Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061702
Cell Line	None
Tissue type	Colon
Disease Type	CRC
PMID	35726067
Initial gene number	33538
Initial cell number	9109
Post-QC gene number	7334
Post-QC cell number	9028

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Nos)_source	FGF9_ligand	Epithelial,cells(Nos)_target	FGFR3_receptor	3.050e-09	0.0	FGF	Secreted Signaling	PMC: 4393358
Epithelial,cells(Nos)_source	FGF9_ligand	Epithelial,cells(Nos)_target	FGFR4_receptor	2.051e-09	0.0	FGF	Secreted Signaling	PMC: 4393358
Epithelial,cells(Nos)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	3.223e-02	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	SEMA3C_ligand	Epithelial,cells(Nos)_target	NRP1_PLXNA2_receptor	1.814e-03	0.0	SEMA3	Secreted Signaling	PMID: 27533782
Epithelial,cells(Nos)_source	LAMA2_ligand	Chondrocytes(Nos)_target	ITGA1_ITGB1_receptor	1.554e-04	0.02	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA2_ligand	Epithelial,cells(Nos)_target	ITGA1_ITGB1_receptor	4.179e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Chondrocytes(Nos)_target	ITGA1_ITGB1_receptor	1.063e-05	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Nos)_target	ITGA1_ITGB1_receptor	2.857e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Monocytes(Nos)_target	ITGA1_ITGB1_receptor	8.655e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA2_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.637e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Chondrocytes(Nos)_target	ITGA2_ITGB1_receptor	8.150e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	3.169e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Monocytes(Nos)_target	ITGA2_ITGB1_receptor	8.119e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	8.747e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Chondrocytes(Nos)_target	ITGA6_ITGB1_receptor	6.819e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB1_receptor	5.969e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Monocytes(Nos)_target	ITGA6_ITGB1_receptor	6.798e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA2_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	8.767e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Chondrocytes(Nos)_target	ITGA6_ITGB4_receptor	6.911e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Nos)_target	ITGA6_ITGB4_receptor	5.982e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Monocytes(Nos)_target	ITGA6_ITGB4_receptor	7.640e-06	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	LAMA2_ligand	Epithelial,cells(Nos)_target	CD44_receptor	5.728e-03	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Chondrocytes(Nos)_target	CD44_receptor	3.155e-07	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Epithelial,cells(Nos)_target	CD44_receptor	3.913e-04	0.0	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	LAMB1_ligand	Monocytes(Nos)_target	CD44_receptor	2.592e-07	0.01	LAMININ	ECM-Receptor	KEGG: hsa04512
Chondrocytes(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	CD47_receptor	1.470e-05	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	THBS1_ligand	Epithelial,cells(Nos)_target	CD47_receptor	6.091e-05	0.0	THBS	ECM-Receptor	KEGG: hsa04512
Epithelial,cells(Nos)_source	CD46_ligand	Chondrocytes(Nos)_target	JAG1_receptor	9.655e-04	0.01	CD46	Cell-Cell Contact	PMID: 23086448
Epithelial,cells(Nos)_source	CD46_ligand	Epithelial,cells(Nos)_target	JAG1_receptor	8.012e-03	0.0	CD46	Cell-Cell Contact	PMID: 23086448
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	6.506e-03	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	ITGA2_ITGB1_receptor	4.708e-03	0.0	CDH1	Cell-Cell Contact	PMID: 12392763
Epithelial,cells(Nos)_source	EFNA1_ligand	Epithelial,cells(Nos)_target	EPHA2_receptor	6.256e-07	0.0	EPHA	Cell-Cell Contact	PMID: 15114347
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	2.822e-05	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	JAG1_ligand	Epithelial,cells(Nos)_target	NOTCH1_receptor	2.065e-04	0.02	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	JAG1_ligand	Epithelial,cells(Nos)_target	NOTCH1_receptor	1.696e-03	0.0	NOTCH	Cell-Cell Contact	PMID: 22353464
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	2.658e-06	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514