Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061700
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	7060
Post-QC gene number	2511
Post-QC cell number	7040

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Epithelial,cells(Good)_source	PRSS3_ligand	Epithelial,cells(Good)_target	PARD3_receptor	2.230e-07	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Epithelial,cells(Good)_target	PARD3_receptor	1.560e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	4.783e-06	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Epithelial,cells(Nos)_target	PARD3_receptor	3.365e-04	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	7.764e-07	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	5.460e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.552e-05	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.091e-03	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Epithelial,cells(Good)_source	LGALS9_ligand	Chondrocytes(Good)_target	CD44_receptor	4.143e-11	0.02	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Good)_source	LGALS9_ligand	Chondrocytes(Nos)_target	CD44_receptor	3.123e-09	0.02	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Good)_source	LGALS9_ligand	Epithelial,cells(Good)_target	CD44_receptor	1.902e-10	0.02	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Good)_source	LGALS9_ligand	Epithelial,cells(Nos)_target	CD44_receptor	1.954e-08	0.01	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Good)_source	LGALS9_ligand	Neurons(Good)_target	CD44_receptor	1.873e-09	0.01	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Good)_source	LGALS9_ligand	Neurons(Nos)_target	CD44_receptor	3.660e-08	0.01	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Good)_source	LGALS9_ligand	Skeletal,muscle(Good)_target	CD44_receptor	4.982e-10	0.02	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Good)_source	LGALS9_ligand	Skeletal,muscle(Nos)_target	CD44_receptor	4.801e-08	0.01	GALECTIN	Secreted Signaling	PMID: 25065622
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Good)_target	CDH1_receptor	1.893e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.893e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.530e-04	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	1.652e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	4.460e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Good)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	8.470e-08	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	CDH1_ligand	Epithelial,cells(Nos)_target	CDH1_receptor	4.048e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.652e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	4.460e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Skeletal,muscle(Good)_target	CDH1_receptor	8.470e-08	0.04	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	CDH1_ligand	Skeletal,muscle(Nos)_target	CDH1_receptor	4.048e-06	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	DSC2_ligand	Epithelial,cells(Good)_target	DSG2_receptor	3.479e-06	0.0	DESMOSOME	Cell-Cell Contact	PMID: 27298358
Epithelial,cells(Nos)_source	MPZL1_ligand	Chondrocytes(Nos)_target	MPZL1_receptor	9.528e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	MPZL1_ligand	Chondrocytes(Nos)_target	MPZL1_receptor	2.026e-07	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Good)_target	MPZL1_receptor	7.612e-09	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	MPZL1_ligand	Epithelial,cells(Good)_target	MPZL1_receptor	1.618e-08	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	9.528e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	7.612e-09	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	6.162e-07	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	7.336e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	1.310e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	MPZL1_ligand	Epithelial,cells(Nos)_target	MPZL1_receptor	6.636e-07	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Neurons(Good)_target	MPZL1_receptor	7.336e-08	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	MPZL1_ligand	Neurons(Good)_target	MPZL1_receptor	8.732e-09	0.02	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	MPZL1_ligand	Neurons(Good)_target	MPZL1_receptor	1.560e-07	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Chondrocytes(Nos)_source	MPZL1_ligand	Neurons(Nos)_target	MPZL1_receptor	2.026e-07	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	MPZL1_ligand	Neurons(Nos)_target	MPZL1_receptor	1.618e-08	0.04	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Neurons(Nos)_target	MPZL1_receptor	1.310e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	MPZL1_ligand	Neurons(Nos)_target	MPZL1_receptor	1.560e-07	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	MPZL1_ligand	Neurons(Nos)_target	MPZL1_receptor	2.786e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	MPZL1_ligand	Neurons(Nos)_target	MPZL1_receptor	1.411e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	MPZL1_ligand	Skeletal,muscle(Nos)_target	MPZL1_receptor	6.636e-07	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	MPZL1_ligand	Skeletal,muscle(Nos)_target	MPZL1_receptor	1.411e-06	0.0	MPZ	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	OCLN_ligand	Epithelial,cells(Good)_target	OCLN_receptor	1.437e-11	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Good)_target	OCLN_receptor	3.872e-10	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	OCLN_ligand	Epithelial,cells(Good)_target	OCLN_receptor	5.265e-11	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	OCLN_ligand	Epithelial,cells(Good)_target	OCLN_receptor	1.021e-09	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Skeletal,muscle(Nos)_source	OCLN_ligand	Epithelial,cells(Good)_target	OCLN_receptor	9.191e-10	0.04	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	3.872e-10	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	1.044e-08	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	1.419e-09	0.03	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	OCLN_ligand	Epithelial,cells(Nos)_target	OCLN_receptor	2.751e-08	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	OCLN_ligand	Neurons(Good)_target	OCLN_receptor	5.265e-11	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	OCLN_ligand	Neurons(Good)_target	OCLN_receptor	1.419e-09	0.03	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	OCLN_ligand	Neurons(Nos)_target	OCLN_receptor	1.021e-09	0.02	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	OCLN_ligand	Neurons(Nos)_target	OCLN_receptor	2.751e-08	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	OCLN_ligand	Neurons(Nos)_target	OCLN_receptor	7.255e-08	0.0	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Good)_source	OCLN_ligand	Skeletal,muscle(Nos)_target	OCLN_receptor	9.191e-10	0.04	OCLN	Cell-Cell Contact	KEGG: hsa04514
Epithelial,cells(Nos)_source	SEMA6A_ligand	Chondrocytes(Good)_target	PLXNA2_receptor	4.783e-10	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Chondrocytes(Nos)_target	PLXNA2_receptor	1.982e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Good)_source	SEMA6A_ligand	Epithelial,cells(Good)_target	PLXNA2_receptor	1.260e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Epithelial,cells(Good)_target	PLXNA2_receptor	3.886e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Good)_source	SEMA6A_ligand	Epithelial,cells(Nos)_target	PLXNA2_receptor	7.151e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Epithelial,cells(Nos)_target	PLXNA2_receptor	2.231e-04	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Neurons(Good)_target	PLXNA2_receptor	6.274e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Neurons(Nos)_target	PLXNA2_receptor	1.155e-06	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Good)_target	PLXNA2_receptor	2.755e-08	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Good)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	4.547e-07	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782
Epithelial,cells(Nos)_source	SEMA6A_ligand	Skeletal,muscle(Nos)_target	PLXNA2_receptor	1.401e-05	0.0	SEMA6	Cell-Cell Contact	PMID: 27533782