Sample overview

Project Name	TCGA-COAD
GSE ID	GSE201348
GSM ID	GSM6061699
Cell Line	None
Tissue type	Colon
Disease Type	Polyp
PMID	35726067
Initial gene number	33538
Initial cell number	14122
Post-QC gene number	921
Post-QC cell number	11406

QC Metrics

Bulk-to-ScRNA-seq Label Transfer

Bulk phenotype-associated subpopulations

Reference-Based Annotation

Differentially expressed genes

Overall Survival : Cluster vs

Overall Survival : Cluster vs ( + )

Clinical Stage : Cluster vs

Tumor Size : Cluster vs

Lymph Node Involvement : Cluster vs

Distant Metastasis : Cluster vs

Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )

Cell Population Signaling and Communication

Ligand-Receptor-Mediated Cell-Cell Interactions

Sending Cell Type	Ligand	Receiving Cell Type	Receptor	Score	P-value	Pathway Name	Function	Evidence
Neurons(Nos)_source	PRSS3_ligand	HSC(Nos)_target	PARD3_receptor	2.867e-11	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	HSC(Nos)_target	PARD3_receptor	2.007e-11	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	1.443e-13	0.02	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	9.748e-12	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neurons(Good)_target	PARD3_receptor	6.826e-12	0.01	PARs	Secreted Signaling	KEGG: hsa04080
HSC(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	3.675e-12	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	9.172e-12	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	6.198e-10	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Good)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	1.948e-12	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neurons(Nos)_target	PARD3_receptor	4.340e-10	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Neutrophils(Good)_target	PARD3_receptor	5.405e-14	0.03	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Neutrophils(Good)_target	PARD3_receptor	3.653e-12	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neutrophils(Good)_target	PARD3_receptor	2.558e-12	0.01	PARs	Secreted Signaling	KEGG: hsa04080
HSC(Good)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	1.989e-12	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Good)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	4.965e-12	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neurons(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	3.355e-10	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Good)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	1.054e-12	0.01	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	PRSS3_ligand	Neutrophils(Nos)_target	PARD3_receptor	2.349e-10	0.0	PARs	Secreted Signaling	KEGG: hsa04080
Neutrophils(Nos)_source	CDH1_ligand	HSC(Good)_target	CDH1_receptor	5.078e-12	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	HSC(Nos)_target	CDH1_receptor	2.602e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.216e-11	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Good)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.354e-13	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neurons(Good)_target	CDH1_receptor	1.532e-11	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	1.216e-11	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	5.551e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Good)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	6.179e-12	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neurons(Nos)_target	CDH1_receptor	6.992e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Neutrophils(Good)_target	CDH1_receptor	1.354e-13	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Neutrophils(Good)_target	CDH1_receptor	6.179e-12	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neutrophils(Good)_target	CDH1_receptor	7.784e-12	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	5.078e-12	0.01	CDH	Cell-Cell Contact	KEGG: hsa04514
HSC(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	2.602e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	1.532e-11	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neurons(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	6.992e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Good)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	7.784e-12	0.02	CDH	Cell-Cell Contact	KEGG: hsa04514
Neutrophils(Nos)_source	CDH1_ligand	Neutrophils(Nos)_target	CDH1_receptor	8.807e-10	0.0	CDH	Cell-Cell Contact	KEGG: hsa04514