Sample overview
| Project Name | TCGA-COAD |
| GSE ID | GSE201348 |
| GSM ID | GSM6061698 |
| Cell Line | None |
| Tissue type | Colon |
| Disease Type | Unaffected |
| PMID | 35726067 |
| Initial gene number | 33538 |
| Initial cell number | 1179 |
| Post-QC gene number | 1169 |
| Post-QC cell number | 1075 |
QC Metrics
Bulk-to-ScRNA-seq Label Transfer
Bulk phenotype-associated subpopulations
Reference-Based Annotation
Differentially expressed genes
Overall Survival : Cluster vs
There are no results of the analysis here
Overall Survival : Cluster vs ( + )
There are no results of the analysis here
Clinical Stage : Cluster vs
There are no results of the analysis here
Tumor Size : Cluster vs
There are no results of the analysis here
Lymph Node Involvement : Cluster vs
There are no results of the analysis here
Distant Metastasis : Cluster vs
There are no results of the analysis here
Cell-Cell communications ( Survival-Associated Subpopulations Across Cell Types )
Cell Population Signaling and Communication
Ligand-Receptor-Mediated Cell-Cell Interactions
| Sending Cell Type | Ligand | Receiving Cell Type | Receptor | Score | P-value | Pathway Name | Function | Evidence |
|---|---|---|---|---|---|---|---|---|
| Adipocytes(Nos)_source | PRSS3_ligand | Adipocytes(Good)_target | PARD3_receptor | 2.180e-04 | 0.03 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Adipocytes(Good)_target | PARD3_receptor | 1.209e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Adipocytes(Good)_target | PARD3_receptor | 1.518e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Adipocytes(Good)_target | PARD3_receptor | 6.412e-05 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Adipocytes(Good)_target | PARD3_receptor | 2.254e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Adipocytes(Nos)_target | PARD3_receptor | 1.167e-03 | 0.01 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Adipocytes(Nos)_target | PARD3_receptor | 1.463e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Adipocytes(Nos)_target | PARD3_receptor | 6.194e-04 | 0.04 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Adipocytes(Nos)_target | PARD3_receptor | 2.169e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | PRSS3_ligand | Chondrocytes(Good)_target | PARD3_receptor | 3.763e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Chondrocytes(Good)_target | PARD3_receptor | 2.092e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Chondrocytes(Good)_target | PARD3_receptor | 2.625e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Chondrocytes(Good)_target | PARD3_receptor | 1.110e-04 | 0.01 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Chondrocytes(Good)_target | PARD3_receptor | 3.896e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | PRSS3_ligand | Mesangial,cells(Good)_target | PARD3_receptor | 1.170e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Mesangial,cells(Good)_target | PARD3_receptor | 6.493e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Mesangial,cells(Good)_target | PARD3_receptor | 8.153e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Mesangial,cells(Good)_target | PARD3_receptor | 3.443e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Mesangial,cells(Good)_target | PARD3_receptor | 1.210e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | PRSS3_ligand | Mesangial,cells(Nos)_target | PARD3_receptor | 1.583e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Mesangial,cells(Nos)_target | PARD3_receptor | 8.772e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Mesangial,cells(Nos)_target | PARD3_receptor | 1.102e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Neurons(Nos)_source | PRSS3_ligand | Mesangial,cells(Nos)_target | PARD3_receptor | 1.463e-03 | 0.03 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Mesangial,cells(Nos)_target | PARD3_receptor | 4.651e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Mesangial,cells(Nos)_target | PARD3_receptor | 1.636e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Good)_source | PRSS3_ligand | Neurons(Nos)_target | PARD3_receptor | 2.681e-04 | 0.04 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | PRSS3_ligand | Neurons(Nos)_target | PARD3_receptor | 3.415e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Neurons(Nos)_target | PARD3_receptor | 1.884e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Neurons(Nos)_target | PARD3_receptor | 2.369e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Neurons(Nos)_source | PRSS3_ligand | Neurons(Nos)_target | PARD3_receptor | 3.167e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Neurons(Nos)_target | PARD3_receptor | 9.983e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Neurons(Nos)_target | PARD3_receptor | 3.519e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | PRSS3_ligand | Skeletal,muscle(Good)_target | PARD3_receptor | 6.291e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Skeletal,muscle(Good)_target | PARD3_receptor | 3.485e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Skeletal,muscle(Good)_target | PARD3_receptor | 4.377e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Skeletal,muscle(Good)_target | PARD3_receptor | 1.848e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Skeletal,muscle(Good)_target | PARD3_receptor | 6.499e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | PRSS3_ligand | Skeletal,muscle(Nos)_target | PARD3_receptor | 2.422e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Good)_source | PRSS3_ligand | Skeletal,muscle(Nos)_target | PARD3_receptor | 1.342e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Mesangial,cells(Nos)_source | PRSS3_ligand | Skeletal,muscle(Nos)_target | PARD3_receptor | 1.686e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Good)_source | PRSS3_ligand | Skeletal,muscle(Nos)_target | PARD3_receptor | 7.117e-04 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Skeletal,muscle(Nos)_source | PRSS3_ligand | Skeletal,muscle(Nos)_target | PARD3_receptor | 2.503e-03 | 0.0 | PARs | Secreted Signaling | KEGG: hsa04080 |
| Adipocytes(Nos)_source | CDH1_ligand | Adipocytes(Nos)_target | CDH1_receptor | 1.435e-03 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Good)_source | CDH1_ligand | Adipocytes(Nos)_target | CDH1_receptor | 9.019e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Nos)_source | CDH1_ligand | Adipocytes(Nos)_target | CDH1_receptor | 1.161e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Adipocytes(Nos)_target | CDH1_receptor | 4.309e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Adipocytes(Nos)_target | CDH1_receptor | 1.528e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CDH1_ligand | Mesangial,cells(Good)_target | CDH1_receptor | 9.019e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Good)_source | CDH1_ligand | Mesangial,cells(Good)_target | CDH1_receptor | 5.601e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Nos)_source | CDH1_ligand | Mesangial,cells(Good)_target | CDH1_receptor | 7.217e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH1_ligand | Mesangial,cells(Good)_target | CDH1_receptor | 8.530e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Mesangial,cells(Good)_target | CDH1_receptor | 2.684e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Mesangial,cells(Good)_target | CDH1_receptor | 9.549e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CDH1_ligand | Mesangial,cells(Nos)_target | CDH1_receptor | 1.161e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Good)_source | CDH1_ligand | Mesangial,cells(Nos)_target | CDH1_receptor | 7.217e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Nos)_source | CDH1_ligand | Mesangial,cells(Nos)_target | CDH1_receptor | 9.299e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH1_ligand | Mesangial,cells(Nos)_target | CDH1_receptor | 1.098e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Mesangial,cells(Nos)_target | CDH1_receptor | 3.458e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Mesangial,cells(Nos)_target | CDH1_receptor | 1.230e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Good)_source | CDH1_ligand | Neurons(Nos)_target | CDH1_receptor | 8.530e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Nos)_source | CDH1_ligand | Neurons(Nos)_target | CDH1_receptor | 1.098e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Neurons(Nos)_target | CDH1_receptor | 4.071e-04 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Neurons(Nos)_target | CDH1_receptor | 1.441e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 4.309e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Good)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 2.684e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Nos)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 3.458e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 4.071e-04 | 0.01 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 1.285e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Skeletal,muscle(Good)_target | CDH1_receptor | 4.568e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Nos)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 1.528e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Good)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 9.549e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Mesangial,cells(Nos)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 1.230e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Neurons(Nos)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 1.441e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Good)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 4.568e-04 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Skeletal,muscle(Nos)_source | CDH1_ligand | Skeletal,muscle(Nos)_target | CDH1_receptor | 1.622e-03 | 0.0 | CDH | Cell-Cell Contact | KEGG: hsa04514 |
| Adipocytes(Good)_source | SEMA6A_ligand | Mesangial,cells(Good)_target | PLXNA2_receptor | 1.292e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Nos)_source | SEMA6A_ligand | Mesangial,cells(Good)_target | PLXNA2_receptor | 1.403e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Good)_source | SEMA6A_ligand | Mesangial,cells(Good)_target | PLXNA2_receptor | 8.237e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Nos)_source | SEMA6A_ligand | Mesangial,cells(Good)_target | PLXNA2_receptor | 9.865e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA6A_ligand | Mesangial,cells(Good)_target | PLXNA2_receptor | 1.218e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Good)_source | SEMA6A_ligand | Mesangial,cells(Good)_target | PLXNA2_receptor | 3.791e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Nos)_source | SEMA6A_ligand | Mesangial,cells(Good)_target | PLXNA2_receptor | 1.541e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Good)_source | SEMA6A_ligand | Mesangial,cells(Nos)_target | PLXNA2_receptor | 1.802e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Nos)_source | SEMA6A_ligand | Mesangial,cells(Nos)_target | PLXNA2_receptor | 1.959e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Good)_source | SEMA6A_ligand | Mesangial,cells(Nos)_target | PLXNA2_receptor | 1.147e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Nos)_source | SEMA6A_ligand | Mesangial,cells(Nos)_target | PLXNA2_receptor | 1.375e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA6A_ligand | Mesangial,cells(Nos)_target | PLXNA2_receptor | 1.706e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Good)_source | SEMA6A_ligand | Mesangial,cells(Nos)_target | PLXNA2_receptor | 5.286e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Nos)_source | SEMA6A_ligand | Mesangial,cells(Nos)_target | PLXNA2_receptor | 2.147e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Good)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 6.516e-05 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 7.073e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Good)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 4.158e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 4.977e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 6.138e-04 | 0.02 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Good)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 1.913e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Good)_target | PLXNA2_receptor | 7.775e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Good)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 2.509e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Adipocytes(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 2.723e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Good)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 1.601e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Mesangial,cells(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 1.917e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Neurons(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 2.362e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Good)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 7.365e-04 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |
| Skeletal,muscle(Nos)_source | SEMA6A_ligand | Skeletal,muscle(Nos)_target | PLXNA2_receptor | 2.994e-03 | 0.0 | SEMA6 | Cell-Cell Contact | PMID: 27533782 |