptor | 3.209e-11 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | CD4+,T-cells(Nos)_target | ITGAV_ITGB1_receptor | 1.307e-09 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Good)_source | FN1_ligand | CD4+,T-cells(Nos)_target | ITGAV_ITGB1_receptor | 6.501e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | FN1_ligand | CD4+,T-cells(Nos)_target | ITGAV_ITGB1_receptor | 1.253e-10 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Neutrophils(Good)_source | FN1_ligand | CD4+,T-cells(Nos)_target | ITGAV_ITGB1_receptor | 1.747e-11 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Neutrophils(Nos)_source | FN1_ligand | CD4+,T-cells(Nos)_target | ITGAV_ITGB1_receptor | 7.658e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Epithelial,cells(Good)_target | ITGAV_ITGB1_receptor | 9.326e-13 | 0.01 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Epithelial,cells(Nos)_target | ITGAV_ITGB1_receptor | 1.999e-11 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Neutrophils(Good)_target | ITGAV_ITGB1_receptor | 2.703e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Neutrophils(Nos)_target | ITGAV_ITGB1_receptor | 1.325e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Good)_source | FN1_ligand | CD4+,T-cells(Good)_target | CD44_receptor | 2.117e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | CD4+,T-cells(Good)_target | CD44_receptor | 8.620e-11 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Good)_source | FN1_ligand | CD4+,T-cells(Good)_target | CD44_receptor | 4.289e-13 | 0.04 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | FN1_ligand | CD4+,T-cells(Good)_target | CD44_receptor | 8.266e-12 | 0.01 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Neutrophils(Good)_source | FN1_ligand | CD4+,T-cells(Good)_target | CD44_receptor | 1.152e-12 | 0.03 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Neutrophils(Nos)_source | FN1_ligand | CD4+,T-cells(Good)_target | CD44_receptor | 5.051e-13 | 0.02 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Good)_source | FN1_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 1.668e-11 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 6.794e-10 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Good)_source | FN1_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 3.380e-12 | 0.01 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Epithelial,cells(Nos)_source | FN1_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 6.514e-11 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Neutrophils(Good)_source | FN1_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 9.079e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| Neutrophils(Nos)_source | FN1_ligand | CD4+,T-cells(Nos)_target | CD44_receptor | 3.981e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Epithelial,cells(Good)_target | CD44_receptor | 5.125e-12 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Epithelial,cells(Nos)_target | CD44_receptor | 3.824e-11 | 0.0 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Neutrophils(Good)_target | CD44_receptor | 2.472e-12 | 0.01 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Nos)_source | FN1_ligand | Neutrophils(Nos)_target | CD44_receptor | 1.835e-12 | 0.01 | FN1 | ECM-Receptor | KEGG: hsa04512 |
| CD4+,T-cells(Good)_source | CD46_ligand | CD4+,T-cells(Good)_target | JAG1_receptor | 1.726e-13 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| CD4+,T-cells(Nos)_source | CD46_ligand | CD4+,T-cells(Good)_target | JAG1_receptor | 3.058e-12 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| Epithelial,cells(Good)_source | CD46_ligand | CD4+,T-cells(Good)_target | JAG1_receptor | 1.637e-13 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| CD4+,T-cells(Good)_source | CD46_ligand | CD4+,T-cells(Nos)_target | JAG1_receptor | 3.195e-12 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| CD4+,T-cells(Nos)_source | CD46_ligand | CD4+,T-cells(Nos)_target | JAG1_receptor | 5.661e-11 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| Epithelial,cells(Good)_source | CD46_ligand | CD4+,T-cells(Nos)_target | JAG1_receptor | 3.031e-12 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| CD4+,T-cells(Good)_source | CD46_ligand | Epithelial,cells(Good)_target | JAG1_receptor | 1.430e-13 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| CD4+,T-cells(Nos)_source | CD46_ligand | Epithelial,cells(Good)_target | JAG1_receptor | 2.534e-12 | 0.0 | CD46 | Cell-Cell Contact | PMID: 23086448 |
| CD4+,T-cells(Good)_source | CDH1_ligand | CD4+,T-cells(Good)_target | CDH1_receptor | 8.480e-12 | 0.03 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | CD4+,T-cells(Good)_target | CDH1_receptor | 1.942e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | CDH1_receptor | 1.942e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | CDH1_receptor | 4.448e-09 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Good)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | CDH1_receptor | 1.455e-11 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | CDH1_receptor | 1.478e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neutrophils(Good)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | CDH1_receptor | 1.614e-11 | 0.03 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | Epithelial,cells(Good)_target | CDH1_receptor | 1.455e-11 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | Epithelial,cells(Nos)_target | CDH1_receptor | 1.478e-10 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | Neutrophils(Good)_target | CDH1_receptor | 1.614e-11 | 0.03 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | CD4+,T-cells(Good)_target | ITGA2_ITGB1_receptor | 2.662e-11 | 0.03 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| CD4+,T-cells(Good)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | ITGA2_ITGB1_receptor | 1.139e-09 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | ITGA2_ITGB1_receptor | 2.609e-08 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| Epithelial,cells(Good)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | ITGA2_ITGB1_receptor | 8.534e-11 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| Epithelial,cells(Nos)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | ITGA2_ITGB1_receptor | 8.667e-10 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| Neutrophils(Good)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | ITGA2_ITGB1_receptor | 9.465e-11 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| Neutrophils(Nos)_source | CDH1_ligand | CD4+,T-cells(Nos)_target | ITGA2_ITGB1_receptor | 3.715e-11 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | Epithelial,cells(Good)_target | ITGA2_ITGB1_receptor | 4.845e-12 | 0.01 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | Epithelial,cells(Nos)_target | ITGA2_ITGB1_receptor | 9.745e-11 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | Neutrophils(Good)_target | ITGA2_ITGB1_receptor | 1.231e-11 | 0.0 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| CD4+,T-cells(Nos)_source | CDH1_ligand | Neutrophils(Nos)_target | ITGA2_ITGB1_receptor | 2.829e-12 | 0.03 | CDH1 | Cell-Cell Contact | PMID: 12392763 |
| CD4+,T-cells(Good)_source | MPZL1_ligand | CD4+,T-cells(Good)_target | MPZL1_receptor | 1.738e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | CD4+,T-cells(Good)_target | MPZL1_receptor | 7.867e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Good)_source | MPZL1_ligand | CD4+,T-cells(Good)_target | MPZL1_receptor | 9.764e-12 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | MPZL1_ligand | CD4+,T-cells(Good)_target | MPZL1_receptor | 5.590e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Neutrophils(Good)_source | MPZL1_ligand | CD4+,T-cells(Good)_target | MPZL1_receptor | 4.483e-12 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Neutrophils(Nos)_source | MPZL1_ligand | CD4+,T-cells(Good)_target | MPZL1_receptor | 3.270e-12 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 7.867e-09 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 3.561e-08 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Good)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 4.420e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 2.531e-10 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Neutrophils(Good)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 2.029e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| Neutrophils(Nos)_source | MPZL1_ligand | CD4+,T-cells(Nos)_target | MPZL1_receptor | 1.480e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | MPZL1_ligand | Epithelial,cells(Good)_target | MPZL1_receptor | 9.764e-12 | 0.01 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | Epithelial,cells(Good)_target | MPZL1_receptor | 4.420e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | MPZL1_ligand | Epithelial,cells(Nos)_target | MPZL1_receptor | 5.590e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | Epithelial,cells(Nos)_target | MPZL1_receptor | 2.531e-10 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | MPZL1_ligand | Neutrophils(Good)_target | MPZL1_receptor | 4.483e-12 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | Neutrophils(Good)_target | MPZL1_receptor | 2.029e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | MPZL1_ligand | Neutrophils(Nos)_target | MPZL1_receptor | 3.270e-12 | 0.02 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | MPZL1_ligand | Neutrophils(Nos)_target | MPZL1_receptor | 1.480e-11 | 0.0 | MPZ | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | OCLN_ligand | CD4+,T-cells(Good)_target | OCLN_receptor | 1.254e-13 | 0.01 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | OCLN_ligand | CD4+,T-cells(Good)_target | OCLN_receptor | 2.375e-11 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Good)_source | OCLN_ligand | CD4+,T-cells(Good)_target | OCLN_receptor | 1.153e-13 | 0.01 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | OCLN_ligand | CD4+,T-cells(Nos)_target | OCLN_receptor | 2.375e-11 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | OCLN_ligand | CD4+,T-cells(Nos)_target | OCLN_receptor | 4.496e-09 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Good)_source | OCLN_ligand | CD4+,T-cells(Nos)_target | OCLN_receptor | 2.184e-11 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Epithelial,cells(Nos)_source | OCLN_ligand | CD4+,T-cells(Nos)_target | OCLN_receptor | 4.860e-11 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Neutrophils(Good)_source | OCLN_ligand | CD4+,T-cells(Nos)_target | OCLN_receptor | 4.714e-12 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| Neutrophils(Nos)_source | OCLN_ligand | CD4+,T-cells(Nos)_target | OCLN_receptor | 4.148e-12 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Good)_source | OCLN_ligand | Epithelial,cells(Good)_target | OCLN_receptor | 1.153e-13 | 0.01 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | OCLN_ligand | Epithelial,cells(Good)_target | OCLN_receptor | 2.184e-11 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | OCLN_ligand | Epithelial,cells(Nos)_target | OCLN_receptor | 4.860e-11 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | OCLN_ligand | Neutrophils(Good)_target | OCLN_receptor | 4.714e-12 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |
| CD4+,T-cells(Nos)_source | OCLN_ligand | Neutrophils(Nos)_target | OCLN_receptor | 4.148e-12 | 0.0 | OCLN | Cell-Cell Contact | KEGG: hsa04514 |